Breast Cancer Clinical Trial
Molecular Imaging of Breast Cancer With Breast PET/CT
Summary
This study is a feasibility study to determine if a combined breast PET/CT scanner can image malignant functional activity while determining anatomical structure in the same clinical setting for patients with breast cancer. End-points of this study are whether women will accept the imaging position and timing, and whether functional properties of breast cancer can be imaged with this device. The secondary purpose of this study is to explore protocol parameters with a view to optimizing imaging performance whilst minimizing patient discomfort. Imaging results will be compared to histological samples to determine ground truth.
Full Description
PET is literally a molecular imaging modality. In monitoring the patient's response to a specific chemotherapeutic regime, baseline and subsequent PET/CT scans can be used to quantitatively determine the therapeutic effect of the regime, using the standard uptake value (SUV), a common metric in PET imaging. The breast PET/CT system will facilitate molecular imaging of breast cancer using a number of radiolabeled molecules, available both commercially (18-FDG) and from the research environment.
Eligibility Criteria
Inclusion Criteria:
- Normal Adult Volunteers
Female, at least 18 years of age
Ability to lie motionless for up to 20 minutes
Patient Volunteers
Female, at least 18 years of age
Diagnostic findings from prior mammography highly suggestive of invasive breast carcinoma (BI-RADS category 5)
Not pregnant or breast-feeding
Ability to lie motionless for up to 20 minutes
Exclusion Criteria:
Normal Adult Volunteers
Inability to understand the risks and benefits of the study
Patient Volunteers
Recent breast biopsy
Diagnostic findings from prior mammography highly suggestive of noninvasive ductal or lobular carcinoma
Uncontrolled diabetes
Diabetic and blood sugar level > 200 mg/dL
Positive urine pregnancy test or currently breast-feeding
Inability to understand the risks and benefits of the study
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There is 1 Location for this study
Sacramento California, 95817, United States
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