Breast Cancer Clinical Trial

Breast-Conserving Surgery and Radiation Therapy in Patients With Multiple Ipsilateral Breast Cancer

Summary

RATIONALE: Breast-conserving surgery is a less invasive type of surgery for breast cancer and may have fewer side effects and improve recovery. Radiation therapy uses high-energy x rays to kill tumor cells. Giving radiation therapy after surgery may kill any tumor cells that remain after surgery.

PURPOSE: This phase II trial studies how well breast-conserving surgery and radiation therapy work in treating patients with multiple ipsilateral breast cancer

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Full Description

OBJECTIVES:

Primary

To assess the local recurrence (LR) rate with breast-conservation in patients with multiple ipsilateral primary breast cancer (MIBC).

Secondary

To examine the conversion rate to mastectomy secondary to persistent positive margins; poor cosmesis within the first year of attempting breast-conservation surgery (BCS) or inability to satisfy the radiation dose constraints on the boost to the lumpectomy bed of each site of disease.
To assess whether patients who did not undergo re-excision for close margins (< 2 mm) have a higher local recurrence (LR) rate than patients for whom negative margins were achieved.
To assess patient's perception of cosmesis and incidence of breast lymphedema.
To assess incidence of breast lymphedema
To examine the type and severity of adverse effects of breast conserving surgery and radiation for women with multiple ipsilateral primary breast cancer (MIBC).
To examine the radiation-related side effects of whole-breast radiation with a boost to 1 large or > 1 lumpectomy site.

OUTLINE: This is a multicenter study.

Patients undergo breast-conserving surgery (BCS) with all lesions resected to negative margins using 1 lumpectomy or 2-3 separate lumpectomy incisions at the discretion of the surgeon. Patients receive adjuvant chemotherapy and/or endocrine therapy at the discretion of the treating medical oncologist based on tumor characteristics.

View Eligibility Criteria

Eligibility Criteria

Registration Inclusion Criteria:

Age ≥ 40 years per National Comprehensive Cancer Network (NCCN) recommendations for breast conservation.
Life Expectancy of at least 5 years, excluding diagnosis of breast cancer (Comorbid conditions should be taken into consideration, but breast cancer diagnosis is not a consideration)

Female Gender - Men are excluded from this study. Male breast cancer is a rare event.

Men are rarely candidates for breast conservation surgery due to small breast size. Men are less likely to be candidates for breast conservation surgery if found to have MIBC.

Men are rarely candidates for breast conservation surgery due to small breast size. Men are less likely to be candidates for breast conservation surgery if found to have MIBC.

Foci of Breast Cancer

4.1 Upon clinical exam and pre-operative imaging by mammogram +/- MRI, two or three foci of biopsy proven breast cancer separated by > 2 cm of normal breast tissue.

4.2 Foci must include at least one focus of invasive breast carcinoma with another focus of either invasive breast carcinoma or ductal carcinoma in situ (DCIS).

No more than 2 quadrants with biopsy proven breast cancer.

4.3 Note: The shortest distance between lesions must be reported on mammogram +/- MRI and eligibility criteria must be met on both, if both are obtained.

4.4 Note: Patient is eligible for study if lesion is not visualized on all imaging modalities (i.e., any of the lesion(s) is/are visualized on MRI but not on mammogram OR visualized on mammogram but not on MRI).

4.5 Ultrasound cannot be used to determine patient eligibility; eligibility to be determined by bilateral mammogram +/- MRI only.

4.6 Fine needle aspirate of the second or third lesion to document malignancy is allowed if the first focus is shown to be invasive by core needle biopsy.

4.7 Patient may remain on study if, upon pathological assessment, two or three lesions identified on pre-operative imaging represent one contiguous lesion.

Patients may be registered AFTER surgery and PRIOR TO radiation therapy if either of the criteria is met:

5.1 An area of atypia > 2cm from the index lesion excised at the time of cancer operation is upgraded to DCIS or invasive carcinoma thereby identifying MIBC. OR

5.2 Patient underwent resection of two or three foci of malignancy by breast conservation surgery with a minimum of one invasive focus of breast cancer and a minimum of 2 cm of normal breast tissue between the lesions on final pathology.

Mammogram Imaging - Bilateral mammogram ≤ 90 days prior to date of surgery.

6.1 Note: For patients undergoing more than 1 breast operation, this is the date of the first breast surgery for breast cancer treatment.

