Bladder Cancer Clinical Trial
Rucaparib in Patients With Locally Advanced or Metastatic Urothelial Carcinoma
Summary
The purpose of the ATLAS study is to determine how patients with locally advanced unresectable or metastatic urothelial carcinoma respond to treatment with rucaparib.
View Eligibility Criteria
Eligibility Criteria
Inclusion Criteria:
Have histologically or cytologically confirmed locally advanced unresectable or metastatic transitional cell carcinoma of the urothelium (renal pelvis, ureter, urinary bladder or urethra)
Received 1 or 2 prior treatment regimens for advanced or metastatic disease
Confirmed radiologic disease progression during or following recent treatment
Mandatory biopsy is required during screening
Measurable disease per RECIST v1.1
Adequate organ function
ECOG 0 or 1
Exclusion Criteria:
Prior treatment with a PARP inhibitor
Symptomatic and/or untreated CNS metastases
Duodenal stent and/or any gastrointestinal disorder that may interfere with absorption of rucaparib
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There are 64 Locations for this study
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Pinnacle Oncology, Honor Health
Scottsdale Arizona, 85258, United States
Scottsdale Arizona, 85258, United States
University of California San Diego (UCSD), Moores Cancer Center
La Jolla California, 92093, United States
La Jolla California, 92093, United States
University of California, Los Angeles (UCLA)
Los Angeles California, 90095, United States
Los Angeles California, 90095, United States
Universityof California, Irvine
Orange California, 92868, United States
Orange California, 92868, United States
Saint John's Health Center - John Wayne Cancer Institute (JWCI)
Santa Monica California, 90404, United States
Santa Monica California, 90404, United States
Stanford University School of Medicine
Stanford California, 94304, United States
Stanford California, 94304, United States
Hartford Health Care Cancer Institute
Hartford Connecticut, 06102, United States
Hartford Connecticut, 06102, United States
Eastern Connecticut Hematology & Oncology Associates (ECHO)
Norwich Connecticut, 06360, United States
Norwich Connecticut, 06360, United States
Medstar Georgetown University Medical Center
Washington District of Columbia, 20007, United States
Washington District of Columbia, 20007, United States
Miami Cancer Institute, Baptist Health South Florida
Miami Florida, 33176, United States
Miami Florida, 33176, United States
Northwestern University, Chicago
Chicago Illinois, 60611, United States
Chicago Illinois, 60611, United States
Indiana University - Melvin and Bren Simon Cancer Center (IUSCC)
Indianapolis Indiana, 46202, United States
Indianapolis Indiana, 46202, United States
The University of Iowa and Holden Comprehensive Cancer Center
Iowa City Iowa, 52242, United States
Iowa City Iowa, 52242, United States
Norton Cancer Center
Louisville Kentucky, 40207, United States
Louisville Kentucky, 40207, United States
Ochsner Cancer Institute
New Orleans Louisiana, 70121, United States
New Orleans Louisiana, 70121, United States
University of Maryland, Marlene and Stewart Greenebaum Cancer Center
Baltimore Maryland, 21201, United States
Baltimore Maryland, 21201, United States
University of Michigan
Ann Arbor Michigan, 48109, United States
Ann Arbor Michigan, 48109, United States
Minnesota Oncology Hematology P.A. (USO - US Oncology)
Minneapolis Minnesota, 55404, United States
Minneapolis Minnesota, 55404, United States
Comprehensive Cancer Centers of Nevada (CCCN)
Las Vegas Nevada, 89169, United States
Las Vegas Nevada, 89169, United States
John Theurer Cancer Center at Hackensack University Medical Center
Hackensack New Jersey, 07601, United States
Hackensack New Jersey, 07601, United States
University of New Mexico UNM Cancer Research and Treatment Center
Albuquerque New Mexico, 87102, United States
Albuquerque New Mexico, 87102, United States
New York Oncology Hematology, P.C. (USO - US Oncology)
Albany New York, 12208, United States
Albany New York, 12208, United States
Roswell Park Cancer Institute
Buffalo New York, 14263, United States
Buffalo New York, 14263, United States
New York - Presbyterian Hospital-Weill Cornell Medical Center
New York New York, 10021, United States
New York New York, 10021, United States
Memorial Sloan Kettering Cancer Center
