Breast Cancer Clinical Trial
Assessment of Candidate Protein Expression in Breast Cancer Specimens
Summary
RATIONALE: Studying the genes expressed in samples of tumor tissue from patients with cancer may help doctors identify biomarkers related to cancer.
PURPOSE: This research study is looking at tumor tissue samples from patients who have undergone surgery for breast cancer.
Full Description
OBJECTIVES:
To determine if candidate genes display differential expression between normal and cancer breast tissues.
OUTLINE: Previously collected breast cancer tissue samples (paraffin embedded blocks) and normal adjacent tissue are used for immunohistochemistry studies of expression of candidate genes.
Eligibility Criteria
Inclusion Criteria:
DISEASE CHARACTERISTICS:
Diagnosis of breast cancer
Tissue samples available
Samples are selected based on presence or absence of tumor receptors, (i.e.; estrogen, progesterone, and HER2 receptors) and grouped into following 4 categories:
Estrogen receptor (ER)-positive/progesterone receptor (PR)-positive/HER2-negative
ER-positive/PR-positive/ HER2-positive by FISH
ER-negative/PR-negative/HER2-positive
ER-negative/PR-negative/HER2-negative(triple negative or basal-type cancers)
PATIENT CHARACTERISTICS:
Menopausal status not specified
PRIOR CONCURRENT THERAPY:
Not specified
Exclusion Criteria:
There are no exclusion criteria in this protocol
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There is 1 Location for this study
Cleveland Ohio, 44106, United States
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