Staging of Cancer - cN0 or cN1 disease
ECOG Performance Status (PS) - 0, 1, or 2.
Ability to Complete Questionnaires - Ability to complete questionnaire(s) by themselves or with assistance
Ability to Provide Written Informed Consent
Willing to Return to Enrolling Institution - Willing to return to enrolling institution for follow-up during the Active Monitoring Phase (the active treatment and observation portions) of the study. Patients are encouraged to return to the enrolling institution; however, patients may receive radiation therapy at a different institution other than the enrolling institution.

Registration Exclusion Criteria:

Pregnancy, Nursing and Requirement for Contraception - Pregnant women, nursing women and women of childbearing potential who are unwilling to employ adequate contraception (as determined by the treating physician) are excluded from participation.

This study involves radiation therapy (WBI) that has known genotoxic, mutagenic and teratogenic effects.

Size of Single Focus of Disease on Preoperative Imaging - Largest single focus of disease > 5 centimeters by either mammogram or MRI or both. Note: Measurement of the largest single focus should include any satellite lesions within 1 centimeter of the index lesion.
Prior Staging Procedure - Surgical axillary staging procedure prior to first definitive breast operation. Note: FNA or core needle biopsy of axillary node is permitted.
Evidence of Metastatic Disease - Clinical or radiographic evidence of metastatic disease
Prior History of Breast Cancer - Prior history of ipsilateral breast cancer [DCIS, LCIS (lobular cancer in situ) or invasive]
Staging of Cancer - cNX, cN2, or cN3 disease
Breast Implants - Breast implants at time of diagnosis. Note: Patients who have had implants previously removed prior to diagnosis are eligible.
Systemic Illnesses or Concurrent Disease - Co-morbid systemic illnesses or other severe concurrent disease which, in the judgment of the investigator, would interfere significantly with whole breast irradiation (such as connective tissue disorders, lupus, scleroderma).
Uncontrolled Intercurrent Illness - Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
Bilateral Breast Cancer - Prior or current LCIS, DCIS or invasive breast cancer in the opposite breast (i.e., bilateral disease is not allowed).
Disallowed Prior Treatments - Treatment including radiation therapy, chemotherapy, biotherapy, hormonal therapy for this cancer prior to surgery (i.e., any neoadjuvant chemotherapy or endocrine therapy is not allowed). Patients who undergo surgical resection with breast conservation and then are treated with adjuvant systemic therapy are eligible to enroll prior to the start of radiotherapy.
Partial Breast Radiation - Planned partial breast radiation.
Known BRCA Mutations - Patients with known BRCA mutations. Patients who are not tested or whose testing result is not returned at the time of registration are not excluded from registering to this study.
Other Active Malignancies - Other active malignancy ≤ 5 years prior to registration.

14.1 Exceptions: Non-melanotic skin cancer or carcinoma-in-situ of the cervix.

14.2 Note: If there is a history of prior malignancy, they must not be receiving other specific treatment for their cancer.

Study is for people with:

Breast Cancer

Phase:

Phase 2

Estimated Enrollment:

270

Study ID:

NCT01556243

Recruitment Status:

Completed

Sponsor:

Alliance for Clinical Trials in Oncology

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There are 280 Locations for this study

