Breast Cancer Clinical Trial
Epigenetics of TNBC in Overweight and Obese Hispanic & Non-Hispanic White Women
Summary
A key tenet of this project is that of reaching translational human diagnosis and biomarker end points. To lay a foundation and make progress towards these translational goals, investigators will address the following specific aim:
To determine if BMI/ obesity differentially influence expression and epigenetic signatures in triple negative breast cancer (TNBC) from Hispanic compared to NHW women.
Full Description
The intended goal of this Project is to develop epigenetic biomarkers to monitor the role of obesity and ethnicity on he development of triple negative breast cancer (TNBC). The proposed approach will seek to clarify for the first time if BMI is a biological factor that regulates aromatic hydrocarbon receptor (AhR) expression and epigenetic activity at breast cancer susceptibility and hormone receptor genes based on Hispanic or non-Hispanic white (NHW) ethnicity. If successful, the proposed experiments have the potential to highlight the role of overweight and obesity for dietary prevention of TNBC and to underscore the consideration of breast cancer screening among overweight/obese Hispanic women. Additionally, this study will provide the opportunity to begin testing the utility of AhR as a biomarker of TNBC development related to BMI and ethnicity.
Eligibility Criteria
Inclusion Criteria:
Hispanic or NHW women
≥ 18 years of age
scheduled for a breast procedure as standard of care treatment - benign breast surgery or prophylactic mastectomy
Newly diagnosed TNBC - Patients with TNBC will be eligible regardless of whether their treatment plan is surgery first or chemotherapy first (neoadjuvant chemotherapy)
Eligible non-white women could be included
Exclusion Criteria:
BRCA1/2 mutation carriers
Family history of breast cancer in a first-degree relative and have NOT had genetic testing for BRCA1/2
Patients who have already undergone radiation or chemotherapy
Pregnant women
Male
Prisoners
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There is 1 Location for this study
Tucson Arizona, 85724, United States
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