Breast Cancer Clinical Trial

Tamoxifen Citrate in Treating Patients With Metastatic or Recurrent Breast Cancer

Summary

RATIONALE: Estrogen can cause the growth of breast cancer cells. Hormone therapy using tamoxifen citrate may fight cancer by blocking the use of estrogen by tumor cells.

PURPOSE: This phase II trial is studying how well tamoxifen citrate works in patients with metastatic or recurrent breast cancer.

View Full Description

Full Description

OBJECTIVES:

Primary

To correlate CYP2D6 score (0 vs 1-2) and progression-free survival (PFS) of patients with metastatic breast cancer treated with tamoxifen citrate.

Secondary

To correlate CYP2D6 score (0 vs 1 vs 2) and PFS of patients treated with this regimen.
To correlate CYP2D6 score (0 vs 1 + 2) and the proportion of these patients who are PFS at 6 months.
To correlate endoxifen concentration with response in patients treated with this regimen.
To correlate CYP2D6 with response in patients treated with this regimen.
To correlate the presence of candidate estrogen receptor (ESR) 1 and 2 variant alleles, UGT7, SULT1A1, and other candidate genes to PFS.

OUTLINE: This is a multicenter study.

Patients receive oral tamoxifen citrate once daily on days 1-28. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicities.

Blood, plasma, and tissue samples are collected periodically for laboratory studies.

After completion of study therapy, patients are followed up every 3-6 months for 5 years.

View Eligibility Criteria

Eligibility Criteria

DISEASE CHARACTERISTICS:

Histologically confirmed adenocarcinoma of the breast

Stage III (locally advanced), metastatic, or recurrent disease
Deemed not resectable

Estrogen-receptor and/or progesterone-receptor positive disease

Receptor status is based on most recent results
Receptor testing on metastatic disease is not required
Measurable or non-measurable disease

History of CNS metastasis allowed provided it has been treated (surgery, radiotherapy, or radiosurgery) within the past 4 weeks and does not require medications to control symptoms

No known leptomeningeal disease allowed

PATIENT CHARACTERISTICS:

ECOG performance status 0-2
Menopausal status not specified
Total bilirubin ≤ 1.5 times upper limit of normal (ULN)
ALT and AST ≤ 2.5 times ULN (≤ 5 times ULN if liver metastases present)
Not pregnant or nursing
Negative pregnancy test
Fertile patients must use effective nonhormonal contraception
No medical or psychiatric conditions that would interfere with protocol compliance, the ability to provide informed consent, assessment of response, or anticipated toxicities
More than 5 years since prior invasive malignancies except curatively treated basal cell or squamous cell carcinoma of the skin or carcinoma in situ of the cervix

PRIOR CONCURRENT THERAPY:

See Disease Characteristics

No prior investigational agents in the metastatic setting

Other prior investigational agents in any setting must have been completed at least 6 weeks prior to study registration and should be discussed with the study PI

Prior tamoxifen as adjuvant treatment is allowed as long as the patient did not have disease relapse or progression while on adjuvant tamoxifen or within 4 weeks of last dose

Prior tamoxifen for advanced disease is not allowed

No prior chemotherapy or trastuzumab (Herceptin) for metastatic disease

Prior chemotherapy, trastuzumab, or bevacizumab in the adjuvant setting allowed provided it has been completed ≥ 4 weeks before study therapy

Patients must not have had more than 2 lines of non-hormonal treatment in the locally advanced or metastatic setting, including trastuzumab (Herceptin), bevacizumab, or other biologics

Treatment in the advanced setting must have been completed at least 2 weeks prior to study initiation
Prior aromatase inhibitors (e.g., anastrozole, letrozole, exemestane, aminoglutethamide) are allowed in the adjuvant or metastatic setting

At least 2 weeks since prior and no concurrent medications that are strong to moderate inhibitors of CYP2D6 and may alter tamoxifen citrate metabolism including, but not limited to, any of the following:

Paroxetine (Paxil)
Fluoxetine (Prozac)
Bupropion (Wellbutrin)
Quinidine (Cardioquin)

Patients may not initiate bisphosphonate therapy while receiving treatment on this study

Patients who have begun receiving bisphosphonate therapy prior to registration may continue at the same intervals used prior to study registration

Concurrent radiotherapy to painful sites of bone disease or areas of impending fractures allowed provided the following criteria are met:

