Photoacoustic Imaging in Diagnosing Changes in Tumors in Participants With Breast Cancer, Sarcoma, Skin Cancer, or Soft Tissue Malignancy and Healthy Volunteers

Inclusion Criteria:

ALL GROUPS:
No restriction on race or ethnic background.
Subject must understand the investigational nature of the study and sign an independent Ethics Committee/Institutional Review Board approved written informed consent prior to receiving any study related procedure.
HEALTHY VOLUNTEERS:
No history of antimicrobial therapy or drug treatment including anti-hypertensive, diuretic, immunosuppressive or anti-depressant drugs in the previous 6-month period.
No history of diabetes.
No history of cancer to the body site to be imaged.
BREAST, SARCOMA, SKIN CANCER, AND SUPERFICIAL MALIGNANCY PATIENTS:
Biopsy-proven aforementioned malignancy.
SURGICAL FLAP PATIENTS:
Need for plastic surgery reconstruction with a free or rotational flap.

Exclusion Criteria:

Uncontrolled illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
Unwilling or unable to follow protocol requirements or provide consent.
Any condition which in the Investigator's opinion deems the subject an unsuitable candidate to undergo imaging procedure.