See Locations Near You

CHI Saint Vincent Cancer Center Hot Springs
Hot Springs Arkansas, 71913, United States
Epic Care-Dublin
Dublin California, 94568, United States
Bay Area Breast Surgeons, Incorporated
Emeryville California, 94608, United States
Epic Care Partners in Cancer Care
Emeryville California, 94608, United States
UC San Diego Moores Cancer Center
La Jolla California, 92093, United States
Cedars Sinai Medical Center
Los Angeles California, 90048, United States
Cedars-Sinai Medical Center
Los Angeles California, 90048, United States
Contra Costa Regional Medical Center
Martinez California, 94553, United States
Alta Bates Summit Medical Center-Summit Campus
Oakland California, 94609, United States
Bay Area Tumor Institute
Oakland California, 94609, United States
Stanford Cancer Institute
Palo Alto California, 94304, United States
Naval Medical Center-San Diego
San Diego California, 92134, United States
University of Colorado Cancer Center-Anschutz Cancer Pavilion
Aurora Colorado, 80045, United States
Catholic Health Initiatives NCORP
Englewood Colorado, 80112, United States
Smilow Cancer Hospital Care Center at Saint Francis
Hartford Connecticut, 06105, United States
Beebe Medical Center
Lewes Delaware, 19958, United States
Christiana Gynecologic Oncology LLC
Newark Delaware, 19713, United States
Delaware Clinical and Laboratory Physicians PA
Newark Delaware, 19713, United States
Helen F. Graham Cancer Center
Newark Delaware, 19713, United States
Medical Oncology Hematology Consultants PA
Newark Delaware, 19713, United States
Regional Hematology and Oncology PA
Newark Delaware, 19713, United States
Christiana Care Health System-Christiana Hospital
Newark Delaware, 19718, United States
Beebe Health Campus
Rehoboth Beach Delaware, 19971, United States
Nanticoke Memorial Hospital
Seaford Delaware, 19973, United States
Christiana Care Health System-Wilmington Hospital
Wilmington Delaware, 19801, United States
Morton Plant Hospital
Clearwater Florida, 33756, United States
Mount Sinai Medical Center
Miami Beach Florida, 33140, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami Florida, 33136, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah Georgia, 31405, United States
Oncare Hawaii, Incorporated-Pali Momi
'Aiea Hawaii, 96701, United States
Pali Momi Medical Center
'Aiea Hawaii, 96701, United States
The Cancer Center of Hawaii-Leeward
'Ewa Beach Hawaii, 96706, United States
Oncare Hawaii Inc-POB II
Honolulu Hawaii, 96813, United States
Queen's Medical Center
Honolulu Hawaii, 96813, United States
Straub Clinic and Hospital
Honolulu Hawaii, 96813, United States
University of Hawaii Cancer Center
Honolulu Hawaii, 96813, United States
Kuakini Medical Center
Honolulu Hawaii, 96817, United States
OnCare Hawaii, Incorporated-Kuakini
Honolulu Hawaii, 96817, United States
OnCare Hawaii-Liliha
Honolulu Hawaii, 96817, United States
The Cancer Center of Hawaii-Liliha
Honolulu Hawaii, 96817, United States
Kapiolani Medical Center for Women and Children
Honolulu Hawaii, 96826, United States
Wilcox Memorial Hospital and Kauai Medical Clinic
Lihue Hawaii, 96766, United States
Saint Alphonsus Cancer Care Center-Boise
Boise Idaho, 83706, United States
Kootenai Medical Center
Coeur d'Alene Idaho, 83814, United States
Kootenai Cancer Center
Post Falls Idaho, 83854, United States
Kootenai Cancer Clinic
Sandpoint Idaho, 83864, United States
Saint Joseph Medical Center
Bloomington Illinois, 61701, United States
Illinois CancerCare-Bloomington
Bloomington Illinois, 61704, United States
Illinois CancerCare-Canton
Canton Illinois, 61520, United States
Memorial Hospital of Carbondale
Carbondale Illinois, 62902, United States
Illinois CancerCare-Carthage
Carthage Illinois, 62321, United States
Centralia Oncology Clinic
Centralia Illinois, 62801, United States
University of Illinois
Chicago Illinois, 60612, United States
Cancer Care Specialists of Central Illinois
Decatur Illinois, 62526, United States
Decatur Memorial Hospital
Decatur Illinois, 62526, United States
Crossroads Cancer Center
Effingham Illinois, 62401, United States
Illinois CancerCare-Eureka
Eureka Illinois, 61530, United States
Illinois CancerCare-Galesburg
Galesburg Illinois, 61401, United States
Western Illinois Cancer Treatment Center
Galesburg Illinois, 61401, United States
Ingalls Memorial Hospital
Harvey Illinois, 60426, United States
Illinois CancerCare-Kewanee Clinic
Kewanee Illinois, 61443, United States
