‘To Love Somebody’ Singer Michael Bolton’s Daughters Recall Noticing Something ‘Wrong’ With His Brain Before Brain Tumor Diagnosis

His daughter Taryn told People, how Bolton had mistakenly bowled out of turn more than once during a bowling night out with his family in November 2023, which she described as “super weird.”

View this post on Instagram

A post shared by Michael Bolton (@michaelbolton)

Taryn, 45, told the celebrity news outlet, ” That was when we were like, ‘Something’s wrong with his brain.’

“Everything that happened was weird for him but not super alarming. When you look back at everything together … We missed so many things.”

Looking back on earlier that day, she said her dad also “fell out of his chair to the left, which is very unusual,” adding, “He’s super athletic, and he doesn’t drink. So he fell, and we were like, ‘What just happened?’”

That same weekend he suffered an abnormally painful headache. By Monday morning he sought medical advice at a nearby hospital where he learned he had a brain tumor and needed to undergo emergency surgery.

Before his hospital visit, and prior to the bowling incident, Bolton also had trouble with his balance and experienced nausea. Despite Bolton’s daughters, including 47-year-old Holly and 49-year-old Isa dismissing his symptoms to stress, Taryn recounted to People thinking, “Is this stress? Is this sleep?”

She continued, “He’d been working nonstop that whole time. Traveling, doing shows, doing all of these things. We were like, he’s getting older, he’s tired, he’s stressed out.

“All of these things we sort of explained in a way, one by one.”

View this post on Instagram

A post shared by People Magazine (@people)

In an effort to spread awareness on the disease he’s battling and further share his story, Bolton took to Instagram this week to say, “The story of my cancer diagnosis was just published by People magazine. Sharing such a profoundly personal chapter of my life hasn’t been easy, but People has long been a champion of human interest stories and there’s no other publication that approaches families with the same compassion, care, and sincerity.

“My hope in sharing this part of my journey is that it might offer comfort to other families facing similar challenges, and perhaps even inspire those navigating their own adversity.”

He also noted, “I also want to thank all of you for the love, support, and patience you’ve shown over this past year.

“I’ve drawn strength from your encouragement, and I continue to draw strength from it every day as I move forward on this journey.”

Michael Bolton’s Brain Tumor Battle

Bolton first went public with his brain tumor diagnosis in an emotional Facebook post last January, revealing that “2023 ended up presenting me with some very unexpected challenges …  just before the holidays, it was discovered that I had a brain tumor, which required immediate surgery.”

He explained, “Thanks to my incredible medical team, the surgery was a success. I am now recuperating at home and surrounded by the tremendous love and support of my family.

“For the next couple of months, I will be devoting my time and energy to my recovery which means I’ll have to take a temporary break from touring.”

It wasn’t until his recent interview with People magazine that it was revealed the type of brain cancer he was diagnosed with was glioblastoma, most aggressive form of brain cancer.

Since his surgery, Bolton underwent both radiation and chemotherapy, which he concluded in the fall of 2024. He now gets routine MRIs every two months to check that the tumor doesn’t come back.

His most recent scan, which he had done in April, was clear.

Understanding Glioblastoma

Glioblastoma (GBM) is the most aggressive and lethal form of primary brain tumor.

A glioma is a tumor originating in the central nervous system (CNS), specifically in the brain or spinal cord. A glioma originates in glial cells. Glial cells are supportive cells in the brain that protect and maintain the neurons. These types of tumors can either be benign (non-cancerous) or malignant (cancerous).

Glioblastomas present doctors with a significant challenge for treatment due to their highly invasive nature, rapid growth, and resistance to most conventional therapies.

WATCH: Understanding Gliomas

Diagnosing gliomas involves a multi-step approach that involves clinical assessment, imaging studies, histopathological examination, and molecular testing.

As patients are diagnosed, they’re observed for typical glioma symptoms. These may include:

• Headaches
• Seizures
• Cognitive or Behavior Changes
• Visual or Speech Changes and Impairments
• Loss of Body Weight and Deconditioning
• Changes in mental function, mood, or personality
• Changes in speech
• Sensory changes in hearing, smell, and sight
• Loss of balance
• Changes in your pulse and breathing rate

Patients then undergo a neurological exam that tests cranial nerve function, motor strength and coordination, sensory function, and cognitive abilities.

Next, patients undergo an MRI, which provides doctors with a visualization of the tumor.

“If you’re suspected of having a tumor on imaging and our neurosurgeons think that tumor can come out, they will take a piece of that tumor out first and confirm in the operating room and with our pathologists that, in fact, what they are looking at is a tumor,” Dr. Alexandra Miller, Director of the Neuro-Oncologist Division at NYU Langone Health, tells SurvivorNet. “And if it is, they resect it at that time. It’s not usually a two-step procedure.”

If surgery cannot be performed due to tumor location or patient-specific factors, a less invasive stereotactic biopsy can be obtained. Once the tissue sample is obtained, it’s examined under a microscope for molecular testing. At this stage, the tumor is given a grade, which determines how aggressive it is.

• Grade I-II gliomas – These are considered low-grade and tend to grow slowly. “The grade one is a very indolent, benign tumor that can be cured with surgery alone,” Dr. Henry Friedman, Deputy Director of the Preston Robert Tisch Brain Tumor Center at Duke, tells SurvivorNet.
• Grade III gliomas – These are considered high-grade and tend to grow more rapidly. They are typically classified as malignant and require more aggressive treatment, which can include surgery, radiation, and chemotherapy.
• Grade IV gliomas – These are the most aggressive gliomas, which are locally aggressive and require treatment intensification. Glioblastomas are the most common grade IV glioma, “which is by far the most well-known and feared tumor in the lay population and, quite frankly, the medical population,” Dr. Friedman explains.