Radiotherapy was initiated before study entry
Sites of measurable or non-measurable disease are outside the radiotherapy port
Recovered from prior radiotherapy
No other concurrent hormonal therapy
No concurrent chemotherapy

Study is for people with:

Breast Cancer

Phase:

Phase 2

Estimated Enrollment:

240

Study ID:

NCT01124695

Recruitment Status:

Active, not recruiting

Sponsor:

Eastern Cooperative Oncology Group

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There are 255 Locations for this study

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UAB Comprehensive Cancer Center
Birmingham Alabama, 35294, United States
University of South Alabama Mitchell Cancer Institute
Mobile Alabama, 36604, United States
Hembree Mercy Cancer Center at St. Edward Mercy Medical Center
Fort Smith Arkansas, 72903, United States
Tibotec Therapeutics - Division of Ortho Biotech Products, LP
Marysville California, 95901, United States
Mercy Cancer Center at Mercy Medical Center
Merced California, 95340, United States
Camino Medical Group - Treatment Center
Mountain View California, 94040, United States
St. Joseph Hospital Regional Cancer Center - Orange
Orange California, 92868, United States
Palo Alto Medical Foundation
Palo Alto California, 94301, United States
Valley Medical Oncology Consultants - Pleasanton
Pleasanton California, 94588, United States
University of California Davis Cancer Center
Sacramento California, 95817, United States
Tahoe Forest Cancer Center
Truckee California, 96161, United States
Aurora Presbyterian Hospital
Aurora Colorado, 80012, United States
Boulder Community Hospital
Boulder Colorado, 80301, United States
Penrose Cancer Center at Penrose Hospital
Colorado Springs Colorado, 80933, United States
St. Anthony Central Hospital
Denver Colorado, 80204, United States
Porter Adventist Hospital
Denver Colorado, 80210, United States
Presbyterian - St. Luke's Medical Center
Denver Colorado, 80218, United States
St. Joseph Hospital
Denver Colorado, 80218, United States
Rose Medical Center
Denver Colorado, 80220, United States
CCOP - Colorado Cancer Research Program
Denver Colorado, 80222, United States
Swedish Medical Center
Englewood Colorado, 80110, United States
St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center
Grand Junction Colorado, 81502, United States
North Colorado Medical Center
Greeley Colorado, 80631, United States
Littleton Adventist Hospital
Littleton Colorado, 80122, United States
Sky Ridge Medical Center
Lone Tree Colorado, 80124, United States
Hope Cancer Care Center at Longmont United Hospital
Longmont Colorado, 80501, United States
McKee Medical Center
Loveland Colorado, 80539, United States
Parker Adventist Hospital
Parker Colorado, 80138, United States
St. Mary - Corwin Regional Medical Center
Pueblo Colorado, 81004, United States
North Suburban Medical Center
Thornton Colorado, 80229, United States
Exempla Lutheran Medical Center
Wheat Ridge Colorado, 80033, United States
Middlesex Hospital Cancer Center
Middletown Connecticut, 06457, United States
Yale Cancer Center
New Haven Connecticut, 06520, United States
Tunnell Cancer Center at Beebe Medical Center
Lewes Delaware, 19958, United States
CCOP - Christiana Care Health Services
Newark Delaware, 19713, United States
Lombardi Comprehensive Cancer Center at Georgetown University Medical Center
Washington District of Columbia, 20007, United States
Washington Cancer Institute at Washington Hospital Center
Washington District of Columbia, 20010, United States
Broward General Medical Center Cancer Center
Fort Lauderdale Florida, 33316, United States
Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler
Savannah Georgia, 31405, United States
Kapiolani Medical Center at Pali Momi
'Aiea Hawaii, 96701, United States
Cancer Research Center of Hawaii
Honolulu Hawaii, 96813, United States
OnCare Hawaii, Incorporated - Lusitana
Honolulu Hawaii, 96813, United States
Queen's Cancer Institute at Queen's Medical Center
Honolulu Hawaii, 96813, United States
