Breast Cancer Clinical Trial

Study of Chemotherapy-Induced Hair Changes and Alopecia, Skin Aging and Nail Changes in Women With Non-Metastatic Breast Cancer

Summary

The purpose of this study is to see how many patients develop hair, skin and nail changes due to cancer treatments. The investigators would like to study the clinical factors, genetic markers, and impact on patients' health-related quality of life to learn more about who is at greater risk. We trust that the study will improve our understanding of how cancer patients feel about their skin, hair, and nail conditions. This information will help us determine the burden on breast cancer patients and survivors. It will also help us learn how to prevent these conditions and it may improve the way we treat them and counsel patients.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Women newly diagnosed with non-metastatic breast cancer (stage 0-III, any receptor type) at the time of starting chemotherapy (dd-AC-T, CMF, Newer Combination Regimens) or endocrine therapy (tamoxifen, anastrozole, letrozole, exemestane)
Women ≥ 18 years at the time of enrollment into the study
Able to communicate in English and participate in the informed consent process
Able to comply with the follow-up visits, assessments, answering questionnaires

Exclusion Criteria:

Metastatic breast cancer
Follow-up care/visits not scheduled at MSKCC
Any current alopecia especially due to an active scalp and/or hair disorder (e.g. alopecia areata), or a pre-existing condition with sequelae (e.g. scarring alopecia)
Currently active or uncontrolled medical condition [e.g. thyroid disorder, auto-immune connective tissue disease (e.g. SLE), BMT complications (GVHD)] or medication intake (e.g. HRT), affecting scalp hair
Prior systemic treatment for any malignancy
Active secondary cancer requiring cytotoxic chemotherapy
Planned (or a history of) radiation therapy to the head
Vulnerable populations [e.g. decisionally impaired (cognitive, psychiatric), terminally ill, prisoners], or patients who, in the opinion of the investigator have a condition that precludes their ability to provide an informed consent
Men

Volunteer Inclusion Criteria:

Post menopausal women, with menopausal status defined as (per self report):
Bilateral salpingo-oophorectomy independent of age
If natural menopause, age ≥ 50 with cessation of menses for at least 12 months
Or premenopausal women with premenopausal status defined as <53 years of age with no cessation of menses
Able to communicate in English and participate in the informed consent process
Able to comply with the baseline assessments and answering questionnaires
Women >/= 18 years at the time of enrollment into the study

Study is for people with:

Breast Cancer

Estimated Enrollment:

546

Study ID:

NCT02530177

Recruitment Status:

Active, not recruiting

Sponsor:

Memorial Sloan Kettering Cancer Center

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There is 1 Location for this study

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Memorial Sloan Kettering Cancer Center
New York New York, 10021, United States

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Study is for people with:

Breast Cancer

Estimated Enrollment:

546

Study ID:

NCT02530177

Recruitment Status:

Active, not recruiting

Sponsor:


Memorial Sloan Kettering Cancer Center

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