Breast Cancer Clinical Trial
Retinoid 9cUAB30 in Producing a Biologic Effect in Patients With Early Stage Breast Cancer
This phase 1b trial studies the biologic effect of 9cUAB30 on early stage breast cancer. 9cUAB30 is a retinoid X receptor (RXR)-selective retinoid that acts in a tissue selective manner with the goal of minimizing side effects, a necessary feature of agents under development for cancer prevention.
I. Compare molecular analysis of pre- and post-treatment tissue samples of breast cancers of patients treated with 14-28 days of oral retinoid X receptor (RXR)-selective retinoid 9cUAB30 (9 cUAB30) will demonstrate significantly reduced proliferation.
I. Determine if 14-28 days of oral RXR-selective 9c-UAB30 treatment increases apoptotic index, as measured by cleaved caspase 3 assay.
II. Examine the differences in gene expression from baseline to post-exposure breast cancer samples using a custom gene panel from Nanostring Technologies.
III. To examine if the maximum concentration (Cmax) and safety of 9cUAB30 in the first 5 participants is affected by reducing the number of capsules at the 240 mg dose level.
IV. To examine the Cmax of all participants at baseline and on the day of surgery.
V. Determine if treatment with 2-4 weeks of 9cUAB30 prior to surgery will increase gene expression of type I immune cells in the tumor immune environment of all participants except the first 5.
VI. Assess the overall safety of 9cUAB30 in comparison with known retinoid toxicity.
I. Determine if treatment with 2-4 weeks of 9cUAB30 prior to surgery will increase activated type I dendritic cells in peripheral blood.
Patients receive retinoid 9cUAB30 orally (PO) once daily (QD) for 14 to 28 days. Patients then undergo tumor resection surgery.
After completion of study treatment, patients are followed up at 7 days and 4-5 weeks.
Eastern Cooperative Oncology Group (ECOG) performance status =< 1 or Karnofsky >= 70%
Invasive breast cancer diagnosed by needle core biopsy between 0.5 cm and 5 cm in size based on imaging, that is estrogen receptor positive (ER+) or estrogen receptor negative (ER-), Her2neu positive or negative OR ductal carcinoma in situ (DCIS) of the breast diagnosed by core needle biopsy and at least 1.0 cm in size based on imaging. Grade 3 ER+ DCIS will be allowed as well as ER- DCIS of any grade. For DCIS-only lesions, the imaging abnormality corresponding to the cancer must be at least 1.0 cm in size (i.e. calcifications, distortion or mass on mammogram, or mass or non-mass enhancement on magnetic resonance imaging [MRI])
White blood cells (WBC) >= 3000/mm^3
Platelets >= 100,000/mm^3
Hemoglobin > 10 g/dL
Bilirubin =< upper limit of institutional normal
Aspartate aminotransferase (AST) =< upper limit of institutional normal
Creatinine =< upper limit of institutional normal
Triglycerides =< 1.5 x upper limit of normal (ULN)
Cholesterol =< 1.5 x ULN
Participants must agree to discontinue all supplements containing vitamin A while taking study medication and for thirty days after the last dose of study medication.
Have not been treated with chemotherapy, or biological therapy in the last 5 years. We do not know if the previous treatment will have an effect on the tissues to be examined.
Have not used tamoxifen, raloxifene, or other antiestrogen compounds within 6 months of study entry. If used within 5 years of study entry, total duration of use must be less than 6 months
Have not used exogenous hormone replacement therapy or hormonal contraception in the year prior to diagnosis. The use of non-systemic estrogen (such as vaginal estrogen use) is allowed
The effects of 9cUAB30 on the developing human fetus are unknown. Since retinoids are known to be teratogenic, to avoid any complications due to unintentional pregnancies only postmenopausal women and some premenopausal women (as outlined below) will be eligible; should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her study physician immediately
Women will be considered postmenopausal if one of the following is met:
Prior bilateral oophorectomy
60 years of age or older
Age less than 60 years; amenorrheic for 12 or more months; and follicle stimulating hormone (FSH) in the postmenopausal range
Premenopausal women without childbearing potential are eligible to participate if one of the following criteria is met:
Prior fallopian tubal ligation (cut, tied, or sealed)
Prior placement of permanent intratubal contraceptive devices (e.g. Essure)
Partner with prior vasectomy and willing to use barrier method (e.g. condoms)
Participants must have the ability to understand, and the willingness to sign, a written informed consent document
Participant taking medications that might interact with 9cUAB30
Participant who has started or increased dosage of lipid-lowering agents in the last 30 days of enrollment
Participant receiving any other investigational agents within 30-days of enrollment nor during study participation with the exception of 18F-FFNP investigational imaging agent
Participant with a history of allergic reactions attributed to compounds of similar chemical or biologic composition of retinoids
Participant with an uncontrolled intercurrent illness including, but not limited to;
Ongoing or active infection,
Symptomatic congestive heart failure,
Unstable angina pectoris,
A persistent grade 3 hypertension
For grade 1, grade 2, and non-persistent grade 3 hypertension, repeat blood pressure reading after 5 minutes. If the average reading of the two measurements is grade 3 (systolic BP >=160 mm Hg or diastolic BP >=100 mm Hg) the patient is not eligible. If the average reading of the two measurements is less than or equal to grade 2, then the participant is eligible. If the average of the 2 readings is grade 1 or grade 2 hypertension, document the appropriate level hypertension on the baseline symptom form.
Psychiatric illness/social situations that will limit compliance with study requirements
Participant who is breastfeeding or planning to breastfeed for a month post last dose of study agent
Participant known to be human immunodeficiency virus (HIV)-positive, as we do not know the effects of study drug on suppression of the immune system.
Participant with a history of a second cancer diagnosis or reoccurrence < 2 years from study entry with the exception of a history of squamous or basal cell carcinoma of the skin < 2 years from study entry will not be excluded from this study. This is to eliminate the residual effects of any previous treatments for those cancers
Participant with history of ipsilateral breast radiation
Participant's core biopsy slides suggest that later re-sectioning will not contain sufficient tumor to allow for an adequate evaluation of Ki67 and caspase 3 assays, at a minimum
Check Your Eligibility
Let’s see if you might be eligible for this study.
What is your age and gender ?
There are 5 Locations for this study
Birmingham Alabama, 35233, United States
Chicago Illinois, 60611, United States
Iowa City Iowa, 52242, United States
Minneapolis Minnesota, 55455, United States
Madison Wisconsin, 53792, United States
How clear is this clinincal trial information?
Introducing, the Journey Bar
Use this bar to access information about the steps in your cancer journey.