In about ten percent of CLL patients, their disease transforms into a more aggressive lymphoma called Richter’s Transformation–and it is much more difficult to treat. Patients who suffer from Richter’s Transformation may experience symptoms like fever, night sweats and weight loss, that indicate a change in their disease. Doctors typically treat these patients with large cell lymphoma therapy, “but it doesn’t work so well,” says Dr Nicole Lamanna, a leukemia specialist at Columbia University Medical School. In certain instances, a stem cell transplant may be required.
RS: Median survival is 10 months.
There have been major breakthroughs when it comes to treating CLL. This series outlines some of the newer treatments for later-stage disease.
Clinical Trials for CLL Treatments
Do I Need A Stem Cell Transplant For CLL?
New Treatment for Relapsed CLL Patients
New Treatment Options for CLL
CAR-T therapy has been approved for other types of blood cancers, and it is showing promise for CLL in clinical trials.
Clinical Trials Using CAR-T Cells Are Extremely Promising
What is CAR-T Therapy?