Breast Cancer Clinical Trial
Blood Glycan Biomarkers in Women With Stage IV Breast Cancer
Summary
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur and identify biomarkers related to cancer.
PURPOSE: This research study is looking at blood glycan biomarkers in women with stage IV breast cancer.
Full Description
OBJECTIVES:
To profile serum glycan biomarkers in women with metastatic stage IV breast cancer, healthy controls, and patients with noncancer medical illness.
To determine whether serial serum glycan biomarkers correlate with response of metastatic disease to treatment.
OUTLINE: This is a multicenter study.
Blood is collected from patients with metastatic breast cancer, patients with noncancerous illness, and healthy volunteers. Samples are analyzed for serum glycan biomarkers by matrix-assisted laser desorption/ionization (MALDI) and Fourier transform ion-cyclotron resonance mass spectrometry (FT ICR MS) methods.
Blood samples are collected every 3 months for up to 18 months from patients with metastatic breast cancer. Patients without cancer have a single sample collected.
Eligibility Criteria
DISEASE CHARACTERISTICS:
Patient or participant at the Women's Health Clinic, the Internal Medicine Clinic, or at the UC Davis Cancer Center, meeting 1 of the following criteria:
Diagnosis of stage IV metastatic breast cancer, receiving active treatment with chemotherapy, endocrine therapy, or targeted therapy
Patients/participants without cancer
Healthy control being seen for annual exams, meeting the following criteria:
No chronic disease
Not on regular prescribed medications
Patient without cancer being seen in the Internal Medicine Clinic
Hormone receptor status not specified
PATIENT CHARACTERISTICS:
Menopausal status not specified
Not pregnant or breast feeding
No other active cancer
PRIOR CONCURRENT THERAPY:
See Disease Characteristics
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There is 1 Location for this study
Sacramento California, 95817, United States
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