Breast Cancer Clinical Trial

Blood Glycan Biomarkers in Women With Stage IV Breast Cancer

Summary

RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur and identify biomarkers related to cancer.

PURPOSE: This research study is looking at blood glycan biomarkers in women with stage IV breast cancer.

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Full Description

OBJECTIVES:

To profile serum glycan biomarkers in women with metastatic stage IV breast cancer, healthy controls, and patients with noncancer medical illness.
To determine whether serial serum glycan biomarkers correlate with response of metastatic disease to treatment.

OUTLINE: This is a multicenter study.

Blood is collected from patients with metastatic breast cancer, patients with noncancerous illness, and healthy volunteers. Samples are analyzed for serum glycan biomarkers by matrix-assisted laser desorption/ionization (MALDI) and Fourier transform ion-cyclotron resonance mass spectrometry (FT ICR MS) methods.

Blood samples are collected every 3 months for up to 18 months from patients with metastatic breast cancer. Patients without cancer have a single sample collected.

View Eligibility Criteria

Eligibility Criteria

DISEASE CHARACTERISTICS:

Patient or participant at the Women's Health Clinic, the Internal Medicine Clinic, or at the UC Davis Cancer Center, meeting 1 of the following criteria:

Diagnosis of stage IV metastatic breast cancer, receiving active treatment with chemotherapy, endocrine therapy, or targeted therapy

Patients/participants without cancer

Healthy control being seen for annual exams, meeting the following criteria:

No chronic disease
Not on regular prescribed medications
Patient without cancer being seen in the Internal Medicine Clinic
Hormone receptor status not specified

PATIENT CHARACTERISTICS:

Menopausal status not specified
Not pregnant or breast feeding
No other active cancer

PRIOR CONCURRENT THERAPY:

See Disease Characteristics

Study is for people with:

Breast Cancer

Estimated Enrollment:

163

Study ID:

NCT00897962

Recruitment Status:

Completed

Sponsor:

University of California, Davis

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There is 1 Location for this study

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University of California Davis Cancer Center
Sacramento California, 95817, United States

How clear is this clinincal trial information?

Study is for people with:

Breast Cancer

Estimated Enrollment:

163

Study ID:

NCT00897962

Recruitment Status:

Completed

Sponsor:


University of California, Davis

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