Pre-Habilitation With Mindfulness and Exercise for Patients Undergoing Radical Cystectomy (PRIMER Trial)

Inclusion Criteria:

Provision of signed and dated informed consent form
Stated willingness to comply with all study procedures and availability for the duration of the study
Male or female, aged ≥18 years of age
Good surgical candidate determined by treating surgeon
Histologically documented muscle invasive urothelial carcinoma of the bladder, high-risk non-muscle invasive bladder cancer, non-muscle invasive bladder cancer refractory to BCG, cisplatin ineligible muscle invasive bladder cancer receiving upfront cystectomy, urothelial carcinoma of the bladder with variant histology
Adequate Organ Function per protocol definition
ECOG performance status ≤2
Received medical clearance to complete cardiopulmonary exercise testing
Willing to use the personal or study provided devices for monitoring and performing the exercise routines.
Fluent in English or Spanish for the EORTC QLQ questionnaire
No known contraindications to high intensity exercise

Exclusion Criteria:

Contraindications to participating in aerobic exercise
Currently participating in an aerobic exercise program
New onset chest pain nor dyspnea with exertion
Histologically documented micropapillary or sarcomatoid bladder cancer
Distant metastatic carcinoma