Prolonged or Standard Infusion of Cefepime Hydrochloride in Treating Patients With Febrile Neutropenia

Inclusion Criteria:

Absolute neutrophil count < 500 cells/mm^3 or < 1000 cells/mm^3 with a predicted decrease to < 500 cells/mm^3
Temperature > 38.0 degrees Celsius
Received chemotherapy or stem-cell transplant as treatment for malignancy or myelodysplastic syndrome (MDS)
Cefepime prescribed at a dose of 2 grams IV every 8 hours

Exclusion Criteria:

Allergy to a cephalosporin antibiotic
Estimated creatinine clearance < 50 milliliters/minute
Concurrent anti-gram negative antimicrobials
Diagnostic criteria suggestive of sepsis
Circumstances which may make 3 hour infusion impractical
Solid tumor malignancy