Acute Myeloid Leukemia Clinical Trial
Hematopoietic Stem Cell Transplant for Fanconi Anemia
Summary
The trial proposed is a single arm phase II treatment protocol designed to examine engraftment, toxicity, graft-versus-host disease, and ultimate disease-free survival following a novel cytoreductive regimen including busulfan, cyclophosphamide and fludarabine and anti-thymocyte globulin (ATG- a non-chemotherapy drug whose role is to kill your immune system) for the treatment of patients with Fanconi anemia who have severe aplastic anemia (SAA), or myelodysplastic syndrome (MDS) or acute myelogenous leukemia (AML), lacking HLA-genotypically identical donors using stem cell transplants derived from (1) HLA-compatible unrelated donors or (2) HLA haplotype-mismatched related donors.
Full Description
We are currently recruiting patients.
Eligibility Criteria
Inclusion Criteria:
Fanconi Anemia (confirmed by mitomycin C or DEB chromosomal breakage testing and one of the following hematological diagnoses: Severe Aplastic Anemia, Myelodysplastic Syndrome, Acute Myelogenous Leukemia
Karnofsky or Lansy performance scale > or = to 70%.
Must have adequate cardiac, hepatic, renal and pulmonary function.
Must have 7/8 or 8/8 available unrelated donor.
Exclusion Criteria:
Pregnant or breastfeeding.
Active CNS leukemic involvement
Active uncontrolled viral, bacterial or fungal infection
Positive for HIV.
Check Your Eligibility
Let’s see if you might be eligible for this study.
What is your age and gender ?
There is 1 Location for this study
Milwaukee Wisconsin, 53226, United States
How clear is this clinincal trial information?
Please confirm you are a US based health care provider:
Yes, I am a health care Provider No, I am not a health care providerSign Up Now.
Take Control of Your Disease Journey.
Sign up now for expert patient guides, personalized treatment options, and cutting-edge insights that can help you push for the best care plan.