Exploratory, Phase 0 Study of Positron Emission Tomography (PET) Imaging Agent, F-18 RGD-K5

Inclusion Criteria:

For Normal Volunteers

Subject is ≥ 18 years old at the time of investigational product administration (Subject is male or female of any race / ethnicity)
Subject or subject's legally acceptable representative provides informed consent
Subject is capable of complying with study procedures
Subject is capable of communicating with study personnel

For Cancer Subjects (same first four bullets as 'normals')

Subject must have had a diagnostic imaging study and is suspected of having a primary or metastatic tumor(s) ( > 2 cm, except breast tumor)-sarcoma; melanoma; lung cancer [including small cell and non-small cell lung cancer (NSCL)]; high grade glioma (including glioblastoma multi-forms), anaplastic astrocytoma, and anaplastic oligodendroglioma; breast carcinomas, and head and neck tumors, including laryngeal squamous cell carcinoma
Subject is scheduled to have a clinical [F-18]FDG PET scan within ± 7 days (with no interventions between the two PET scans) of the investigational, [F-18]RGD-K5 PET scan
Subject is scheduled to undergo resection or biopsy of the target tumor as a result of routine clinical treatment
Subject has not received any anti-angiogenic agents (e.g. bevacizumab, sorafenib, sunitinib) within 10 days prior to PET/CT imaging
Subject has laboratory test results within the following ranges:
AST(SGOT)/ALT(SGPT) ≤ 2.5 x institutional upper limits of normal
Serum creatinine ≤ 1.5 institutional upper limits of normal
Platelet count of > 75,000x106/L
Hemoglobin value of > 9 g/dL
ANC > 1.2 x 106 /mL

Exclusion Criteria 'Normals':

Subject is < 18 at the time of investigational product administration
Female subject is pregnant or nursing:
by testing on site at the institution (serum or urine ßHCG) within 24 hours prior to the investigational product administration
Subject is unable to remain still for duration of imaging procedure
Subject has a history of renal disease
Subject has previously received [F-18]RGD-K5 at any time, or any other investigational product in the past 30 days or will receive any other investigational product within 48 hours after the [F-18]RGD-K5 injection
Subject has not been involved in an investigative, radioactive research procedure or therapeutic procedure within the past 6 months
Subject has any other condition or personal circumstance including severe claustrophobia, severe dyspnea, severe back pain etc, that, in the judgment of the investigator, might interfere with the collection of complete good quality data
Subject has a history of significant prescription or non-prescription drug, or alcohol abuse, including but not limited to marijuana, cocaine, heroin or derivatives.

For Cancer Subjects (first three bullets the same as 'normals')

Subject is < 18 at the time of investigational product administration
Female subject is pregnant or nursing:
by testing on site at the institution (serum or urine ßHCG)
Subject is unable to remain still for duration of imaging procedure
Subject has known hyper or hypo-coagulation syndromes. (e.g., Protein C, S deficiency, Hemophilia A/B/C, Factor-V Leiden, etc.)
Subject has previously received [F-18]RGD-K5 at any time, or any other investigational product in the past 30 days or will receive any other investigational product within 48 hours after the [F-18]RGD-K5 injection.
Subject has inadequate tumor size (< 2 cm , except for breast tumor) or volume to allow for biopsy
Subject has any other condition or personal circumstance including severe claustrophobia, severe dyspnea, severe back pain etc, that, in the judgment of the investigator, might interfere with the collection of complete good quality data
Subject has a history of significant prescription or non-prescription drug, or alcohol abuse, including but not limited to marijuana, cocaine, heroin or derivatives.