Breast Cancer Clinical Trial
Contrast-Enhanced MRI for the Characterization of Ductal Carcinoma in Situ (DCIS)
Summary
RATIONALE: Diagnostic procedures, such as contrast-enhanced MRI, may help find and diagnose ductal carcinoma in situ.
PURPOSE: This study is to develop and refine magnetic resonance (MR) imaging methods for pre-operative staging of ductal carcinoma in situ, a pre-invasive form of breast cancer, and atypical ductal hyperplasia, a risk factor for developing cancer.
Full Description
OBJECTIVES:
Compare the DCIS optimized MRI to the standard clinical MRI. Using a scale of 1-5 from poor to excellent, images will be assessed for conspicuity of DCIS and atypical ductal hyperplasia (ADH) lesions, agreement of disease extent with biopsy, and overall image quality (artifact level, uniformity of fat suppression, contrast to noise ratio and signal to noise ratio).
Subjects with ADH, a benign condition that can also show enhancement on MRI, will be enrolled to explore the utility of the DCIS optimized MRI for distinguishing DCIS and ADH.
Eligibility Criteria
DISEASE CHARACTERISTICS:
Meets 1 of the following criteria:
Patient at the University of California, San Francisco Breast Care Center meeting the following criteria:
Biopsy proven ductal carcinoma in situ (DCIS) of the breast.
Has undergone mammography within the past 60 days.
ADH patients: over 18, no prior history of breast disease.
PATIENT CHARACTERISTICS:
Not pregnant or nursing (or stopped nursing within the past 3 months)
Negative pregnancy test
No contraindication to MRI (e.g., implanted pacemaker, implanted ferromagnetic device, ferromagnetic aneurysm clip, severe claustrophobia, ocular metal fragments, or shrapnel injury)
PRIOR CONCURRENT THERAPY:
More than 2 years since prior surgery to the ipsilateral breast (patient)
No prior radiotherapy to the ipsilateral breast (patient)
No prior cytotoxic regimens (patient)
Check Your Eligibility
Let’s see if you might be eligible for this study.
What is your age and gender ?
There is 1 Location for this study
San Francisco California, 94143, United States More Info
Principal Investigator
How clear is this clinincal trial information?