The Standard of Care for Glioblastoma

After you’ve had a full work-up, experts say getting a consultation at a treatment center that sees a lot of patients with brain cancer can be an extremely valuable step. Utah’s renowned Huntsman Cancer Institute in Salt Lake City is one of these excellent centers.

Dr. Randy Jensen, a neurosurgeon at Huntsman, recently told SurvivorNet that the standard of care for glioblastoma is typically to start with surgery.

“The standard of care for glioblastoma is to start off with a maximal safe resection, and that means having your surgeon pull out all the stops of anything they can do to maximize resection [removal],” Dr. Jensen explains.

The treatment of glioblastoma requires a comprehensive approach involving multiple medical specialties. Your care team may include neurosurgeons, medical oncologists, radiation oncologists, neuro-oncologists, and supportive care specialists.

A Utah Brain Cancer Expert’s Quick Guide To The ‘Standard of Care’ Treatment Options For Glioblastoma

The treatment approach for glioblastoma may consist of the following steps.

1. Surgery: The first step in treatment is often surgical removal of the tumor, also known as resection. The goal of surgery is to remove as much of the tumor as possible while preserving neurological function. Complete removal is often difficult due to the tumor’s infiltrative nature, but reducing the tumor size can improve the effectiveness of subsequent treatments. In cases where surgery is not possible due to the tumor’s location, a biopsy may be performed to confirm the diagnosis.
2. Radiation Therapy: Following surgery, most patients undergo radiation therapy to target any remaining cancer cells. Radiation uses high-energy X-rays or protons to damage the DNA of tumor cells, preventing them from growing and dividing. It is typically administered five days a week over a period of six weeks. Radiation therapy is a crucial component in slowing tumor progression and improving survival rates.
3. Chemotherapy: Temozolomide (TMZ) is the standard chemotherapy drug used in glioblastoma treatment. It is taken orally and works by interfering with the tumor cells’ ability to replicate. TMZ is often used in combination with radiation therapy (concurrent chemoradiation) and then continued as maintenance therapy for several months.
4. Tumor Treating Fields (TTFs): TTFs are a newer, non-invasive treatment option that uses alternating electrical fields to disrupt cancer cell division. This therapy, known by the brand name Optune, is discussed in more detail below.

After surgery, the next step is to “present that case in a multidisciplinary tumor board where everybody is in the room and everybody can review the pathology together; everyone can review the images pro-operation and post-operation,” Dr. Jensen explains.

The purpose of the tumor board is to give brain cancer experts with different specialties the opportunity to discuss and decide on the best possible treatment approach.

Side Effects of Glioblastoma Treatment

Each glioblastoma treatment comes with potential side effects. Your medical team will work with you to manage these effects and improve your quality of life.

Surgery side effects can include:

• Swelling in the brain (edema), which may require steroids to reduce inflammation
• Neurological deficits, such as difficulty speaking, memory problems, or muscle weakness, depending on the tumor’s location
• Infection or bleeding at the surgical site

Radiation side effects can include:

• Fatigue, which can persist for weeks after treatment ends
• Hair loss in the treated area
• Skin irritation or redness
• Cognitive effects, such as difficulty concentrating or memory problems

Chemotherapy side effects can include:

• Nausea and vomiting
• Increased risk of infections due to lower white blood cell counts
• Fatigue
• Low blood platelet levels, which can increase the risk of bleeding or bruising

Tumor Treating Fields (TTFs) side effects can include:

• Skin irritation from the transducer arrays
• Mild to moderate headaches
• Scalp sensitivity
• Psychological adjustment to wearing the device for extended periods

When are Tumor Treating Fields Used?

Tumor Treating Fields (TTFs) represent an exciting advancement in glioblastoma treatment. This therapy is designed to slow tumor growth without affecting healthy brain tissue.

TTFs use low-intensity, alternating electric fields to disrupt cancer cell division. This is achieved through a wearable device that delivers continuous therapy on the scalp. These fields interfere with the tumor cells’ ability to multiply, ultimately slowing or stopping tumor progression.

Two major clinical trials, EF-11 and EF-14, demonstrated that TTFs provide a survival benefit for glioblastoma patients:

• EF-11 Trial: This trial focused on recurrent glioblastoma and found that patients receiving TTF therapy had comparable survival rates to those receiving chemotherapy, but with fewer side effects
• EF-14 Trial: This trial demonstrated that newly diagnosed glioblastoma patients who used TTFs alongside standard chemotherapy had significantly improved survival compared to those who received chemotherapy alone

TTFs may be recommended in the following scenarios:

• Newly Diagnosed Glioblastoma: After surgery, radiation, and chemotherapy, TTFs can be integrated into the treatment plan to enhance survival rates. The device is typically used continuously for at least 18 hours per day to maximize its effectiveness.
• Recurrent Glioblastoma: For patients whose tumors have returned, TTFs may be an option to extend survival and manage disease progression.

Your healthcare team will assess your overall health, tumor characteristics, and previous treatments to determine if TTFs are suitable for you. Factors such as your ability to wear the device consistently and your comfort with its use will also be considered.

The Future of Glioblastoma Treatment

Research into new glioblastoma treatments is ongoing.

Some promising areas of focus include:

• Immunotherapy: Exploring ways to activate the body’s immune system to fight the tumor
• Targeted Therapies: Investigating drugs that specifically attack glioblastoma cells with fewer side effects

Clinical trials also offer access to experimental therapies that may improve outcomes. Patients interested in participating in clinical trials should discuss options with their oncologists. Check out SurvivorNet’s simple Clinical Trial Finder here.

Contributing: SurvivorNet Staff

Learn more about SurvivorNet's rigorous medical review process.

---