Illinois CancerCare-Macomb
Macomb Illinois, 61455, United States
Illinois CancerCare-Ottawa Clinic
Ottawa Illinois, 61350, United States
Radiation Oncology of Northern Illinois
Ottawa Illinois, 61350, United States
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
Pekin Illinois, 61554, United States
Illinois CancerCare-Pekin
Pekin Illinois, 61603, United States
Methodist Medical Center of Illinois
Peoria Illinois, 61603, United States
Illinois CancerCare-Peoria
Peoria Illinois, 61615, United States
OSF Saint Francis Radiation Oncology at Peoria Cancer Center
Peoria Illinois, 61615, United States
OSF Saint Francis Medical Center
Peoria Illinois, 61637, United States
Illinois CancerCare-Peru
Peru Illinois, 61354, United States
Valley Radiation Oncology
Peru Illinois, 61354, United States
Illinois CancerCare-Princeton
Princeton Illinois, 61356, United States
Central Illinois Hematology Oncology Center
Springfield Illinois, 62702, United States
Southern Illinois University School of Medicine
Springfield Illinois, 62702, United States
Springfield Clinic
Springfield Illinois, 62703, United States
Memorial Medical Center
Springfield Illinois, 62781, United States
Cancer Care Specialists of Illinois-Swansea
Swansea Illinois, 62226, United States
IU Health West Hospital
Avon Indiana, 46123, United States
IU Health North Hospital
Carmel Indiana, 46032, United States
IU Health Central Indiana Cancer Centers-Fishers
Fishers Indiana, 46037, United States
Indiana University-Melvin and Bren Simon Cancer Center
Indianapolis Indiana, 46202, United States
IU Health Methodist Hospital
Indianapolis Indiana, 46202, United States
Sidney and Lois Eskenazi Hospital
Indianapolis Indiana, 46202, United States
Memorial Regional Cancer Center-Day Road
Mishawaka Indiana, 46544, United States
Saint Joseph Regional Medical Center-Mishawaka
Mishawaka Indiana, 46545, United States
Memorial Hospital of South Bend
South Bend Indiana, 46601, United States
Michiana Hematology Oncology PC-South Bend
South Bend Indiana, 46601, United States
Mary Greeley Medical Center
Ames Iowa, 50010, United States
McFarland Clinic PC-William R Bliss Cancer Center
Ames Iowa, 50010, United States
McFarland Clinic PC-Boone
Boone Iowa, 50036, United States
Medical Oncology and Hematology Associates-West Des Moines
Clive Iowa, 50325, United States
Mercy Cancer Center-West Lakes
Clive Iowa, 50325, United States
Alegent Health Mercy Hospital
Council Bluffs Iowa, 51503, United States
Greater Regional Medical Center
Creston Iowa, 50801, United States
Iowa Methodist Medical Center
Des Moines Iowa, 50309, United States
Iowa-Wide Oncology Research Coalition NCORP
Des Moines Iowa, 50309, United States
Medical Oncology and Hematology Associates-Des Moines
Des Moines Iowa, 50309, United States
Medical Oncology and Hematology Associates-Laurel
Des Moines Iowa, 50314, United States
Mercy Medical Center-Des Moines
Des Moines Iowa, 50314, United States
Iowa Lutheran Hospital
Des Moines Iowa, 50316, United States
McFarland Clinic PC-Trinity Cancer Center
Fort Dodge Iowa, 50501, United States
McFarland Clinic PC-Jefferson
Jefferson Iowa, 50129, United States
McFarland Clinic PC-Marshalltown
Marshalltown Iowa, 50158, United States
Mercy Medical Center-West Lakes
West Des Moines Iowa, 50266, United States
Methodist West Hospital
West Des Moines Iowa, 50266, United States
Menorah Medical Center
Overland Park Kansas, 66209, United States
Saint Luke's South Hospital
Overland Park Kansas, 66213, United States
Kansas City NCI Community Oncology Research Program
Prairie Village Kansas, 66208, United States
Flaget Memorial Hospital
Bardstown Kentucky, 40004, United States
Commonwealth Cancer Center-Corbin
Corbin Kentucky, 40701, United States
Saint Elizabeth Medical Center South
Edgewood Kentucky, 41017, United States
Saint Elizabeth-Fort Thomas
Fort Thomas Kentucky, 41075, United States
Saint Joseph Radiation Oncology Resource Center
Lexington Kentucky, 40504, United States
Saint Joseph Hospital East
Lexington Kentucky, 40509, United States
Jewish Hospital
Louisville Kentucky, 40202, United States
The James Graham Brown Cancer Center at University of Louisville
Louisville Kentucky, 40202, United States
Saints Mary and Elizabeth Hospital
Louisville Kentucky, 40215, United States
Jewish Hospital Medical Center Northeast
Louisville Kentucky, 40245, United States
Jewish Hospital Medical Center South
Shepherdsville Kentucky, 40165, United States
Eastern Maine Medical Center