Straub Clinic and Hospital, Incorporated
Honolulu Hawaii, 96813, United States
Hawaii Medical Center - East
Honolulu Hawaii, 96817, United States
OnCare Hawaii, Incorporated - Kuakini
Honolulu Hawaii, 96817, United States
Kapiolani Medical Center for Women and Children
Honolulu Hawaii, 96826, United States
Kauai Medical Clinic
Lihue Hawaii, 96766, United States
Maui Memorial Medical Center
Wailuku Hawaii, 96793, United States
Pacific Cancer Institute - Maui
Wailuku Hawaii, 96793, United States
Louis A. Weiss Memorial Hospital
Chicago Illinois, 60640, United States
Decatur Memorial Hospital Cancer Care Institute
Decatur Illinois, 62526, United States
Elmhurst Memorial Hospital
Elmhurst Illinois, 60126, United States
La Grange Memorial Hospital
La Grange Illinois, 60525, United States
West Suburban Center for Cancer Care
River Forest Illinois, 60305, United States
St. Francis Hospital and Health Centers - Beech Grove Campus
Beech Grove Indiana, 46107, United States
Elkhart Clinic, LLC
Elkhart Indiana, 46514, United States
Michiana Hematology-Oncology, PC - Elkhart
Elkhart Indiana, 46514, United States
Elkhart General Hospital
Elkhart Indiana, 46515, United States
William N. Wishard Memorial Hospital
Indianapolis Indiana, 46202, United States
Howard Community Hospital
Kokomo Indiana, 46904, United States
Center for Cancer Therapy at LaPorte Hospital and Health Services
La Porte Indiana, 46350, United States
Michiana Hematology-Oncology, PC - South Bend
Mishawaka Indiana, 46545, United States
Saint Joseph Regional Medical Center
Mishawaka Indiana, 46545, United States
Cancer Center at Ball Memorial Hospital
Muncie Indiana, 47303, United States
Michiana Hematology Oncology PC - Plymouth
Plymouth Indiana, 46563, United States
Reid Hospital & Health Care Services
Richmond Indiana, 47374, United States
CCOP - Northern Indiana CR Consortium
South Bend Indiana, 46601, United States
Memorial Hospital of South Bend
South Bend Indiana, 46601, United States
Michiana Hematology Oncology PC - La Porte
Westville Indiana, 46391, United States
McFarland Clinic, PC
Ames Iowa, 50010, United States
Medical Oncology and Hematology Associates - West Des Moines
Clive Iowa, 50325, United States
Mercy Cancer Center - West Lakes
Clive Iowa, 50325, United States
CCOP - Iowa Oncology Research Association
Des Moines Iowa, 50309, United States
John Stoddard Cancer Center at Iowa Methodist Medical Center
Des Moines Iowa, 50309, United States
Medical Oncology and Hematology Associates at John Stoddard Cancer Center
Des Moines Iowa, 50309, United States
Medical Oncology and Hematology Associates at Mercy Cancer Center
Des Moines Iowa, 50314, United States
Mercy Cancer Center at Mercy Medical Center - Des Moines
Des Moines Iowa, 50314, United States
John Stoddard Cancer Center at Iowa Lutheran Hospital
Des Moines Iowa, 50316, United States
Siouxland Hematology-Oncology Associates, LLP
Sioux City Iowa, 51101, United States
Mercy Medical Center - Sioux City
Sioux City Iowa, 51102, United States
St. Luke's Regional Medical Center
Sioux City Iowa, 51104, United States
Methodist West Hospital
West Des Moines Iowa, 50266, United States
Cancer Center of Kansas, PA - Chanute
Chanute Kansas, 66720, United States
Cancer Center of Kansas, PA - Dodge City
Dodge City Kansas, 67801, United States
Cancer Center of Kansas, PA - El Dorado
El Dorado Kansas, 67042, United States
Cancer Center of Kansas - Fort Scott
Fort Scott Kansas, 66701, United States
Cancer Center of Kansas-Independence
Independence Kansas, 67301, United States
Cancer Center of Kansas, PA - Kingman
Kingman Kansas, 67068, United States
Lawrence Memorial Hospital
Lawrence Kansas, 66044, United States
Cancer Center of Kansas, PA - Liberal
Liberal Kansas, 67901, United States
Cancer Center of Kansas, PA - McPherson
McPherson Kansas, 67460, United States
Cancer Center of Kansas, PA - Newton
Newton Kansas, 67114, United States
Cancer Center of Kansas, PA - Parsons
Parsons Kansas, 67357, United States
Cancer Center of Kansas, PA - Pratt
