Cathepsin Activatable Fluorescent Probe

Inclusion Criteria:

18 years of age or older
Diagnosis of soft tissue sarcoma and breast cancer patients scheduled for a lumpectomy or mastectomy.
Subjects must be scheduled for surgical resection of a tumor at least 1 cm in size.
Performance status of 0 or 1
Able to read, understand and sign an informed consent form
Must be able and willing to follow study procedures and instructions including a possible overnight stay before surgery
Otherwise healthy except for the diagnosis of cancer
ALT, AST, and total bilirubin within 1.5x institutional upper normal limits; and alkaline phosphatase within 2.5x institutional upper normal limits
Serum creatinine of 1.5 mg or less; creatinine clearance greater than 30 ml/min
May have previously received pre-operative external beam radiation therapy for this sarcoma

Exclusion Criteria:

Pregnant or lactating
Prolonged QT interval: corrected QT interval (QTc) > 480 msec
Insulin dependent diabetes
History of anaphylactic reactions to any drug or contrast agent
Asthma under medical management
Uncontrolled high blood pressure
Severe, active co-morbidity
Known substance addiction
Sexually active and not willing/able to use medically acceptable forms of contraception.
Obesity defined as BMI as body mass index greater than 35 kg/meter squared.
Atopy or atopic syndrome
Known AIDS
Cannot have taken an investigational drug within 30 days of coming onto this study