Limonene Study in Women With Breast Cancer

Inclusion Criteria:

Women who are 18 years of age or older
Women electing to undergo excision surgery for early stage breast cancer
A minimum of 2 weeks from enrollment to definitive surgery
Underwent core needle biopsy for breast cancer diagnosis
No clinical evidence of metastatic breast cancer
ECOG performance status 0-1
Participants must have normal organ and marrow function
Women of child-bearing potential must agree to use adequate contraception
Ability to understand and the willingness to sign a written informed consent document

Exclusion Criteria:

Concurrent chemotherapy or radiation therapy
Use of selective estrogen receptor modifiers or aromatase inhibitors within the past 3 months or concurrently
History of other malignancies within the past 5 years excluding non-melanoma skin cancer and cancers confined to organs with removal as only treatment
Participated in another clinical intervention trial within the past 3 months
Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
Pregnant or breast-feeding women
Use of dietary supplement that contains large amounts of d-limonene (such as Heartburn Free with ROH10 and CoQ with d-limonene) within the past 3 months