Neutrophil-to-Lymphocyte Ratio in Bladder Cancer: A Secondary Biomarker Analysis of SWOG 8710

Inclusion Criteria:

SWOG 8710 original trial inclusion criteria included:

Node-negative, muscle-invasive transitional cell carcinoma of the bladder, T2-T4aN0M0 per the AJCC 4th edition staging manual.
SWOG performance status of 0 or 1
Adequate organ function by lab criteria (WBC > 4,000 cells/mm3, platelets >150,000 cells/mm3, creatinine <1.5 md/dL (men) or <1.3 md/dL (women), baseline liver tests < 2 times normal limits)

Inclusion criteria for this secondary analysis are:

Eligible for original SWOG 8710 trial
Had complete blood count with differential prior to first treatment (radical cystectomy or NAC).

Exclusion Criteria:

SWOG 8710 original trial exclusion criteria included:

No age restrictions
Previous or concomitant malignancy other than bladder cancer or basal cell skin cancer
Prior pelvic radiation
Metastatic or incurable disease
Laboratory values exceeding those detailed in 3.1.c

Exclusion criteria for this secondary analysis are:

Ineligibility for the original SWOG 8710 study
Lack of complete blood count with differential prior to first treatment (cystectomy or NAC).