Bangor Maine, 04401, United States
Eastern Maine Medical Center Cancer Care
Brewer Maine, 04412, United States
Sinai Hospital of Baltimore
Baltimore Maryland, 21215, United States
Saint Agnes Hospital
Baltimore Maryland, 21229, United States
Dana-Farber Cancer Institute
Boston Massachusetts, 02115, United States
Dana-Farber/Brigham and Women's Cancer Center at South Shore
South Weymouth Massachusetts, 02190, United States
Saint Joseph Mercy Hospital
Ann Arbor Michigan, 48106, United States
Bronson Battle Creek
Battle Creek Michigan, 49017, United States
Oakwood Hospital and Medical Center
Dearborn Michigan, 48124, United States
Wayne State University/Karmanos Cancer Institute
Detroit Michigan, 48201, United States
Saint John Hospital and Medical Center
Detroit Michigan, 48236, United States
Genesys Hurley Cancer Institute
Flint Michigan, 48503, United States
Hurley Medical Center
Flint Michigan, 48503, United States
Mercy Health Saint Mary's
Grand Rapids Michigan, 49503, United States
Spectrum Health at Butterworth Campus
Grand Rapids Michigan, 49503, United States
Allegiance Health
Jackson Michigan, 49201, United States
Borgess Medical Center
Kalamazoo Michigan, 49001, United States
Bronson Methodist Hospital
Kalamazoo Michigan, 49007, United States
West Michigan Cancer Center
Kalamazoo Michigan, 49007, United States
Sparrow Hospital
Lansing Michigan, 48912, United States
Saint Mary Mercy Hospital
Livonia Michigan, 48154, United States
Mercy Health Mercy Campus
Muskegon Michigan, 49444, United States
Saint Joseph Mercy Oakland
Pontiac Michigan, 48341, United States
William Beaumont Hospital-Royal Oak
Royal Oak Michigan, 48073, United States
Saint Mary's of Michigan
Saginaw Michigan, 48601, United States
Munson Medical Center
Traverse City Michigan, 49684, United States
William Beaumont Hospital-Troy
Troy Michigan, 48098, United States
Saint John Macomb-Oakland Hospital
Warren Michigan, 48093, United States
Fairview Ridges Hospital
Burnsville Minnesota, 55337, United States
Mercy Hospital
Coon Rapids Minnesota, 55433, United States
Fairview-Southdale Hospital
Edina Minnesota, 55435, United States
Unity Hospital
Fridley Minnesota, 55432, United States
Minnesota Oncology Hematology PA-Maplewood
Maplewood Minnesota, 55109, United States
Saint John's Hospital-Healtheast
Maplewood Minnesota, 55109, United States
Abbott-Northwestern Hospital
Minneapolis Minnesota, 55407, United States
Hennepin County Medical Center
Minneapolis Minnesota, 55415, United States
Health Partners Inc
Minneapolis Minnesota, 55454, United States
New Ulm Medical Center
New Ulm Minnesota, 56073, United States
North Memorial Medical Health Center
Robbinsdale Minnesota, 55422, United States
Mayo Clinic Cancer Center
Rochester Minnesota, 55905, United States
Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud Minnesota, 56303, United States
Saint Cloud Hospital
Saint Cloud Minnesota, 56303, United States
Metro Minnesota Community Oncology Research Consortium
Saint Louis Park Minnesota, 55416, United States
Park Nicollet Clinic-Saint Louis Park
Saint Louis Park Minnesota, 55416, United States
Regions Hospital
Saint Paul Minnesota, 55101, United States
United Hospital
Saint Paul Minnesota, 55102, United States
Saint Francis Regional Medical Center
Shakopee Minnesota, 55379, United States
Lakeview Hospital
Stillwater Minnesota, 55082, United States
Ridgeview Medical Center
Waconia Minnesota, 55387, United States
Rice Memorial Hospital
Willmar Minnesota, 56201, United States
Minnesota Oncology and Hematology PA-Woodbury
Woodbury Minnesota, 55125, United States
Parkland Health Center-Bonne Terre
Bonne Terre Missouri, 63628, United States
Saint Francis Medical Center
Cape Girardeau Missouri, 63703, United States
Southeast Cancer Center
Cape Girardeau Missouri, 63703, United States
Centerpoint Medical Center LLC
Independence Missouri, 64057, United States
Capital Region Medical Center-Goldschmidt Cancer Center
Jefferson City Missouri, 65109, United States
Saint Luke's Hospital of Kansas City
Kansas City Missouri, 64111, United States
Heartland Hematology and Oncology Associates Incorporated
Kansas City Missouri, 64118, United States
Research Medical Center
Kansas City Missouri, 64132, United States
Saint Luke's East-Lee's Summit
Lee's Summit Missouri, 64086, United States
Liberty Radiation Oncology Center
Liberty Missouri, 64068, United States
Washington University School of Medicine
