MammoSite as Sole Radiation Therapy Technique for Ductal Carcinoma In-Situ

Inclusion Criteria:

Pre-Surgery:

Unicentric pure DCIS
Lesions should have a greatest dimension of 3 cm or less as determined by pre-surgery mammography and MRI

Post-Surgery:

Negative histological margins confirmed prior to beginning radiation therapy.
Margins are positive if there is tumor at the inked margin.
Classified as low (NG1), intermediate (NG2) or high (NG3) nuclear grade DCIS, using the Philadelphia Consensus Conference Guidelines are eligible
Clinically node negative

Exclusion Criteria:

Distance from the balloon surface to the surface of the skin < 5mm as determined by CT imaging.
Distant metastases.
Invasive or in-situ lobular carcinoma (post-surgery assessment).
Nonepithelial breast malignancies such as sarcoma or lymphoma.
DCIS that is multicentric in the ipsilateral breast.
Pregnant or lactating.
Prior non-hormonal therapy for the present breast cancer, including radiation therapy and/or chemotherapy.
Collagen vascular diseases
Coexisting medical conditions with life expectancy < 2 years.
Serious psychiatric or addictive disorder
Previously treated contralateral breast carcinoma
Synchronous bilateral breast carcinoma.
Other malignancy, except non-melanoma skin cancer, < 5 years prior to participation in the study; the disease free interval from any prior carcinoma must be continuous.
Patients with diffuse disease