Breast Cancer Clinical Trial

MARGetuximab Or Trastuzumab (MARGOT)

Summary

The purpose of this study is to determine how well participants with stage II-III HER2-positive breast cancer respond to pre-operative treatment using one of two different combinations of drugs.

Drugs and Combinations used:

Paclitaxel, Pertzumab and Margetuximab (Margenza)
Paclitaxel, Pertzumab and Trastuzumab (Herceptin)

View Full Description

Full Description

This is a randomized open-label phase II trial comparing paclitaxel/margetuximab/pertuzumab (TMP) to paclitaxel/trastuzumab/pertuzumab (THP) in patients with anatomic stage II-III HER2 positive breast cancer.

The research study procedures include screening for eligibility and study treatment including laboratory evaluations, two mandatory research biopsies and follow up visits.

Participants will be randomized, which means randomly assigned, to one of two treatment arms. The treatment arms in this study and the names of the study drugs in each arm are:

Arm A: Paclitaxel, Pertzumab and Margetuximab
Arm B: Paclitaxel, Pertzumab and Trastuzumab

Participants will receive study treatment for 12 weeks prior to surgery and will be followed for 10 years after surgery. After surgery, some participants will continue to receive the study drug margetuximab for a year in total, if they respond very well to the first 12 weeks of treatment with margetuximab.

It is expected that about 171 people will take part in this research study.

This research study is a Phase II clinical trial. Phase II clinical trials test the safety and effectiveness of an investigational drug combination to learn whether the drug combination works in treating a specific disease. "Investigational" means that the drug combination is being studied.

The FDA (the U.S. Food and Drug Administration) has approved paclitaxel, trastuzumab (Herceptin), and pertuzumab as part of a pre-operative treatment option for stage II-III HER2-positive breast cancer.

The U.S. Food and Drug Administration (FDA) has approved margetuximab (Margenza) for advanced HER2-positive breast cancer.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Stage II or III (according to AJCC cancer staging manual anatomic staging table, 8th edition) histologically confirmed invasive carcinoma of the breast. A minimum tumor size of 1.5 cm (in breast mass or axillary lymph node) determined by physical exam or imaging (whichever is larger) is required. Patients with inflammatory breast carcinoma (T4d) are NOT eligible.
Centrally confirmed to have a low affinity CD16 germline genotype (FF or FV)
HER-2 positive by 2018 American Society of Clinical Oncology/College of American Pathologists criteria, as assessed by standard institutional guidelines (central testing is not required).
ER/PR determination is required. ER- and PR-assays should be performed by immunohistochemical methods according to standard institutional guidelines
Bilateral breast cancers are allowed as long as both cancers are HER2-positive (as defined in 3.1.2), or the contralateral cancer is a <1 cm, ER+ tumor.
Patients with multifocal or multicentric disease are eligible if the treating investigator hasdetermined the patient should be treated as HER2-positive.
Breast imaging should include dedicated ultrasound of the ipsilateral axilla. For subjects with a clinically positive axilla based on exam or imaging, a fine needle aspiration or core biopsy procedure will be performed to determine the presence of metastatic disease in the lymph nodes (though lymph node sampling procedure need not be resulted prior to patient's registration on trial, as long as all other eligibility are met).
Men and women (with any menopausal status) ≥18 years of age are eligible.
ECOG performance status 0 or 1

Required laboratory values demonstrating adequate organ function:

ANC ≥ 1000/mm3
Hemoglobin ≥ 9 g/dl
Platelets ≥ 100,000/mm3
Serum creatinine < 1.5 x ULN (institutional) OR calculated GFR ≥ 60mL/min
Total bilirubin ≤ 1.5 x ULN (institutional). For patients with Gilbert Syndrome, the direct bilirubin should be within the institutional normal range OR total bilirubin ≤ 2.0 mg/dL.
AST and ALT ≤ 2.5x ULN (institutional) Left ventricular ejection fraction (LVEF) ≥ 50%.
Women of childbearing potential must have a negative serum pregnancy test within 14 days of treatment start. Childbearing potential is defined as: those who have not been surgically sterilized and/or have had a menstrual period in the past 12 months
Women of childbearing potential and men with partners of childbearing potential must be willing to use one highly effective form of non-hormonal contraception or two effective forms of non-hormonal contraception by the patient and/or partner and continue its use for the duration of the study treatment and for 7 months after the last dose of study treatment.
Patients with a history of ipsilateral or contralateral DCIS or LCIS are eligible.
Patients undergoing breast conservation therapy (i.e. lumpectomy) must not have any contraindications to radiation therapy.
Non-English-speaking patients are eligible but will be exempt from patient-completed questionnaires.
Willing and able to sign informed consent.
Willing to undergo breast biopsy for research purposes.

