Trial Comparing the Effects of Linear Versus Nonlinear Aerobic Training in Women With Operable Breast Cancer

Inclusion Criteria:

Aged 45-80 years
Female
Has been diagnosed with early-stage breast cancer
Post-menopausal, defined as :
Age ≥ 45 with no menses for at least 2 years
Chemically induced menopause through ovarian suppression, as determined by the primary oncologist

An interval of at least one year, but no more than five years, following the full completion of primary therapy for malignant disease. Primary therapy is defined as:

Surgery plus radiation
Surgery plus chemotherapy
Surgery plus trastuzumab
Surgery plus hormone therapy Note: For patients who receive hormone therapy following surgery, the definition of one-year post-completion of therapy is defined by the surgery date. Patients who are currently receiving hormone therapy are eligible for enrollment.
Weight of < 205 kgs
ECOG status of 0 or 1
Life expectancy ≥ 6 months
Performing less than 150 minutes of structured moderate-intensity or strenuous intensity exercise per week.
Exercise intolerance defined by a VO2peak below that predicted for sedentary age and sex-matched individuals as defined in Appendix H.
Willing to be randomized to one of the study arms
Able to complete an acceptable baseline CPET, in the absence of high risk ECG findings or other inappropriate response to exercise as determined by the investigator.

Able to achieve an acceptable peak baseline CPET, as defined by any of the following criteria:

Achieving a plateau in oxygen consumption, concurrent with an increase in power output;
A respiratory exchange ratio ≥ 1.10;
Attainment of maximal predicted heart rate (HRmax) (i.e., within 10 bpm of age-predicted HRmax [HRmax = 220-Age[years]);
Volitional exhaustion, as measured by a rating of perceived exertion (RPE) ≥ 18 on the BORG scale.

Exclusion Criteria:

Any of the following absolute contraindications to cardiopulmonary exercise testing:

Acute myocardial infarction within 3-5 days of any planned study procedures;
Unstable angina;
Uncontrolled arrhythmia causing symptoms or hemodynamic compromise;
Recurrent syncope;
Active endocarditis;
Acute myocarditis or pericarditis;
Symptomatic severe aortic stenosis;
Uncontrolled heart failure;
Acute pulmonary embolus or pulmonary infarction within 3 months of any planned study procedures
Thrombosis of lower extremities;
Suspected dissecting aneurysm;
Uncontrolled asthma;
Pulmonary edema;
Respiratory failure;
Acute non-cardiopulmonary disorders that may affect exercise performance or be aggravated by exercise (i.e., infection, renal failure, thyrotoxicosis);
Presence of any other concurrent, actively treated malignancy
History of any other malignancy treated within the past 3 years (other than non-melanoma skin cancer)
Presence of metastatic disease
Room air desaturation at rest ≤ 85%
Mental impairment leading to inability to cooperate
Any other condition or intercurrent illness that, in the opinion of the investigator, makes the participant a poor candidate for the trial