Breast Cancer Clinical Trial

Assessment of Candidate Protein Expression in Breast Cancer Specimens

Summary

RATIONALE: Studying the genes expressed in samples of tumor tissue from patients with cancer may help doctors identify biomarkers related to cancer.

PURPOSE: This research study is looking at tumor tissue samples from patients who have undergone surgery for breast cancer.

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Full Description

OBJECTIVES:

To determine if candidate genes display differential expression between normal and cancer breast tissues.

OUTLINE: Previously collected breast cancer tissue samples (paraffin embedded blocks) and normal adjacent tissue are used for immunohistochemistry studies of expression of candidate genes.

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Eligibility Criteria

Inclusion Criteria:

DISEASE CHARACTERISTICS:

Diagnosis of breast cancer
Tissue samples available

Samples are selected based on presence or absence of tumor receptors, (i.e.; estrogen, progesterone, and HER2 receptors) and grouped into following 4 categories:

Estrogen receptor (ER)-positive/progesterone receptor (PR)-positive/HER2-negative
ER-positive/PR-positive/ HER2-positive by FISH
ER-negative/PR-negative/HER2-positive
ER-negative/PR-negative/HER2-negative(triple negative or basal-type cancers)

PATIENT CHARACTERISTICS:

Menopausal status not specified

PRIOR CONCURRENT THERAPY:

Not specified

Exclusion Criteria:

There are no exclusion criteria in this protocol

Study is for people with:

Breast Cancer

Estimated Enrollment:

460

Study ID:

NCT00918892

Recruitment Status:

Completed

Sponsor:

Case Comprehensive Cancer Center

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There is 1 Location for this study

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University Hospitals Cleveland Medical Center, Case Comprehensive Cancer Center
Cleveland Ohio, 44106, United States

How clear is this clinincal trial information?

Study is for people with:

Breast Cancer

Estimated Enrollment:

460

Study ID:

NCT00918892

Recruitment Status:

Completed

Sponsor:


Case Comprehensive Cancer Center

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