Pratt Kansas, 67124, United States
Cancer Center of Kansas, PA - Salina
Salina Kansas, 67401, United States
Cancer Center of Kansas, PA - Wellington
Wellington Kansas, 67152, United States
Associates in Womens Health, PA - North Review
Wichita Kansas, 67208, United States
Cancer Center of Kansas, PA - Medical Arts Tower
Wichita Kansas, 67208, United States
Cancer Center of Kansas, PA - Wichita
Wichita Kansas, 67214, United States
CCOP - Wichita
Wichita Kansas, 67214, United States
Via Christi Cancer Center at Via Christi Regional Medical Center
Wichita Kansas, 67214, United States
Cancer Center of Kansas, PA - Winfield
Winfield Kansas, 67156, United States
Greenebaum Cancer Center at University of Maryland Medical Center
Baltimore Maryland, 21201, United States
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore Maryland, 21231, United States
Union Hospital of Cecil County
Elkton Maryland, 21921, United States
Hickman Cancer Center at Bixby Medical Center
Adrian Michigan, 49221, United States
University of Michigan Comprehensive Cancer Center
Ann Arbor Michigan, 48109, United States
Barbara Ann Karmanos Cancer Institute
Detroit Michigan, 48201, United States
Josephine Ford Cancer Center at Henry Ford Hospital
Detroit Michigan, 48202, United States
Green Bay Oncology, Limited - Escanaba
Escanaba Michigan, 49431, United States
Dickinson County Healthcare System
Iron Mountain Michigan, 49801, United States
Borgess Medical Center
Kalamazoo Michigan, 49001, United States
West Michigan Cancer Center
Kalamazoo Michigan, 49007, United States
Bronson Methodist Hospital
Kalamazoo Michigan, 49007, United States
Community Cancer Center of Monroe
Monroe Michigan, 48162, United States
Mercy Memorial Hospital - Monroe
Monroe Michigan, 48162, United States
Lakeland Regional Cancer Care Center - St. Joseph
Saint Joseph Michigan, 49085, United States
Lakeside Cancer Specialists, PLLC
Saint Joseph Michigan, 49085, United States
MeritCare Bemidji
Bemidji Minnesota, 56601, United States
St. Joseph's Medical Center
Brainerd Minnesota, 56401, United States
Fairview Ridges Hospital
Burnsville Minnesota, 55337, United States
Mercy and Unity Cancer Center at Mercy Hospital
Coon Rapids Minnesota, 55433, United States
Duluth Clinic Cancer Center - Duluth
Duluth Minnesota, 55805, United States
CCOP - Duluth
Duluth Minnesota, 55805, United States
Miller - Dwan Medical Center
Duluth Minnesota, 55805, United States
Fairview Southdale Hospital
Edina Minnesota, 55435, United States
Mercy and Unity Cancer Center at Unity Hospital
Fridley Minnesota, 55432, United States
Hutchinson Area Health Care
Hutchinson Minnesota, 55350, United States
Immanuel St. Joseph's
Mankato Minnesota, 56002, United States
HealthEast Cancer Care at St. John's Hospital
Maplewood Minnesota, 55109, United States
Minnesota Oncology - Maplewood
Maplewood Minnesota, 55109, United States
Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
Minneapolis Minnesota, 55407, United States
Hennepin County Medical Center - Minneapolis
Minneapolis Minnesota, 55415, United States
New Ulm Medical Center
New Ulm Minnesota, 56073, United States
Humphrey Cancer Center at North Memorial Outpatient Center
Robbinsdale Minnesota, 55422, United States
Mayo Clinic Cancer Center
Rochester Minnesota, 55905, United States
CCOP - Metro-Minnesota
Saint Louis Park Minnesota, 55416, United States
Park Nicollet Cancer Center
Saint Louis Park Minnesota, 55416, United States
Regions Hospital Cancer Care Center
Saint Paul Minnesota, 55101, United States
United Hospital
Saint Paul Minnesota, 55102, United States
St. Francis Cancer Center at St. Francis Medical Center
Shakopee Minnesota, 55379, United States
Lakeview Hospital
Stillwater Minnesota, 55082, United States
Ridgeview Medical Center
Waconia Minnesota, 55387, United States
Willmar Cancer Center at Rice Memorial Hospital
Willmar Minnesota, 56201, United States
Minnesota Oncology - Woodbury
Woodbury Minnesota, 55125, United States
University of Mississippi Cancer Clinic
Jackson Mississippi, 39216, United States
