Breast Cancer Clinical Trial
Breast MRI Screening in Women Treated With Mediastinal Irradiation for Hodgkin’s Disease
Summary
The purpose of this study is to determine if the use of breast MRI in detecting breast malignancies in survivors of Hodgkin's disease is more successful than the traditional mammogram.
Full Description
The screening breast MRI and mammography will be performed 6 months or longer after the last mammogram. For pre-menopausal women, the screening will be performed during the second week of the menstrual cycle to reduce cycle-related breast changes. As much as possible, the breast MRI and mammogram are to be performed on the same day.
On the day of the breast imaging studies, the patient will also be asked to fill out a baseline breast health questionnaire, which includes questions on time since radiation therapy, prior screening history, history of prior benign breast biopsies, menopausal status, prior hormonal therapy use, etc.
In patients with suspicious findings or findings highly suggestive of malignancy, the abnormal findings will be reviewed with the patient and recommendations will be made for a biopsy.
Eligibility Criteria
Inclusion Criteria:
Female patients treated with radiation therapy to the chest area for Hodgkin's disease
Age between 12 and 35 at initial treatment
Eight years or longer after initial treatment
Pre-approval from the participant's insurance company for the breast imaging studies
Exclusion Criteria:
Pregnant or lactating women
Post Bilateral mastectomy
Currently undergoing breast cancer therapy
Known metastatic cancer
Patients with contraindications for undergoing an MRI: cardiac pacemaker, known metallic objects in body e.g. metallic clips, bullets, shrapnel or buckshots.
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There are 2 Locations for this study
Boston Massachusetts, 02115, United States
Boston Massachusetts, 02115, United States
Boston Massachusetts, 02215, United States
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