Saint Louis Missouri, 63110, United States
Missouri Baptist Medical Center
Saint Louis Missouri, 63131, United States
Sainte Genevieve County Memorial Hospital
Sainte Genevieve Missouri, 63670, United States
Missouri Baptist Sullivan Hospital
Sullivan Missouri, 63080, United States
Missouri Baptist Outpatient Center-Sunset Hills
Sunset Hills Missouri, 63127, United States
Montana Cancer Consortium NCORP
Billings Montana, 59101, United States
Saint Vincent Healthcare
Billings Montana, 59101, United States
Billings Clinic Cancer Center
Billings Montana, 59107, United States
Bozeman Deaconess Hospital
Bozeman Montana, 59715, United States
Saint James Community Hospital and Cancer Treatment Center
Butte Montana, 59701, United States
Benefis Healthcare-Sletten Cancer Institute
Great Falls Montana, 59405, United States
Saint Peter's Community Hospital
Helena Montana, 59601, United States
Kalispell Regional Medical Center
Kalispell Montana, 59901, United States
Community Medical Hospital
Missoula Montana, 59801, United States
Saint Patrick Hospital-Community Hospital
Missoula Montana, 59802, United States
CHI Health Saint Francis
Grand Island Nebraska, 68803, United States
Heartland Hematology and Oncology
Kearney Nebraska, 68845, United States
CHI Health Good Samaritan
Kearney Nebraska, 68847, United States
Saint Elizabeth Regional Medical Center
Lincoln Nebraska, 68510, United States
Alegent Health Immanuel Medical Center
Omaha Nebraska, 68122, United States
Hematology and Oncology Consultants PC
Omaha Nebraska, 68122, United States
Alegent Health Bergan Mercy Medical Center
Omaha Nebraska, 68124, United States
Alegent Health Lakeside Hospital
Omaha Nebraska, 68130, United States
Creighton University Medical Center
Omaha Nebraska, 68131, United States
Midlands Community Hospital
Papillion Nebraska, 68046, United States
Cancer and Blood Specialists-Henderson
Henderson Nevada, 89052, United States
Comprehensive Cancer Centers of Nevada-Henderson
Henderson Nevada, 89052, United States
Las Vegas Cancer Center-Henderson
Henderson Nevada, 89052, United States
21st Century Oncology-Henderson
Henderson Nevada, 89074, United States
Comprehensive Cancer Centers of Nevada-Southeast Henderson
Henderson Nevada, 89074, United States
University Medical Center of Southern Nevada
Las Vegas Nevada, 89102, United States
Cancer and Blood Specialists-Shadow
Las Vegas Nevada, 89106, United States
Nevada Cancer Research Foundation NCORP
Las Vegas Nevada, 89106, United States
Radiation Oncology Centers of Nevada Central
Las Vegas Nevada, 89106, United States
21st Century Oncology-Fort Apache
Las Vegas Nevada, 89109, United States
21st Century Oncology
Las Vegas Nevada, 89109, United States
HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
Las Vegas Nevada, 89109, United States
HealthCare Partners Medical Group Oncology/Hematology-San Martin
Las Vegas Nevada, 89113, United States
Radiation Oncology Centers of Nevada Southeast
Las Vegas Nevada, 89119, United States
Cancer Therapy and Integrative Medicine
Las Vegas Nevada, 89121, United States
21st Century Oncology-Vegas Tenaya
Las Vegas Nevada, 89128, United States
Cancer and Blood Specialists-Tenaya
Las Vegas Nevada, 89128, United States
Comprehensive Cancer Centers of Nevada-Northwest
Las Vegas Nevada, 89128, United States
HealthCare Partners Medical Group Oncology/Hematology-Tenaya
Las Vegas Nevada, 89128, United States
Comprehensive Cancer Centers of Nevada-Summerlin
Las Vegas Nevada, 89144, United States
Cancer and Blood Specialists-Fort Apache
Las Vegas Nevada, 89148, United States
Comprehensive Cancer Centers of Nevada
Las Vegas Nevada, 89148, United States
Las Vegas Cancer Center-Medical Center
Las Vegas Nevada, 89148, United States
HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
Las Vegas Nevada, 89149, United States
Comprehensive Cancer Centers of Nevada-Central Valley
Las Vegas Nevada, 89169, United States
Dartmouth Hitchcock Medical Center
Lebanon New Hampshire, 03756, United States
Memorial Sloan Kettering Cancer Center-Basking Ridge
Basking Ridge New Jersey, 07920, United States
Saint Peter's University Hospital
New Brunswick New Jersey, 08901, United States
University of New Mexico Cancer Center
Albuquerque New Mexico, 87102, United States
Lovelace Women's Hospital
Albuquerque New Mexico, 87109, United States
Memorial Sloan Kettering Cancer Center-Commack
Commack New York, 11725, United States
Memorial Sloan Kettering Cancer Center-West Harrison
