Expanded Access to Provide GL-ONC1 for the Treatment of Advanced Cancers With No Standard of Care

Inclusion Criteria:

Diagnosis of advanced cancers with no standard of care option for treatment.
Willing and able to provide written, signed informed consent.
Use of adequate contraception.
Negative pregnancy test.

Exclusion Criteria:

Have not recovered from severe adverse events from prior therapy.
Major surgery occurred within 28 days prior to treatment.
Known immune system disorders such as HIV, or active hepatitis B or C infection.
Clinically significant cardiac disease (New York Heart Association Class III or IV).
Have received prior therapy with an oncolytic virus of any type.
Be receiving antiviral agent active against vaccinia virus (e.g., cidofovir, vaccinia immunoglobulin, imatinib, ST-246).
Have known allergy to ovalbumin or other egg products.
Have clinically significant dermatological disorders (e.g., eczema, psoriasis, or any unhealed skin wounds or ulcers) as assessed by the treating physician.