Coenzyme Q10 in Relieving Treatment-Related Fatigue in Women With Breast Cancer

Inclusion Criteria:

Signed consent
Hg > 11g/dl; supportive measures (erythropoietin, transfusion, iron therapy) should be utilized to assist with maintaining Hgb levels
Total cholesterol > 160mg/dL.
Female with primary cancer diagnosis (breast)
Planned adjuvant chemotherapy (neoadjuvant chemotherapy is excluded)
KPS > 60
Bilirubin < 1.5 x ULN
SGOT < 2.5 x ULN
SGPT < 2.5 x ULN

Exclusion Criteria:

Recent involuntary weight loss (> 5% of body weight in the past 3 months)

Statin therapy - current or planned during study. Below is a list of some commonly used statin drugs.(Note: This is a helpful guide, not a complete list.)

Atorvastatin (Lipitor)
Cerivastatin
Fluvastatin (Lescol)
Lovastatin (Mevacor, Altocor, Advicor)
Mevastatin
Pravastatin (Pravachol)
Rosuvastatin
Simvastatin (Zocor)

Current or planned use of the following medications for fatigue

Corticosteroids (intermittent use as part of chemotherapy regimen is allowed)
Amphetamines or other stimulants including methylphenidate (Ritalin)or modafinil (Provigil)
Patients diagnosed with uncontrolled hypertension
Breast cancer patients who are male
Pregnant women are excluded from participation in this study. A Serum pregnancy test is required within 1 week of registration if the patient is a woman of childbearing potential.
Anticoagulant therapy - current or planned during study (except for maintenance of catheter patency)
Patients with uncontrolled thyroid dysfunction