Breast Cancer Clinical Trial

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Study Evaluating HKI-272 in Tumors

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Summary

The purpose of this study is to evaluate the safety and tolerability as well as find the maximum tolerated dose (MTD) for HKI-272. In addition, this study will examine the effects of the study drug on your tumor, and how your body uses and eliminates HKI-272.

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Eligibility Criteria

Inclusion Criteria:

Her2/neu or Her1/EGFR positive cancer
Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2
Measurable disease as defined by Response Evaluation Criteria in Solid Tumors (RECIST)

Exclusion Criteria:

Prior treatment with anthracyclines with a cumulative dose of doxorubicin or equivalent of greater than 300 mg/m^2
Patients with significant cardiac risk factors
Active central nervous system metastasis

Study is for people with:

Breast Cancer

Phase:

Phase 1

Estimated Enrollment:

73

Study ID:

NCT00146172

Recruitment Status:

Completed

Sponsor:

Puma Biotechnology, Inc.

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There are 5 Locations for this study

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H. Lee Moffitt Cancer Center & Research Institute
Tampa Florida, 33612, United States
Dana-Farber Cancer Institute
Boston Massachusetts, 02115, United States
Washington University School of Medicine
Saint Louis Missouri, 63110, United States
The Cleveland Clinic Foundation Taussig Cancer Center
Cleveland Ohio, 44195, United States
The Sarah Cannon Cancer Center
Nashville Tennessee, 37203, United States
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How clear is this clinincal trial information?

Study is for people with:

Breast Cancer

Phase:

Phase 1

Estimated Enrollment:

73

Study ID:

NCT00146172

Recruitment Status:

Completed

Sponsor:


Puma Biotechnology, Inc.

How clear is this clinincal trial information?

Clinical Trial Resources

SurvivorNet’s Guide To Clinical Trials: What Are They And Are They Right for You?
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