New York New York, 10065, United States
New York New York, 10065, United States
Duke University, Duke Cancer Institute
Durham North Carolina, 27710, United States
Durham North Carolina, 27710, United States
Stephenson Cancer Center
Oklahoma City Oklahoma, 73104, United States
Oklahoma City Oklahoma, 73104, United States
Northwest Cancer Specialists P.C. (USO - US Oncology)
Portland Oregon, 97062, United States
Portland Oregon, 97062, United States
Providence Portland Medical Center
Portland Oregon, 97213, United States
Portland Oregon, 97213, United States
Oregon Health and Science University
Portland Oregon, 97239, United States
Portland Oregon, 97239, United States
Lehigh Valley Health Network
Allentown Pennsylvania, 18103, United States
Allentown Pennsylvania, 18103, United States
Penn State Hershey Medical Center
Hershey Pennsylvania, 17033, United States
Hershey Pennsylvania, 17033, United States
Atlantic Urology Clinics
Myrtle Beach South Carolina, 29572, United States
Myrtle Beach South Carolina, 29572, United States
University Oncology & Hematology
Chattanooga Tennessee, 37403, United States
Chattanooga Tennessee, 37403, United States
Urology Associates
Nashville Tennessee, 37209, United States
Nashville Tennessee, 37209, United States
Texas Oncology PA (USO - US Oncology)
Dallas Texas, 76201, United States
Dallas Texas, 76201, United States
University of Texas, UT Health Science Center
Houston Texas, 77030, United States
Houston Texas, 77030, United States
University of Utah, Huntsman Cancer Institute
Salt Lake City Utah, 84112, United States
Salt Lake City Utah, 84112, United States
University of Virginia, Emily Couric Clinical Center
Charlottesville Virginia, 22908, United States
Charlottesville Virginia, 22908, United States
University of Washington / Seattle Cancer Care Alliance
Seattle Washington, 98109, United States
Seattle Washington, 98109, United States
Froedtert & Medical College of Wisconsin
Milwaukee Wisconsin, 53226, United States
Milwaukee Wisconsin, 53226, United States
Centre de Lutte Contre le Cancer (CLCC) - Universite de Lyon - Centre Leon-Berard
Lyon , 69008, France
Lyon , 69008, France
Hopital Saint-Louis
Paris , 75010, France
Paris , 75010, France
Centre de Lutte Contre le Cancer - Institut de Cancerologie de l'Ouest - Rene Gauducheau
Saint-Herblain , 44805, France
Saint-Herblain , 44805, France
Institut Universitaire du Cancer de Toulouse - Oncopole
Toulouse , 31059, France
Toulouse , 31059, France
Institut Gustave Roussy
Villejuif , 94805, France
Villejuif , 94805, France
Urologische und Kinderurologische Universitätsklinik im Malteser
Erlangen , 91054, Germany
Erlangen , 91054, Germany
Universitatsklinikum Munster / Urologie und Kinderurologie
Münster , 26133, Germany
Münster , 26133, Germany
Studienpraxis Urologie
Nurtingen , 72622, Germany
Nurtingen , 72622, Germany
Fondazionerca sul Cancro ONLUS - Istituto di Candiolo IRCCS
Candiolo , 10060, Italy
Candiolo , 10060, Italy
IRCCS Ospedale San Raffaele - Medical Oncology Dept
Milano , 20132, Italy
Milano , 20132, Italy
Fondazione IRCCS Istituto Nazionale Tumori
Milano , 20133, Italy
Milano , 20133, Italy
Azienda Ospedaliera Universitaria Federico II Oncologia Medica
Naples , 80131, Italy
Naples , 80131, Italy
Universidad de Navarra - Clinica Universitaria de Navarra
Pamplona Navarre, 31008, Spain
Pamplona Navarre, 31008, Spain
Hospital del Mar
Barcelona , 08003, Spain
Barcelona , 08003, Spain
Hospital Santa Creu i Sant Pau
Barcelona , 08025, Spain
Barcelona , 08025, Spain
Hospital Universitari Vall d'Hebron de Barcelona
Barcelona , 08035, Spain
Barcelona , 08035, Spain
Hospital General Universitario Gregorio Maranon
Madrid , 28007, Spain
Madrid , 28007, Spain
Clinica Universitaria de Navarra Madrid
Madrid , 28027, Spain
Madrid , 28027, Spain
MD Anderson Cancer Center
Madrid , 28033, Spain
Madrid , 28033, Spain
Hospital Universitario 12 de Octubre
Madrid , 28041, Spain
Madrid , 28041, Spain
Hospital ClÃnico Universitario de Santiago de Compostela
Santiago De Compostela , 15706, Spain
Santiago De Compostela , 15706, Spain
Sarah Cannon Research Institute - United Kingdom - London Office
London , CH63 , United Kingdom
London , CH63 , United Kingdom
Guy's & St. Thomas' Hospital (London Oncology Clinic)
London , W1G 6, United Kingdom
London , W1G 6, United Kingdom
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