Physical Activity, Fatigue, Sleep, and Inflammation

Inclusion Criteria:

Female, 30 to 70 years of age, with first diagnosis of ductal carcinoma in situ (DCIS) or Stage I or Stage II breast cancer
If chemotherapy or radiation therapy was received, the patient must be at least 4 weeks status post final primary treatment administration to allow treatment related cytokine changes to resolve. The participant may be taking longer term therapies such as aromatase inhibitors, estrogen receptor modulators, etc.
If the patient has undergone a surgical procedure, she must be at least 8 weeks post-procedure.
English speaking
Medical clearance for participation provided by primary care physician or oncologist
Postmenopausal
Average fatigue over the past week of ≥ 3 on a 1 to 10 Likert scale or sleep dysfunction ≥ 1 on a 0 to 3 Likert scale
Participating, on average, in no more than 20 minutes of physical activity on two or fewer days per week during the past six months
Willing to abstain from "as needed" medications for 7 days prior to each blood draw. "As needed" medications are defined as any medicine (prescription or over-the-counter) that is taken sporadically as needed for specific complaints rather than taken at regularly scheduled intervals (e.g., daily).

Exclusion Criteria:

Metastatic or recurrent breast cancer
Inability to ambulate without assistance
Unstable angina
New York Heart Association class II, III, or IV congestive heart failure
Uncontrolled asthma
Interstitial lung disease
Current use of steroids
Having been told by a physician to only do exercise prescribed by a physician
Dementia or organic brain syndrome
Schizophrenia or active psychosis
Connective tissue or rheumatologic disease [i.e., Systemic lupus erythematosus, rheumatoid arthritis, amyloidosis, Reiter's syndrome, psoriatic arthritis, mixed connective tissue disease, Sjögren's syndrome, progressive systemic sclerosis, CREST syndrome, polymyositis, dermatomyositis, vasculitis, polymyalgia rheumatic, temporal arteritis]
Anticipates undergoing elective surgery during the duration of the intervention which would interfere with intervention participation (e.g., breast reconstructive surgery).
Do not live or work less than 50 miles from the study site
Lack of transportation to the study site
Changes in usual medications expected during the study time period
Plan to move residence out of the local area during the 5 months of the study
Plan to travel out of the local area for vacation during the first 4 weeks of the intervention or plan to travel out of the local area for more than a week during the last 8 weeks of the intervention
Contraindication to participation in physical activity (i.e., moderate intensity walking and strength training with resistance bands)