Clinical Trial of Gemcitabine and Oxaliplatin in Recurrent or Metastatic Breast Cancer

Inclusion Criteria:

Histologically proven dx of recurrent or metastatic breast cancer
Must have received at least 1 but not more than 3 prior chemotherapy regimens for recurrent or metastatic breast cancer. Patients who relapse within 12 months of completing adjuvant chemotherapy can only have had up to 2 prior regimens for metastatic disease. Patients who relapse within 12 months of completing adjuvant chemotherapy containing an anthracycline and a taxane, do not require prior chemotherapy for metastatic disease.
Unidimensionally measurable dz (by RECIST)
At least 18 yrs of age
SWOG PS 0-2
AGC greater than or equal to 1.5; platelets greater than or equal to 100,000; Hgb greater than or equal to 8.0
Total bilirubin less than or equal to 2 x uln; SGOT and/or SGPT and alk phos up to 2.5 x uln
Creatinine less than or equal to 2.0
Fully recovered from acute toxicities secondary to prior tx
Signed informed consent (including HIPAA authorization)
Peripheral neuropathy grade 0-1

Exclusion Criteria

Prior tx with gemcitabine or oxaliplatin. Prior tx with cisplatin or carboplatin allowed if completed >12 mos prior to enrollment.
Underlying medical, psychiatric, or social conditions that would preclude patient from receiving tx
Peripheral neuropathy greater than or equal to Gr 2

Exclusion Criteria:

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