Leukemia (CLL)

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What is Richter’s Transformation?

Dr. Nicole Lamanna Columbia University Medical Center

In about ten percent of CLL patients, their disease transforms into a more aggressive lymphoma called Richter’s Transformation–and it is much more difficult to treat. Patients who suffer from Richter’s Transformation may experience symptoms like fever, night sweats and weight loss, that indicate a change in their disease. Doctors typically treat these patients with large cell lymphoma therapy, “but it doesn’t work so well,” says Dr Nicole Lamanna, a leukemia specialist at Columbia University Medical School. In certain instances, a stem cell transplant may be required.

RS: Median survival is 10 months.



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Dr. Nicole Lamanna is a hematologist/oncologist at Columbia University Medical Center. Her research interests include lymphoid leukemias, specifically chronic lymphocytic leukemia (CLL). Read More

Later Stage Treatment: CAR-T Therapy

CAR-T therapy has been approved for other types of blood cancers, and it is showing promise for CLL in clinical trials.


Clinical Trials Using CAR-T Cells Are Extremely Promising

Dr. Nina Shah
UCSF Medical Center

What is CAR-T Therapy?

Dr. Matthew Davids
Dana-Farber Cancer Institute