Inspiratory Muscle Training in Obese Breast Cancer Survivors

Inclusion Criteria:

completed active treatment for a Stage 0-III breast cancer diagnosis within 6 months to 5 years of enrollment.
obese as defined by a body mass index (BMI) of 30 to 50 kg/m2 & nonobese as defined as BMI 18.5 to 24.9 kg/m2
patients who are on adjuvant endocrine therapy will be allowed to participate.
sedentary (participating in less than 90 min of moderate intensity activity per week) and have at least one limitation in activity on the 10-question RAND-36 Physical Function Subscale to ensure some exercise intolerance

Exclusion Criteria:

functional limitations that make independent exercise unsafe
current smokers
metastatic breast cancer
ongoing or active infection with recent antibiotics or steroids
heart disease precluding exercise (congestive heart failure, unstable angina pectoris, cardiac arrhythmia)
psychiatric illness/social situations that would limit compliance with study requirements
orthopedic or neuromuscular disorders or arthritis that preclude participation in exercise
unwilling or unable to follow protocol requirements
pregnant or nursing
any condition which in the investigator's opinion deems the subject an unsuitable candidate to participate in this study
presence of provokable ECG changes suggestive of heart disease, or dangerous arrhythmias or exercise induced hypertension, etc. during the cardiopulmonary exercise test
non-English speaking