Harrison New York, 10604, United States
North Shore University Hospital
Manhasset New York, 11030, United States
North Shore-LIJ Health System/Center for Advanced Medicine
New Hyde Park New York, 11040, United States
Memorial Sloan Kettering Cancer Center
New York New York, 10065, United States
Vassar Brothers Medical Center
Poughkeepsie New York, 12601, United States
University of Rochester
Rochester New York, 14642, United States
Memorial Sloan Kettering Cancer Center-Rockville Centre
Rockville Centre New York, 11570, United States
Memorial Sloan Kettering Cancer Center-Sleepy Hollow
Sleepy Hollow New York, 10591, United States
Randolph Hospital
Asheboro North Carolina, 27203, United States
Carolinas Medical Center/Levine Cancer Institute
Charlotte North Carolina, 28203, United States
Levine Cancer Institute-Tryon
Charlotte North Carolina, 28203, United States
Novant Health Presbyterian Medical Center
Charlotte North Carolina, 28204, United States
Carolina Surgical Clinic of Charlotte PA
Charlotte North Carolina, 28207, United States
Oncology Specialists of Charlotte
Charlotte North Carolina, 28207, United States
Carolinas Medical Center/Levine Cancer Institute-Pineville
Charlotte North Carolina, 28210, United States
Carolinas Medical Center/Levine Cancer Institute-University
Charlotte North Carolina, 28262, United States
Southern Oncology Specialists-Charlotte
Charlotte North Carolina, 28262, United States
Levine Cancer Institute-Ballantyne
Charlotte North Carolina, 28277, United States
CaroMont Breast Surgical Specialists-Gastonia
Gastonia North Carolina, 28054, United States
CaroMont Regional Medical Center
Gastonia North Carolina, 28054, United States
Cone Health Cancer Center
Greensboro North Carolina, 27403, United States
Lake Norman Hematology Oncology Specialists-Huntersville
Huntersville North Carolina, 28078, United States
Southern Oncology Specialists-Huntersville
Huntersville North Carolina, 28078, United States
Matthews Radiation Oncology Center
Matthews North Carolina, 28105, United States
Novant Health Cancer Specialists-Matthews
Matthews North Carolina, 28105, United States
Carolinas HealthCare System Union
Monroe North Carolina, 28112, United States
Lake Norman Hematology Oncology Specialists-Mooresville
Mooresville North Carolina, 28117, United States
Annie Penn Memorial Hospital
Reidsville North Carolina, 27320, United States
Strecker Cancer Center-Belpre
Belpre Ohio, 45714, United States
Adena Regional Medical Center
Chillicothe Ohio, 54601, United States
The Christ Hospital
Cincinnati Ohio, 45219, United States
Good Samaritan Hospital-Cincinnati
Cincinnati Ohio, 45220, United States
Bethesda North Hospital
Cincinnati Ohio, 45242, United States
TriHealth Cancer Institute-Westside
Cincinnati Ohio, 45247, United States
TriHealth Cancer Institute-Anderson
Cincinnati Ohio, 45255, United States
University of Cincinnati
Cincinnati Ohio, 45267, United States
Mount Carmel East Hospital
Columbus Ohio, 43213, United States
Columbus Oncology and Hematology Associates Inc
Columbus Ohio, 43214, United States
Riverside Methodist Hospital
Columbus Ohio, 43214, United States
Columbus NCI Community Oncology Research Program
Columbus Ohio, 43215, United States
Grant Medical Center
Columbus Ohio, 43215, United States
The Mark H Zangmeister Center
Columbus Ohio, 43219, United States
Mount Carmel Health Center West
Columbus Ohio, 43222, United States
Doctors Hospital
Columbus Ohio, 43228, United States
Delaware Health Center-Grady Cancer Center
Delaware Ohio, 43015, United States
Delaware Radiation Oncology
Delaware Ohio, 43015, United States
Grady Memorial Hospital
Delaware Ohio, 43015, United States
Fairfield Medical Center
Lancaster Ohio, 43130, United States
OhioHealth MedCentral Hospital
Mansfield Ohio, 44903, United States
Marietta Memorial Hospital
Marietta Ohio, 45750, United States
OhioHealth Marion General Hospital
Marion Ohio, 43302, United States
Knox Community Hospital
Mount Vernon Ohio, 43050, United States
Licking Memorial Hospital
Newark Ohio, 43055, United States
Newark Radiation Oncology
Newark Ohio, 43055, United States
Southern Ohio Medical Center
Portsmouth Ohio, 45662, United States
Springfield Regional Medical Center
Springfield Ohio, 45505, United States
University Pointe
West Chester Ohio, 45069, United States
Saint Ann's Hospital
Westerville Ohio, 43081, United States
Genesis Healthcare System Cancer Care Center
Zanesville Ohio, 43701, United States