Exclusion Criteria:

Pregnant or nursing women due to the teratogenic potential of the study drugs.
Active, unresolved infection requiring intervention
Receipt of intravenous antibiotics for infection within 7 days prior to registration.
Uncontrolled hypertension (systolic >180 mm Hg and/or diastolic >100 mm Hg) or clinically significant (i.e. active) cardiovascular disease: cerebrovascular accident/stroke or myocardial infarction within 6 months prior to first study medication, unstable angina, congestive heart failure (CHF) of New York Heart Association (NYHA) Class II or higher, or serious cardiac arrhythmia requiring medication.
Significant symptoms (Grade ≥ 2) from peripheral neuropathy.
Other concurrent serious diseases that may interfere with planned treatment, including severe pulmonary conditions/illness, uncontrolled infections, uncontrolled diabetes.
Any prior treatment for the current breast cancer, including chemotherapy, hormonal therapy, radiation, or experimental therapy.
Patients with any prior history of invasive breast cancer within the past 5 years are not eligible. Non-metastatic invasive breast cancers diagnosed more than 5 years ago and any other type of prior non-metastatic cancer is allowed.

Study is for people with:

Breast Cancer

Phase:

Phase 2

Estimated Enrollment:

171

Study ID:

NCT04425018

Recruitment Status:

Recruiting

Sponsor:

Dana-Farber Cancer Institute

Check Your Eligibility

Let’s see if you might be eligible for this study.

What is your age and gender ?

Submit

There are 17 Locations for this study

See Locations Near You

Yale Cancer Center
New Haven Connecticut, 06510, United States More Info
Maryam B. Lustberg, MD, PhD
Contact
[email protected]
Maryam B Lustberg, MD, PhD
Principal Investigator
Georgetown University Medical Center
Washington District of Columbia, 20007, United States More Info
Nellie Novielli
Contact
[email protected]
Claudine Isaacs, MD
Principal Investigator
MedStar Washington Hospital Center
Washington District of Columbia, 20010, United States More Info
Stacy Malloy
Contact
[email protected]
Claudine Isaacs, MD
Principal Investigator
The University of Chicago Medical Center
Chicago Illinois, 60637, United States
University of Chicago Comprehensive Cancer Center at Silver Cross Hospital
New Lenox Illinois, 60451, United States
University of Chicago Medical Center for Advanced Care Orland Park
Orland Park Illinois, 60462, United States
Dana Farber Cancer Institute
Boston Massachusetts, 02215, United States More Info
Adrienne Waks, MD
Contact
[email protected]ard.edu
Adrienne Waks, MD
Principal Investigator
Dana-Farber Brigham Cancer Center - Foxborough
Foxboro Massachusetts, 02035, United States More Info
Natalie Sinclair
Contact
781-624-4800
[email protected]
Natalie Sinclair, MD
Principal Investigator
Dana-Farber at Milford
Milford Massachusetts, 01757, United States More Info
Natalie Sinclair, MD
Contact
[email protected]
Natalie Sinclair, MD
Principal Investigator
Dana-Farber at South Shore Hospital
Weymouth Massachusetts, 02190, United States More Info
Thomas O'Connor, M.D.
Contact
781-337-9091
thomasp_o'[email protected]
Thomas O'Connor, MD
Principal Investigator
Montefiore Medical Center
Bronx New York, 10461, United States More Info
Jesus Anampa, MD
Contact
[email protected]
Jesus Anampa, MD
Principal Investigator
University of North Carolina at Chapel Hill
Chapel Hill North Carolina, 27599, United States More Info
Crissey Tait
Contact
[email protected]
Lisa Carey, MD
Principal Investigator
UPMC Hillman Cancer Center - Arnold Palmer at Mountain View
Greensburg Pennsylvania, 15601, United States More Info
Joshua Plassmeyer
Contact
[email protected]
Adam Brufsky, MD
Principal Investigator
UPMC Hillman Cancer Center - Arnold Palmer at Norwin
Irwin Pennsylvania, 15642, United States More Info
Joshua Plassmeyer
Contact
[email protected]
Adam Brufsky, MD
Principal Investigator
University of Pittsburgh Medical Center
Pittsburgh Pennsylvania, 15213, United States More Info
Rometa Pollard
Contact
[email protected]
Leisha Emens, MD
Principal Investigator
Baylor College of Medicine Medical Center
Houston Texas, 77030, United States More Info
Anne Pavlick
Contact
713-798-7814
[email protected]
Mothaffar Rimawi, MD
Principal Investigator
MD Anderson Cancer Center
Houston Texas, 77030, United States More Info
Pamela Lewis
Contact
[email protected]
Paula Pohlmann, MD
Principal Investigator
University of Washington Fred Hutchinson Cancer Care
Seattle Washington, 98109, United States More Info
Rachel Yung, MD
Contact
[email protected]
Rachel Yung, MD
Principal Investigator

How clear is this clinincal trial information?

Study is for people with:

Breast Cancer

Phase:

Phase 2

Estimated Enrollment:

171

Study ID:

NCT04425018

Recruitment Status:

Recruiting

Sponsor:


Dana-Farber Cancer Institute

How clear is this clinincal trial information?

×

Introducing, the Journey Bar

Use this bar to access information about the steps in your cancer journey.