Central Care Cancer Center at Carrie J. Babb Cancer Center
Bolivar Missouri, 65613, United States
Skaggs Cancer Center at Skaggs Regional Medical Center
Branson Missouri, 65616, United States
Southeast Cancer Center
Cape Girardeau Missouri, 63703, United States
Goldschmidt Cancer Center
Jefferson City Missouri, 65109, United States
Mercy Clinic Cancer and Hematology - Rolla
Rolla Missouri, 65401, United States
Missouri Baptist Cancer Center
Saint Louis Missouri, 63131, United States
CCOP - Cancer Research for the Ozarks
Springfield Missouri, 65802, United States
St. John's Regional Health Center
Springfield Missouri, 65804, United States
Hulston Cancer Center at Cox Medical Center South
Springfield Missouri, 65807, United States
CCOP - Montana Cancer Consortium
Billings Montana, 59101, United States
St. Vincent Healthcare Cancer Care Services
Billings Montana, 59101, United States
Hematology-Oncology Centers of the Northern Rockies - Billings
Billings Montana, 59102, United States
Billings Clinic - Downtown
Billings Montana, 59107, United States
Bozeman Deaconess Cancer Center
Bozeman Montana, 59715, United States
St. James Healthcare Cancer Care
Butte Montana, 59701, United States
Big Sky Oncology
Great Falls Montana, 59405, United States
Sletten Cancer Institute at Benefis Healthcare
Great Falls Montana, 59405, United States
St. Peter's Hospital
Helena Montana, 59601, United States
Kalispell Medical Oncology at KRMC
Kalispell Montana, 59901, United States
Kalispell Regional Medical Center
Kalispell Montana, 59901, United States
Montana Cancer Specialists at Montana Cancer Center
Missoula Montana, 59807, United States
Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
Missoula Montana, 59807, United States
Good Samaritan Cancer Center at Good Samaritan Hospital
Kearney Nebraska, 68848, United States
Cancer Resource Center - Lincoln
Lincoln Nebraska, 68510, United States
CCOP - Missouri Valley Cancer Consortium
Omaha Nebraska, 68106, United States
Immanuel Medical Center
Omaha Nebraska, 68122, United States
Alegant Health Cancer Center at Bergan Mercy Medical Center
Omaha Nebraska, 68124, United States
Lakeside Hospital
Omaha Nebraska, 68130, United States
Creighton University Medical Center
Omaha Nebraska, 68131, United States
CCOP - Nevada Cancer Research Foundation
Las Vegas Nevada, 89106, United States
Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton
Marlton New Jersey, 08053, United States
St. Joseph's Hospital and Medical Center
Paterson New Jersey, 07503, United States
Somerset Medical Center
Somerville New Jersey, 08876, United States
J. Phillip Citta Regional Cancer Center at Community Medical Center
Toms River New Jersey, 08755, United States
Cancer Institute of New Jersey at Cooper - Voorhees
Voorhees New Jersey, 08043, United States
Fox Chase Virtua Health Cancer Program at Virtua West Jersey
Voorhees New Jersey, 08043, United States
Lovelace Medical Center - Downtown
Albuquerque New Mexico, 87102, United States
University of New Mexico Cancer Center
Albuquerque New Mexico, 87131, United States
University of New Mexico Cancer Center - South
Las Cruces New Mexico, 88011, United States
Albert Einstein Cancer Center at Albert Einstein College of Medicine
Bronx New York, 10461, United States
Charles R. Wood Cancer Center at Glens Falls Hospital
Glens Falls New York, 12801, United States
Beth Israel Medical Center - Petrie Division
New York New York, 10003, United States
St. Luke's - Roosevelt Hospital Center - St.Luke's Division
New York New York, 10025, United States
Wayne Memorial Hospital, Incorporated
Goldsboro North Carolina, 27534, United States
Kinston Medical Specialists
Kinston North Carolina, 28501, United States
Medcenter One Hospital Cancer Care Center
Bismarck North Dakota, 58501, United States
Mid Dakota Clinic, PC
Bismarck North Dakota, 58501, United States
St. Alexius Medical Center Cancer Center
Bismarck North Dakota, 58502, United States
MeritCare Broadway
Fargo North Dakota, 58102, United States
