Acute Myeloid Leukemia Clinical Trial
Brentuximab Vedotin in Patients With CD30-positive Nonlymphomatous Malignancies
Summary
This is an open-label, multicenter, phase 2 clinical trial to evaluate the antitumor activity of brentuximab vedotin as a single agent in patients with CD30-positive nonlymphomatous malignancies.
Eligibility Criteria
Inclusion Criteria:
Histologically-confirmed by central review CD30-positive nonlymphomatous malignancy
Have failed, refused, or have been deemed ineligible for standard therapy
Measurable disease
Eastern Cooperative Oncology Group (ECOG) Performance Status score of 0 or 1 or a Karnofsky or Lansky Performance Status score greater than or equal to 70
Exclusion Criteria:
Primary diagnosis of lymphoma or central nervous system (CNS) malignancy
History of another primary invasive malignancy that has not been definitively treated or in remission for at least 3 years
Evidence of active cerebral/meningeal disease
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There are 28 Locations for this study
Birmingham Alabama, 35294, United States
Duarte California, 91010, United States
Oxnard California, 93030, United States
Aurora Colorado, 80012, United States
Jacksonville Florida, 32224, United States
Ocala Florida, 34471, United States
Indianapolis Indiana, 46202, United States
Boston Massachusetts, 02215, United States
Minneapolis Minnesota, 55404, United States
Albany New York, 12206, United States
Cleveland Ohio, 44106, United States
Eugene Oregon, 97401, United States
Tulatin Oregon, 97062, United States
Greenville South Carolina, 29605, United States
Bedford Texas, 76022, United States
Dallas Texas, 75230, United States
Dallas Texas, 75231, United States
Denton Texas, 76210, United States
Fort Worth Texas, 76104, United States
Houston Texas, 77030, United States
Houston Texas, 77030, United States
Round Rock Texas, 78731, United States
San Antonio Texas, 78229, United States
Waco Texas, 76712, United States
Blacksburg Virginia, 24060, United States
Fairfax Virginia, 22031, United States
Edmonds Washington, 98026, United States
Spokane Valley Washington, 99216, United States
Yakima Washington, 98902, United States
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