Acute Myeloid Leukemia Clinical Trial

Clinical Trial Finder Acute Myeloid Leukemia Trials

Safety Study of Human Myeloid Progenitor Cells (CLT-008) After Chemotherapy for Leukemia

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Summary

Ex vivo expanded human myeloid progenitor cells (hMPCs; CLT-008) have the potential to accelerate neutrophil recovery and decrease the risk of febrile neutropenia and infection in patients receiving chemotherapy for acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), chronic myeloid leukemia (CML), or high-risk myelodysplasia (MDS). In this study, the safety, tolerability and activity of CLT-008 administered after "standard of care" cytarabine-based consolidation or induction/re-induction chemotherapy will be determined by monitoring for adverse reactions, infusion reactions, graft-versus host disease (GVHD), neutrophil and platelet recovery, hMPC persistence, infections and complications.

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Eligibility Criteria

Key Inclusion Criteria:

Hematological malignancy, including:

AML, ALL or MDS
Planned treatment with cytarabine-based chemotherapy regimen
Adequate hepatic, renal, hematologic, cardiac and respiratory function

Key Exclusion Criteria:

Prior allograft or history of active GVHD within 3 years
Pregnant or nursing

Study is for people with:

Acute Myeloid Leukemia

Phase:

Phase 1

Estimated Enrollment:

45

Study ID:

NCT01297543

Recruitment Status:

Completed

Sponsor:

Cellerant Therapeutics

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There are 10 Locations for this study

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Moores UCSD Cancer Center
La Jolla California, 92037, United States
University of California San Francisco Medical Center
San Francisco California, 94143, United States
Stanford Hospital and Clinics
Stanford California, 94305, United States
Loyola University Medical Center, Cardinal Bernardin Cancer Center
Maywood Illinois, 60153, United States
Indiana Blood and Marrow Transplantation, LLC
Beech Grove Indiana, 46107, United States
University of Massachusetts Memorial Medical Center
Worcester Massachusetts, 01655, United States
University of Minnesota
Minneapolis Minnesota, 55455, United States
Cleveland Clinic
Cleveland Ohio, 44195, United States
The Western Pennsylvania Hospital
Pittsburgh Pennsylvania, 15224, United States
The University of Texas MD Anderson Cancer Center
Houston Texas, 77030, United States
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How clear is this clinincal trial information?

Study is for people with:

Acute Myeloid Leukemia

Phase:

Phase 1

Estimated Enrollment:

45

Study ID:

NCT01297543

Recruitment Status:

Completed

Sponsor:


Cellerant Therapeutics

How clear is this clinincal trial information?

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