CCOP - MeritCare Hospital
Fargo North Dakota, 58122, United States
Roger Maris Cancer Center at MeritCare Hospital
Fargo North Dakota, 58122, United States
McDowell Cancer Center at Akron General Medical Center
Akron Ohio, 44307, United States
Cleveland Clinic Beachwood Family Health and Surgery Center
Beachwood Ohio, 44122, United States
Wood County Oncology Center
Bowling Green Ohio, 43402, United States
Aultman Cancer Center at Aultman Hospital
Canton Ohio, 44710, United States
Case Comprehensive Cancer Center
Cleveland Ohio, 44106, United States
Cleveland Clinic Cancer Center at Fairview Hospital
Cleveland Ohio, 44111, United States
Cleveland Clinic Taussig Cancer Center
Cleveland Ohio, 44195, United States
Grandview Hospital
Dayton Ohio, 45405, United States
Good Samaritan Hospital
Dayton Ohio, 45406, United States
David L. Rike Cancer Center at Miami Valley Hospital
Dayton Ohio, 45409, United States
Samaritan North Cancer Care Center
Dayton Ohio, 45415, United States
CCOP - Dayton
Dayton Ohio, 45420, United States
Community Cancer Center
Elyria Ohio, 44035, United States
Hematology Oncology Center
Elyria Ohio, 44035, United States
Blanchard Valley Medical Associates
Findlay Ohio, 45840, United States
Middletown Regional Hospital
Franklin Ohio, 45005, United States
Wayne Hospital
Greenville Ohio, 45331, United States
Cleveland Clinic Cancer Center
Independence Ohio, 44131, United States
Charles F. Kettering Memorial Hospital
Kettering Ohio, 45429, United States
Lima Memorial Hospital
Lima Ohio, 45804, United States
Northwest Ohio Oncology Center
Maumee Ohio, 43537, United States
Hillcrest Cancer Center at Hillcrest Hospital
Mayfield Heights Ohio, 44124, United States
St. Charles Mercy Hospital
Oregon Ohio, 43616, United States
Toledo Clinic - Oregon
Oregon Ohio, 43616, United States
Parma Community General Hospital
Parma Ohio, 44129, United States
North Coast Cancer Care, Incorporated
Sandusky Ohio, 44870, United States
Cleveland Clinic Foundation - Strongsville
Strongsville Ohio, 44136, United States
Flower Hospital Cancer Center
Sylvania Ohio, 43560, United States
Mercy Hospital of Tiffin
Tiffin Ohio, 44883, United States
Toledo Hospital
Toledo Ohio, 43606, United States
St. Vincent Mercy Medical Center
Toledo Ohio, 43608, United States
Medical University of Ohio Cancer Center
Toledo Ohio, 43614, United States
CCOP - Toledo Community Hospital
Toledo Ohio, 43617, United States
St. Anne Mercy Hospital
Toledo Ohio, 43623, United States
Toledo Clinic, Incorporated - Main Clinic
Toledo Ohio, 43623, United States
UVMC Cancer Care Center at Upper Valley Medical Center
Troy Ohio, 45373, United States
Fulton County Health Center
Wauseon Ohio, 43567, United States
Cleveland Clinic - Wooster
Wooster Ohio, 44691, United States
United States Air Force Medical Center - Wright-Patterson
Wright-Patterson Air Force Base Ohio, 45433, United States
Ruth G. McMillan Cancer Center at Greene Memorial Hospital
Xenia Ohio, 45385, United States
Cancer Care Associates - Norman
Norman Oklahoma, 73071, United States
Cancer Care Associates - Mercy Campus
Oklahoma City Oklahoma, 73120, United States
Doylestown Hospital Cancer Center
Doylestown Pennsylvania, 18901, United States
Penn State Hershey Cancer Institute at Milton S. Hershey Medical Center
Hershey Pennsylvania, 17033, United States
Lancaster General Hospital
Lancaster Pennsylvania, 17604, United States
St. Mary Regional Cancer Center
Langhorne Pennsylvania, 19047, United States
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
Philadelphia Pennsylvania, 19107, United States
Pottstown Memorial Regional Cancer Center
Pottstown Pennsylvania, 19464, United States
Sanford Cancer Center at Sanford USD Medical Center
Sioux Falls South Dakota, 57117, United States
Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas
Dallas Texas, 75390, United States
Fredericksburg Oncology, Incorporated
Fredericksburg Virginia, 22401, United States
Island Hospital Cancer Care Center at Island Hospital
Anacortes Washington, 98221, United States
