Breast Cancer Clinical Trial

Dose Dense Carboplatin, Taxotere and Herceptin As Primary Systemic Therapy in Breast Cancer

Summary

Dose dense therapy has been shown to increase survival in the adjuvant setting of breast cancer. It is unknown if dose dense therapy will improve survival in tumors that express her-2. This study evaluates a neoadjuvant regimen containing carboplatin, taxotere and herceptin when used in a dose dense manner in patients with large breast cancers. The endpoint of pathologic complete response is used as a surrogate marker for survival.

View Full Description

Full Description

Dose dense therapy has been shown to increase survival in the adjuvant setting of breast cancer. It is unknown if dose dense therapy will improve survival in tumors that express her-2. This study evaluates a neoadjuvant regimen containing carboplatin, taxotere and herceptin when used in a dose dense manner in patients with large breast cancers. The endpoint of pathologic complete response is used as a surrogate marker for survival.Safety and tolerability assessed by number of grade 4 toxicities and hospitalizations

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

HER-2 overexpressing breast cancer
Clinical stage 2-3B
Normal ejection fraction

Exclusion Criteria:

Metastatic disease
Low ejection fraction

Study is for people with:

Breast Cancer

Phase:

Phase 2

Estimated Enrollment:

48

Study ID:

NCT00232479

Recruitment Status:

Completed

Sponsor:

University of Miami

Check Your Eligibility

Let’s see if you might be eligible for this study.

What is your age and gender ?

Submit

There is 1 Location for this study

See Locations Near You

Jackson Memorial Hospital
Miami Florida, 33136, United States

How clear is this clinincal trial information?

Study is for people with:

Breast Cancer

Phase:

Phase 2

Estimated Enrollment:

48

Study ID:

NCT00232479

Recruitment Status:

Completed

Sponsor:


University of Miami

How clear is this clinincal trial information?

×

Introducing, the Journey Bar

Use this bar to access information about the steps in your cancer journey.

Please confirm you are a US based health care provider:

Yes, I am a health care Provider No, I am not a health care provider