Breast Cancer Clinical Trial
A Study Evaluating PF-03084014 In Patients With Advanced Breast Cancer With Or Without Notch Alterations
Summary
This study is designed to evaluate the preliminary anti-tumor activity and tolerability of PF-03084014 when administered as a single agent in the treatment of patients with advanced triple receptor-negative breast cancer (mTNBC) harboring genomic alterations in Notch receptors (NA+), and in a smaller subset of mTNBC patients whose tumor tests negative for genomic alterations in Notch receptors (NA-)
Eligibility Criteria
Inclusion Criteria:
Histological or cytological diagnosis of triple negative breast cancer (TNBC) with evidence of a) metastatic or b) locally recurrent advanced disease that is not amenable to resection or radiotherapy with curative intent.
Availability of an original diagnostic tumor tissue or the most recent metastatic tumor biopsies (archival biopsy or de novo biopsy) and a peripheral blood sample for Notch receptors genomic profiling
Exclusion Criteria:
Known brain metastases.
Prior treatment with gamma secretase inhibitor or other Notch signaling inhibitor.
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There are 33 Locations for this study
Stanford California, 94305, United States
Stanford California, 94305, United States
Stanford California, 94305, United States
Chicago Illinois, 60637, United States
Chicago Illinois, 60637, United States
New Lenox Illinois, 60451, United States
Zion Illinois, 60099, United States
Boston Massachusetts, 02115, United States
Boston Massachusetts, 02215, United States
Basking Ridge New Jersey, 07920, United States
Paramus New Jersey, 07652, United States
Paramus New Jersey, 07652, United States
Westwood New Jersey, 07675, United States
Commack New York, 11725, United States
Harrison New York, 10604, United States
New York New York, 10065, United States
Rockville Centre New York, 11570, United States
Sleepy Hollow New York, 10591, United States
Debrecen , 4032, Hungary
Lecce , 73100, Italy
Milan , 20141, Italy
Krakow , 31108, Poland
Krakow , 31216, Poland
Poznan , 60-56, Poland
A Coruna , 15006, Spain
Barcelona , 08035, Spain
Barcelona , 08036, Spain
Barcelona , 08041, Spain
Barcelona , 08908, Spain
Madrid , 28007, Spain
Madrid , 28041, Spain
Sevilla , 41013, Spain
Valencia , 46010, Spain
Glasgow Scotland, G12 0, United Kingdom
Glasgow Scotland, G52 3, United Kingdom
London , SW3 6, United Kingdom
Surrey , SM2 5, United Kingdom
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