Breast Cancer Clinical Trial
Integrated Cancer Repository for Cancer Research
Summary
The iCaRe2 is a multi-institutional resource created and maintained by the Fred & Pamela Buffett Cancer Center to collect and manage standardized, multi-dimensional, longitudinal data and biospecimens on consented adult cancer patients, high-risk individuals, and normal controls. The distinct characteristic of the iCaRe2 is its geographical coverage, with a significant percentage of small and rural hospitals and cancer centers. The iCaRe2 advances comprehensive studies of risk factors of cancer development and progression and enables the design of novel strategies for prevention, screening, early detection and personalized treatment of cancer. Centers with expertise in cancer epidemiology, genetics, biology, early detection, and patient care can collaborate by using the iCaRe2 as a platform for cohort and population studies.
Full Description
The integrated Cancer Repository for Cancer Research (iCaRe2 http://icare2project.org) is a unique sociotechnical resource for the collection and management of cancer and health-related data at the Fred & Pamela Buffett Cancer Center at University of Nebraska Medical Center (UNMC). The iCaRe2 is a multi-center, semantically-interoperable and easily-customizable cancer data resource which is aimed at collecting, managing, mining and sharing the comprehensive, multi-dimensional cancer-related data on cancer patients and biospecimens (such as tumor specimens, germ line DNA, serum, urine, and plasma) collected from those individuals.
The iCaRe2 provides: (i) a HIPAA compliant, secure, efficient and user-friendly mechanism for data and validation; (ii) utilization of standard vocabulary and data elements; and (iii) the ad-hoc data reporting capabilities. The iCaRe2 serves as a collaboration platform for studies (including clinical trials) performed in centers with expertise in cancer biology, pathology, epidemiology, genetics, early detection, and patient care.
The iCaRe2 has been developed as an expansion of the biocomputing framework that initially included four multi-center collaborative registries:
(i) the PCCR (Pancreatic Cancer Collaborative Registry that was established in 2001), (ii) the BCCR (Breast Cancer Collaborative Registry - established in 2006 ); (iii) the TCCR (Thyroid Cancer Collaborative Registry - established in 2006), and (iv) the GPHID (Great Plains Health Informatics Database - established in 2011 to enroll subjects who have no personal history of cancer diagnosis at the time of enrollment).
At present, this framework has been incrementally expanded to include the Thoracic Oncology Collaborative Registry (TOCR), GenitoUrinary Cancer Collaborative Registry (GUCARE), Head and Neck Cancer Collaborative Registry (HNCCR), Gastrointestinal & Abdominal Cavity Cancer Collaborative Registry (GACCaRe), Central Nervous System Tumor Collaborative Registry (CTCR), Leukemia and Myeloid Neoplasm Registry (LEMN) , Gynecological Cancer Collaborative Registry (GCCR), Sarcoma Collaborative Registry (SARCR), Melanoma Collaborative Registry (MELCR), Plasma Cell Dyscrasias Collaborative Registry (PDCR), Neuroendocrine Collaborative Registry (NETR), and Auxiliary Cancer Registry (ACR).
The iCaRe2 group elected to use a "confederation model", as opposed to a traditional registry or network model. It was felt that these latter models implied that the registry or network would assume control of an individual Center's database. The major advantages of a confederation model include the flexibility to use selected Centers for different research projects based on a Center's resources and expertise and the ability to have different strategies to address various research questions. It was also recognized that for this model to be successful, it is essential to have a standardized approach to data collection (patient information and biospecimen annotation) and reporting. A confederation would also encourage participation of any interested Center, irrespective of its size or location. A web-based registry iCaRe2 was developed and made available to any Center to participate in data collection and storage of cancer related data.
Eligibility Criteria
Inclusion Criteria.
Adult individuals (male and female) who have a personal diagnosis/history of cancer
Adult individuals who have a risk for developing cancer or suspicious clinical findings
Adult individuals with no history of cancer for normal control registry.
Able to provide consent.
19 years of age or older.
Adult individuals who are able to speak English.
Exclusion Criteria.
Individuals under age 19.
Individuals unable to provide informed consent by virtue of cognitive impairment.
Anyone who does not meet the above inclusion criteria for this project.
Non-English speaking individuals.
