Feasibility of High Levels of Energy Expenditure From Physical Activity for Breast Cancer Survivors

Inclusion Criteria:

Women < age 71 in good general health.
Prior diagnosis of breast cancer.
At least 3 months from completion of any cytotoxic chemotherapy or radiation or surgery. May continue to take endocrine therapy and/or maintenance trastuzumab.
Body Mass Index (BMI) 30-45 kg/m2.
By self-assessment, currently performing 60 minutes or less of purposeful exercise per week but able to walk at least 30 minutes on a level surface.
Access to a smart phone capable of running MyFitnessPal and Garmin Connect apps and willing to have diet and exercise data from these apps viewed by study personnel.
Live in the greater Kansas City Metropolitan Area
Willing and able to perform moderate intensity exercise at least 5 days per week for 3 months.
Willing to perform unsupervised home exercise for the entire 3 months.
Willing to participate in a weekly behavioral modification group phone call for 3 months.
Willing to participate in a controlled dietary intervention with portion controlled meals and partial meal and track food intake and exercise.

Exclusion Criteria:

Use of metformin, insulin, steroids or weight loss or anti-psychotic drugs within the prior 3 weeks
Individuals with prior bariatric surgery procedures
Need for chronic immunosuppressive drugs
Participation within the past 6 months on a structured weight loss program such as Weight Watchers®
Physical impairments (bad hip, knees, feet, peripheral neuropathy) that would prohibit performing moderate intensity exercise at least 5 days per week.
Any other condition or intercurrent illness that in the opinion of the investigator makes the subject a poor candidate for participation in the trial such as recent cardiac event.
Currently receiving investigational agents in a clinical trial.