Breast Cancer Clinical Trial

First Time in Human Study of AZD8701 With or Without Durvalumab in Participants With Advanced Solid Tumours

Summary

The purpose of this study is to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, Immunogenicity and Antitumor Activity of AZD8701 Alone and in Combination with Durvalumab (MEDI4736) in Adult Subjects with Select Advanced Solid Tumors

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Full Description

This is a Phase I, First in Human, multicentre, open-label, multiple arm study with dose escalations and expansions at selected doses. Dose-escalation will occur with AZD8701 in monotherapy (Part 1) and in combination with durvalumab (Part 3) in selected participants with HNSCC, TNBC, NSCLC, ccRCC, gastroesophageal cancer, melanoma, cervical cancer, small-cell lung cancer and/or participants with solid tumours who have demonstrated a response to prior PD-(L)1 treatment.

Disease specific expansions will occur with a selected dose of AZD8701 in participants with NSCLC (Part 2) and with a selected dose of AZD8701 and durvalumab in participants with TNBC and clear cell RCC (Part 4).

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

The study is comprised of 2 main parts Monotherapy (AZD8701) and Combined Therapy (AZD8701 and Durvalumab).

Inclusion criteria Dose escalation stages:

Histological or cytological confirmation of a solid, malignant tumour including HNSCC, TNBC, NSCLC, ccRCC, gastroesophageal cancer, melanoma, cervical cancer, SCLC, and/or participants with other solid tumours who have demonstrated a response to prior anti-PD-(L)1 treatment
Participant with progressive disease that is refractory to standard therapies or for which no standard therapies exist and a clinical trial is the best option for next treatment based on prior response and/or tolerability to standard of care

Inclusion Criteria Dose Expansions:

Non Small Lung Cancer Participants who have received prior PD(L)1 treatment. Clear Cell Renal Cancer Participants who have not received prior PD(L)1 treatment.

Triple negative Breast Cancer participants who have who have not received prior PD(L)1 treatment.

General inclusion criteria:

Must be 18 year old at the time of screening
Body weight > 35 kg
Male and Female participants of childbearing potential must use effective methods of contraception
Capable of giving signed informed consent
ECOG performance status of 0 to 1
A serum albumin > 30g/L
Life expectancy of > 12 weeks
At least 1 lesion, that qualifies as a RECIST 1.1 target lesion at baseline. Tumour assessment by CT scan or MRI must be performed within 28 days prior to treatment.
Participants must provide a new or previous tumour sample
Adequate organ system functions

Exclusion Criteria:

A condition that, in the opinion of the Investigator, would interfere with evaluation of the study intervention or interpretation of participant safety or study results
History of allogeneic organ transplantation.
Active or prior documented autoimmune or inflammatory disorders Uncontrolled intercurrent illness
Significant cardiac disease

History of another primary malignancy except for

Malignancy treated with curative intent and with no known active disease ≥ 5 years
non-melanoma skin cancer
Adequately treated carcinoma in situ without evidence of disease.
Participant with previous or confirmed Covid 19 diagnosis requiring significant medical intervention
Current clinical signs and symptoms consistent with COVID-19 or confirmed current infection by appropriate laboratory test within the last 4 weeks prior to screening
Any major unresolved toxicity from previous anticancer therapy
Known allergy or hypersensitivity to any of the study interventions or any of the study intervention excipients.

Prior/Concomitant Therapy

Receipt of the last dose of anticancer therapy within 5 half-lives or ≤ 21 days prior to the first dose of study
Prior treatment with potential Treg depletion therapies including agents targeting OX40 or CD357 (GITR) for 90 days prior to enrolment on study.

Participants who have received prior anti-PD-1, anti-PD-L1, or anti-CTLA-4:

Must not have experienced a toxicity that led to permanent discontinuation of prior immunotherapy.
All AEs while receiving prior immunotherapy must have completely resolved or resolved to baseline
Must not have experienced a ≥ Grade 3 imAE or a neurologic or ocular imAE of any grade while receiving prior immunotherapy.
Must not have required the use of additional immunosuppression other than corticosteroids for the management of an AE

Current or prior use of immunosuppressive medication within 14 days before the first dose of study drug. b. The following are exceptions to this criterion:

Intranasal, inhaled, topical steroids, or local steroid injections (eg, intra-articular injection).
Systemic corticosteroids at physiologic doses not to exceed 10 mg/day of prednisone or its equivalent
Steroids as premedication for hypersensitivity reactions (eg, CT scan premedication)
Any concurrent chemotherapy, investigational product, biologic, or hormonal therapy for cancer treatment
Radiotherapy treatment to more than 30% of the bone marrow or with a wide field of radiation within 4 weeks of the first dose of study intervention.
Major surgical procedure within 28 days prior to the first dose
Participants receiving anticoagulation therapy with vitamin K antagonists (eg warfarin)
Participation in another clinical study with study intervention administered in the last 30 days
Female participants who are pregnant or breastfeeding or male and female participants of reproductive potential who are not willing to employ effective birth control

Study is for people with:

Breast Cancer

Phase:

Phase 1

Estimated Enrollment:

153

Study ID:

NCT04504669

Recruitment Status:

Recruiting

Sponsor:

AstraZeneca

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There are 23 Locations for this study

See Locations Near You

Research Site
La Jolla California, 92093, United States
Research Site
Lexington Kentucky, 40536, United States
Research Site
Baltimore Maryland, 21287, United States
Research Site
Saint Louis Missouri, 63110, United States
Research Site
New Brunswick New Jersey, 08901, United States
Research Site
Huntersville North Carolina, 28078, United States
Research Site
Franklin Tennessee, 37067, United States
Research Site
Houston Texas, 77030, United States
Research Site
Arlington Virginia, 22205, United States
Research Site
Seattle Washington, 98109, United States
Research Site
Madison Wisconsin, 53792, United States
Research Site
Edmonton Alberta, T6G 1, Canada
Research Site
Toronto Ontario, M5G 2, Canada
Research Site
Creteil , 94010, France
Research Site
Rennes , 35042, France
Research Site
Toulouse Cedex 09 , 31059, France
Research Site
Villejuif Cedex , 94805, France
Research Site
Barcelona , 08035, Spain
Research Site
L'Hospitalet de Llobregat , 08907, Spain
Research Site
Madrid , 28007, Spain
Research Site
Madrid , 28027, Spain
Research Site
Madrid , 28041, Spain
Research Site
Madrid , 28050, Spain

How clear is this clinincal trial information?

Study is for people with:

Breast Cancer

Phase:

Phase 1

Estimated Enrollment:

153

Study ID:

NCT04504669

Recruitment Status:

Recruiting

Sponsor:


AstraZeneca

How clear is this clinincal trial information?

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