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There are 77 Locations for this study
Colorado Springs Colorado, 80907, United States More Info
Principal Investigator
Durango Colorado, 81301, United States More Info
Principal Investigator
Littleton Colorado, 80122, United States More Info
Principal Investigator
Longmont Colorado, 80501, United States More Info
Principal Investigator
Louisville Colorado, 80027, United States More Info
Principal Investigator
Westminster Colorado, 80228, United States More Info
Principal Investigator
Daytona Beach Florida, 32117, United States More Info
Principal Investigator
Orange City Florida, 32763, United States More Info
Principal Investigator
Palm Coast Florida, 32164, United States More Info
Principal Investigator
Aurora Illinois, 60504, United States More Info
Principal Investigator
Moline Illinois, 61265, United States
Yorkville Illinois, 60560, United States More Info
Principal Investigator
Indianapolis Indiana, 46219, United States More Info
Principal Investigator
Indianapolis Indiana, 46227, United States More Info
Principal Investigator
Indianapolis Indiana, 46256, United States More Info
Principal Investigator
Kokomo Indiana, 46902, United States More Info
Contact
Davenport Iowa, 52804, United States
Spencer Iowa, 51301, United States
Waterloo Iowa, 50702, United States More Info
Principal Investigator
Overland Park Kansas, 66213, United States More Info
Principal Investigator
New Orleans Louisiana, 70112, United States
Portland Maine, 04102, United States More Info
Principal Investigator
Westminster Maryland, 21157, United States More Info
Sub-Investigator
Holyoke Massachusetts, 01040, United States More Info
Principal Investigator
Ann Arbor Michigan, 48109, United States
Aitkin Minnesota, 56431, United States More Info
Principal Investigator
Brainerd Minnesota, 56401, United States More Info
Principal Investigator
Duluth Minnesota, 55805, United States More Info
Principal Investigator
Duluth Minnesota, 55805, United States More Info
Principal Investigator
Fergus Falls Minnesota, 56537, United States More Info
Principal Investigator
Marshall Minnesota, 56258, United States
Joplin Missouri, 64804, United States
Kansas City Missouri, 64086, United States More Info
Principal Investigator
Kansas City Missouri, 64111, United States More Info
Principal Investigator
Kansas City Missouri, 64118, United States More Info
Principal Investigator
Liberty Missouri, 64068, United States More Info
Principal Investigator
Saint Joseph Missouri, 64507, United States More Info
Principal Investigator
Bozeman Montana, 59715, United States More Info
Principal Investigator
Missoula Montana, 59802, United States More Info
Norfolk Nebraska, 68701, United States More Info
Sub-Investigator
Sub-Investigator
North Platte Nebraska, 69101, United States More Info
Principal Investigator
O'Neill Nebraska, 68763, United States
Omaha Nebraska, 68114, United States More Info
Contact
Omaha Nebraska, 68114, United States More Info
Principal Investigator
Scottsbluff Nebraska, 69361, United States
Glens Falls New York, 12801, United States More Info
Sub-Investigator
Fayetteville North Carolina, 28304, United States More Info
Contact
Minot North Dakota, 58701, United States More Info
Principal Investigator
Alliance Ohio, 44601, United States More Info
Principal Investigator
Canton Ohio, 44710, United States More Info
Principal Investigator
Pittsburgh Pennsylvania, 15323, United States
Aberdeen South Dakota, 57401, United States
Mitchell South Dakota, 57301, United States
Sioux Falls South Dakota, 57105, United States
Yankton South Dakota, 57078, United States
Yankton South Dakota, 57078, United States
Yankton South Dakota, 57078, United States
Rutland Vermont, 05701, United States More Info
Principal Investigator
Fredericksburg Virginia, 22401, United States More Info
Principal Investigator
Appleton Wisconsin, 54915, United States
Brookfield Wisconsin, 53045, United States
Franklin Wisconsin, 53132, United States
Green Bay Wisconsin, 54305, United States More Info
Principal Investigator
Mequon Wisconsin, 53097, United States
Milwaukee Wisconsin, 53211, United States
Oshkosh Wisconsin, 54904, United States
Racine Wisconsin, 53405, United States
Wauwatosa Wisconsin, 53226, United States
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