Breast Cancer Clinical Trial
Improving Care After Inherited Cancer Testing
Summary
The IMPACT Study seeks to refine and evaluate the effectiveness of interventions on improving guideline-adherent cancer risk management (CRM) and family communication (FC) of genetic test results. These interventions will be delivered to individuals with a documented pathogenic/likely pathogenic (P/LP) variant or variant of uncertain significance (VUS) in an inherited cancer gene.
Full Description
Through recruitment of a racially, geographically, and socioeconomically diverse sample of patients, we will achieve the following aims:
Evaluate factors associated with access to genetic risk assessment, counseling, and testing services
Conduct a randomized controlled trial to assess the effectiveness of interventions on improving guideline-adherent CRM and FC of genetic test results
Create and pilot an adaptive intervention to tailor resources to promote CRM and FC
Document and compare multiple implementation outcomes across the different interventions to maximize their effectiveness and improve reach to underserved populations
Eligibility Criteria
Inclusion Criteria:
English-speaking
Not adopted (i.e., have information about their biological relatives)
Have an email address with access to internet and a computer, tablet, or smartphone
Documented pathogenic/likely pathogenic variant or VUS in an inherited cancer gene that has CRM guidelines listed in the National Comprehensive Cancer Network (NCCN) Genetic/Familial Panel focused on Breast, Ovarian, and Pancreatic or Colorectal cancers
Are non-adherent (i.e., either undertreatment or overtreatment) to at least one of the current NCCN CRM guidelines or if currently adherent, require ongoing cancer screening
Have at least one at-risk adult, living relative who either:
has not been told about the genetic test result (if P/LP variant result) or family history of cancer (if VUS result) by the participant
has not had their own genetic testing if the participant has a pathogenic/likely pathogenic variant
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There is 1 Location for this study
Nashville Tennessee, 37212, United States More Info
Principal Investigator
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