St. Joseph Cancer Center
Bellingham Washington, 98225, United States
Olympic Hematology and Oncology
Bremerton Washington, 98310, United States
Highline Medical Center Cancer Center
Burien Washington, 98166, United States
Swedish Medical Center - Issaquah Campus
Issaquah Washington, 98029, United States
Columbia Basin Hematology
Kennewick Washington, 99336, United States
Skagit Valley Hospital Cancer Care Center
Mount Vernon Washington, 98274, United States
Harrison Poulsbo Hematology and Onocology
Poulsbo Washington, 98370, United States
Harborview Medical Center
Seattle Washington, 98104, United States
Minor and James Medical, PLLC
Seattle Washington, 98104, United States
Fred Hutchinson Cancer Research Center
Seattle Washington, 98109, United States
Group Health Central Hospital
Seattle Washington, 98112, United States
Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
Seattle Washington, 98122, United States
Polyclinic First Hill
Seattle Washington, 98122, United States
University Cancer Center at University of Washington Medical Center
Seattle Washington, 98195, United States
North Puget Oncology at United General Hospital
Sedro-Woolley Washington, 98284, United States
Cancer Care Northwest - Spokane South
Spokane Washington, 99202, United States
Evergreen Hematology and Oncology, PS
Spokane Washington, 99218, United States
Wenatchee Valley Medical Center
Wenatchee Washington, 98801, United States
West Virginia University Health Sciences Center - Charleston
Charleston West Virginia, 25304, United States
Langlade Memorial Hospital
Antigo Wisconsin, 54409, United States
Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center
Green Bay Wisconsin, 54301, United States
Green Bay Oncology, Limited at St. Mary's Hospital
Green Bay Wisconsin, 54303, United States
St. Mary's Hospital Medical Center - Green Bay
Green Bay Wisconsin, 54303, United States
St. Vincent Hospital Regional Cancer Center
Green Bay Wisconsin, 54307, United States
Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center
Green Bay Wisconsin, 54311, United States
Gundersen Lutheran Center for Cancer and Blood
La Crosse Wisconsin, 54601, United States
Holy Family Memorial Medical Center Cancer Care Center
Manitowoc Wisconsin, 54221, United States
Bay Area Cancer Care Center at Bay Area Medical Center
Marinette Wisconsin, 54143, United States
Vince Lombardi Cancer Clinic - Marinette
Marinette Wisconsin, 54143, United States
D.N. Greenwald Center
Mukwonago Wisconsin, 53149, United States
Regional Cancer Center at Oconomowoc Memorial Hospital
Oconomowoc Wisconsin, 53066, United States
Green Bay Oncology, Limited - Oconto Falls
Oconto Falls Wisconsin, 54154, United States
Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh Wisconsin, 54904, United States
St. Nicholas Hospital
Sheboygan Wisconsin, 53081, United States
Vince Lombardi Cancer Clinic - Sheboygan
Sheboygan Wisconsin, 53081, United States
Green Bay Oncology, Limited - Sturgeon Bay
Sturgeon Bay Wisconsin, 54235, United States
Aurora Medical Center
Summit Wisconsin, 53066, United States
Vince Lombardi Cancer Clinic - Two Rivers
Two Rivers Wisconsin, 54241, United States
Waukesha Memorial Hospital Regional Cancer Center
Waukesha Wisconsin, 53188, United States
University of Wisconcin Cancer Center at Aspirus Wausau Hospital
Wausau Wisconsin, 54401, United States
Riverview UW Cancer Center at Riverview Hospital
Wisconsin Rapids Wisconsin, 54494, United States
Rocky Mountain Oncology
Casper Wyoming, 82609, United States
British Columbia Cancer Agency - Vancouver Cancer Centre
Vancouver British Columbia, V5Z 4, Canada
Instituto Nacional de Enfermedades Neoplasicas
Lima , Lima , Peru

How clear is this clinincal trial information?

Study is for people with:

Breast Cancer

Phase:

Phase 2

Estimated Enrollment:

240

Study ID:

NCT01124695

Recruitment Status:

Active, not recruiting

Sponsor:


Eastern Cooperative Oncology Group

How clear is this clinincal trial information?

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