Leukemia (CLL)

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Determining When CLL Treatment is Needed

Dr. Nicole Lamanna Columbia University Medical Center

CLL is a chronic disease so there are a lot of factors that go into a doctor’s decision as to when to begin CLL treatment. 

“Knowing the tempo and history of what people’s blood counts are doing is the most important thing,” says Dr. Nicole Lamanna, a leukemia specialist at Columbia University Medical Center. She says there’s no one number that will trigger treatment. This means CLL patients are monitored and their blood count is tracked over time. The blood counts are followed because they act as a marker for how extensively the bone marrow is involved with disease. And if the marrow has significant enough involvement that may lead to CLL treatment.

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Dr. Nicole Lamanna is a hematologist/oncologist at Columbia University Medical Center. Her research interests include lymphoid leukemias, specifically chronic lymphocytic leukemia (CLL). Read More

Treating CLL

There have been major strides when it comes to treating CLL in recent years. Since this is a disease that doesn’t always require treatment immediately, we asked top doctors to explain how they determine when and how to treat the disease.

Treatment: Oral Medications

For patients diagnosed with CLL, the go-to treatment option is usually some form of chemo-immunotherapy. But this is not an option for all patients.


Oral Medicine for Relapsed CLL: Venetoclax


Oral Medicine for CLL: Ibrutinib


Oral Medicine for Relapsed CLL

Dr. Matthew Davids
Dana-Farber Cancer Institute