CAREFOR: Precision Medicine Driving Precision Nutrition for the Treatment of NeoAdjuvant Breast Cancer

Inclusion Criteria:

Pathologically proven invasive breast cancer
Planned neoadjuvant chemotherapy determined by the judgment of the medical oncologist
The patient must be female
Age ≥ 18
Non-metastatic and non-inflammatory breast cancer
History/physical examination, including breast exam and documentation of weight and Karnofsky Performance Status of 80-100% for at least 60 days prior to study entry.
Women of childbearing potential must be non-pregnant and non-lactating and willing to use medically acceptable form of contraception during chemotherapy
Patient must capable of and provide study specific informed consent prior to study entry
BMI ≥21
Weight ≥120lbs
No prior history of non-breast malignancies in the past 1 year unless it was a non- melanomatous skin lesion or carcinoma in situ of the cervix.
Patient must not have Acquired Immune Deficiency Syndrome (AIDS) or HIV positive based upon current CDC definition; note, however, that HIV testing is not required for entry into this protocol. The need to exclude patients with AIDS or HIV from this protocol is necessary because anti-retrovirals may alter patient metabolism.
Patient may not have any active Gastrointestinal/Malabsorption disorder at the discretion of the Principal Investigator which may include:
Chronic Pancreatitis
Chronic Diarrhea or Vomiting
Active Eating Disorder
No history of or current active drug/alcohol dependence.
No patients with decisional impairment.

Exclusion Criteria:

Patient is male.
Age <18 years
Clinical stage IV cancer
Inflammatory breast cancer (T4d)
Women of childbearing potential with a positive serum beta hCG.
Decision impaired patients.
BMI < 21
Weight < 120lbs
Weight loss ≥10% in the last 3 mos
Prior invasive non-breast malignancy (except non-melanomatous skin cancer, carcinoma in situ of the cervix) unless disease free for a minimum of 1 year prior to registration
Non-epithelial breast malignancies such as sarcoma or lymphoma

Active Gastrointestinal/Malabsorption disorder at the discretion of the Principal -Investigator which may include:

Chronic Diarrhea or Vomiting
Active Eating Disorder
Active drug/alcohol dependence or abuse history.