University of Oklahoma Health Sciences Center
Oklahoma City Oklahoma, 73104, United States
Mercy Hospital Oklahoma City
Oklahoma City Oklahoma, 73120, United States
Oregon Health and Science University
Portland Oregon, 97239, United States
Lehigh Valley Hospital-Cedar Crest
Allentown Pennsylvania, 18103, United States
Lehigh Valley Hospital-Muhlenberg
Bethlehem Pennsylvania, 18017, United States
Bryn Mawr Hospital
Bryn Mawr Pennsylvania, 19010, United States
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh Pennsylvania, 15232, United States
Lankenau Medical Center
Wynnewood Pennsylvania, 19096, United States
Roger Williams Medical Center
Providence Rhode Island, 02908, United States
Hilton Head Regional Medical Center
Hilton Head Island South Carolina, 29926, United States
Levine Cancer Institute-Rock Hill
Rock Hill South Carolina, 29732, United States
Lexington Medical Center
West Columbia South Carolina, 29169, United States
Avera Cancer Institute
Sioux Falls South Dakota, 57105, United States
Memorial Hospital
Chattanooga Tennessee, 37404, United States
Pulmonary Medicine Center of Chattanooga-Hixson
Hixson Tennessee, 37343, United States
Memorial GYN Plus
Ooltewah Tennessee, 37363, United States
Texas Tech University Health Sciences Center-Amarillo
Amarillo Texas, 79106, United States
Parkland Memorial Hospital
Dallas Texas, 75235, United States
UT Southwestern/Simmons Cancer Center-Dallas
Dallas Texas, 75390, United States
M. D. Anderson Cancer Center
Houston Texas, 77030, United States
The Methodist Hospital System
Houston Texas, 77030, United States
Doctor's Hospital of Laredo
Laredo Texas, 78045, United States
Huntsman Cancer Institute/University of Utah
Salt Lake City Utah, 84112, United States
Central Vermont Medical Center
Berlin Vermont, 05602, United States
University of Vermont College of Medicine
Burlington Vermont, 05405, United States
Norris Cotton Cancer Center-North
Saint Johnsbury Vermont, 05819, United States
Mary Washington Hospital
Fredericksburg Virginia, 22401, United States
Virginia Commonwealth University/Massey Cancer Center
Richmond Virginia, 23298, United States
Harrison HealthPartners Hematology and Oncology-Bremerton
Bremerton Washington, 98310, United States
Harrison Medical Center
Bremerton Washington, 98310, United States
Highline Medical Center-Main Campus
Burien Washington, 98166, United States
Saint Elizabeth Hospital
Enumclaw Washington, 98022, United States
Saint Francis Hospital
Federal Way Washington, 98003, United States
Saint Clare Hospital
Lakewood Washington, 98499, United States
Harrison HealthPartners Hematology and Oncology-Poulsbo
Poulsbo Washington, 98370, United States
Virginia Mason Medical Center
Seattle Washington, 98101, United States
Franciscan Research Center-Northwest Medical Plaza
Tacoma Washington, 98405, United States
Northwest Medical Specialties PLLC
Tacoma Washington, 98405, United States
Green Bay Oncology at Saint Vincent Hospital
Green Bay Wisconsin, 54301, United States
Saint Vincent Hospital
Green Bay Wisconsin, 54301, United States
Green Bay Oncology Limited at Saint Mary's Hospital
Green Bay Wisconsin, 54303, United States
Saint Mary's Hospital
Green Bay Wisconsin, 54303, United States
Aurora BayCare Medical Center
Green Bay Wisconsin, 54311, United States
Gundersen Lutheran Medical Center
La Crosse Wisconsin, 54601, United States
Aurora Saint Luke's Medical Center
Milwaukee Wisconsin, 53215, United States
Froedtert and the Medical College of Wisconsin
Milwaukee Wisconsin, 53226, United States
Aurora Sinai Medical Center
Milwaukee Wisconsin, 53233, United States
Westfields Hospital/Cancer Center of Western Wisconsin
New Richmond Wisconsin, 54017, United States
Vince Lombardi Cancer Clinic-Oshkosh
Oshkosh Wisconsin, 54904, United States
Aurora Medical Center in Summit
Summit Wisconsin, 53066, United States
Aurora West Allis Medical Center
West Allis Wisconsin, 53227, United States
Big Horn Basin Cancer Center
Cody Wyoming, 82414, United States
Billings Clinic-Cody
Cody Wyoming, 82414, United States
Welch Cancer Center
Sheridan Wyoming, 82801, United States

How clear is this clinincal trial information?

Study is for people with:

Breast Cancer

Phase:

Phase 2

Estimated Enrollment:

270

Study ID:

NCT01556243

Recruitment Status:

Completed

Sponsor:


Alliance for Clinical Trials in Oncology

How clear is this clinincal trial information?

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