Breast Cancer Clinical Trial
TOBI to Monitor Response to Neoadjuvant Therapy in Breast Cancer
Summary
The purpose of this research study is to see if Near-Infrared Tomographic Optical Breast Imaging (TOBI) scans can help monitor breast tumor response during treatment for breast cancer. The images created by the TOBI scan show changes in blood blow and oxygen levels in breast tissue.
Full Description
Participants will have a TOBI scan prior to starting their cancer treatment and again on day 8 after their first treatment. Participants will also be asked if they would volunteer to undergoing one or more additional TOBI scans on days 2-7 after they begin cancer treatment. These additional scans are optional. Participants will also have a scan on the first day of each treatment cycle.
TOBI scans will be performed at the Gillette Center for Breast Cancer at the Massachusetts General Hospital.
For the scan, each breast is placed between 2 plastic plates in order to spread the tissue apart, similar to the procedure for a mammogram. The TOBI scanner is attached to these plates. We will apply mild pressure to compress the breast and the breast will be scanned using light waves. Each scan will take about 3 minutes.
Eligibility Criteria
Inclusion Criteria:
Adult female patients presenting to the MGH Cancer Center Gillette Center for breast cancer neoadjuvant therapy
Subject who have had or will have a clinically indicated pre-treatment breast MRI
Exclusion Criteria:
Younger than 18 years of age
Open wounds on breast
Breast implants, because they may interfere with readings
Subjects who will be receiving preoperative therapy for <28 days
Breast surgery or biopsy < 10 days prior to optical imaging scan
Medical or psychiatric or other medical condition that the principal investigator believes may result in inability to complete the study
Bilateral breast cancers or a history of contralateral breast cancer
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There is 1 Location for this study
Boston Massachusetts, 02114, United States
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