Positron Emission Tomography (PET) Using Hormone Receptor Ligands in Breast Cancer

Inclusion Criteria:

Male and Female patients
Aged 18 or older at the time of breast cancer diagnosis
Patients with invasive breast cancer at least 1 cm in size. Patients who have had a prior surgical excision are eligible provided there is a residual of at least a 1 cm area suspected on imaging studies.
Histopathologic review at MSKCC confirming diagnosis of invasive breast cancer (ductal, lobular, or inflammatory breast cancer).
Patients who are operative candidates. Patient will have surgery to include either mastectomy or lumpectomy. Radiologic assisted excisions such as needle localization are also eligible.
Patients with bilateral breast cancer are eligible.
Patients with metastatic cancer, provided they need surgical biopsy.
Patients who are undergoing sentinel node mapping (day before or sameday mapping).
Patient must sign informed consent.

Exclusion Criteria:

Previous or concurrent malignancy (except basal and squamous skin cancer and stage 0 cervical cancer)
Patients who are pregnant or nursing
Patients unable to tolerate PET or PET/CT
Patients with known active infection, autoimmune or inflammatory disease such as sarcoidosis, and rheumatoid arthritis.
Patients with non invasive breast cancer such as DCIS.
Patients who have received prior radiation therapy to the affected breast.
Patients who have received prior chemotherapy, including neoadjuvant chemotherapy or hormonal therapy for breast cancer.
Patients living in a residential care or correctional facility.