Breast Cancer Clinical Trial
Trial Evaluating Dovitinib Combined With Fulvestrant, in Postmenopausal Patients With HER2- and HR+ Breast Cancer
Summary
This trial is designed to enroll postmenopausal patients with locally advanced or metastatic, HER2- and HR+ breast cancer not amenable to curative treatment by surgery or radiotherapy, and whose disease has progressed on or after prior endocrine therapy.
Patients must undergo molecular pre-screening prior to entry.
View Eligibility Criteria
Eligibility Criteria
Inclusion Criteria:
Postmenopausal women with HER2-, HR+ locally advanced or metastatic breast cancer
Progression on or after endocrine treatment
Measureable disease as per RECIST
ECOG 0, 1 or 2
Exclusion Criteria:
Evidence of CNS or leptomeningeal metastases
Previous treatment with fulvestrant
Previous chemotherapy for locally advanced or metastatic breast cancer
Cirrhosis or chronic active/persistent hepatitis
Other protocol-defined inclusion/exclusion criteria may apply
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There are 67 Locations for this study
See Locations Near You
Ironwood Cancer and Research Centers SC
Chandler Arizona, 85224, United States
Chandler Arizona, 85224, United States
Highlands Oncology Group Dept of Highlands Oncology Grp
Fayetteville Arkansas, 72703, United States
Fayetteville Arkansas, 72703, United States
City of Hope National Medical Center COH 3
Duarte California, 91010, United States
Duarte California, 91010, United States
University of California San Diego - Moores Cancer Center Moores UCSD Cancer Ctr. SC-1
La Jolla California, 92093, United States
La Jolla California, 92093, United States
Cedars Sinai Medical Center Samuel Oschin Cancer Center
Los Angeles California, 90048, United States
Los Angeles California, 90048, United States
H. Lee Moffitt Cancer Center & Research Institute H. Lee Moffitt SC
Tampa Florida, 33612, United States
Tampa Florida, 33612, United States
Oncology Specialists, SC Lutheran General Advanced Care
Park Ridge Illinois, 60068, United States
Park Ridge Illinois, 60068, United States
Indiana University Health Goshen Center for Cancer SC
Goshen Indiana, 46526, United States
Goshen Indiana, 46526, United States
Nebraska Methodist Hospital Estabrook Cancer Center
Omaha Nebraska, 68114, United States
Omaha Nebraska, 68114, United States
Saint Barnabas Medical Center CancerCenter of Saint Barnabas
Livingston New Jersey, 07039, United States
Livingston New Jersey, 07039, United States
ProHealth Care
Lake Success New York, 11042, United States
Lake Success New York, 11042, United States
New York Oncology Hematology, P.C. Dept. of New York Oncology. PC
Troy New York, 12180, United States
Troy New York, 12180, United States
Duke University Medical Center Duke (SC)
Durham North Carolina, 27710, United States
Durham North Carolina, 27710, United States
Cancer Centers of the Carolinas Dept. of CC of the Carolinas
Greenville South Carolina, 29605, United States
Greenville South Carolina, 29605, United States
Cancer Care Centers of South Texas / HOAST CCC of So. TX- San Antonio(2)
San Antonio Texas, 78229, United States
San Antonio Texas, 78229, United States
Virginia Cancer Specialists, PC Dept.ofFairfax SC
Fairfax Virginia, 22031, United States
Fairfax Virginia, 22031, United States
Medical Oncology Associates, PS
Spokane Washington, 99208, United States
Spokane Washington, 99208, United States
Wenatchee Valley Medical Center Wenatchee Valley
Wenatchee Washington, 98801, United States
Wenatchee Washington, 98801, United States
Novartis Investigative Site
Rio Negro Viedma, 8500, Argentina
Rio Negro Viedma, 8500, Argentina
Novartis Investigative Site
Buenos Aires , C1050, Argentina
Buenos Aires , C1050, Argentina
Novartis Investigative Site
Cordoba , X5006, Argentina
Cordoba , X5006, Argentina
Novartis Investigative Site
Tucuman , T4000, Argentina
Tucuman , T4000, Argentina
Novartis Investigative Site
Salzburg , 5020, Austria
Salzburg , 5020, Austria
Novartis Investigative Site
Wien , 1090, Austria
Wien , 1090, Austria
Novartis Investigative Site
Leuven , 3000, Belgium
Leuven , 3000, Belgium
Novartis Investigative Site
Wilrijk , 2610, Belgium
Wilrijk , 2610, Belgium
Novartis Investigative Site
Salvador BA, 40170, Brazil
Salvador BA, 40170, Brazil
Novartis Investigative Site
Londrina PR, 86015, Brazil
Londrina PR, 86015, Brazil
Novartis Investigative Site
Porto Alegre RS, 90610, Brazil
Porto Alegre RS, 90610, Brazil
Novartis Investigative Site
Sao Jose do Rio Preto SP, 15090, Brazil
Sao Jose do Rio Preto SP, 15090, Brazil
Novartis Investigative Site
São Paulo SP, 01317, Brazil
São Paulo SP, 01317, Brazil
Novartis Investigative Site
Besançon cedex , 25030, France
Besançon cedex , 25030, France
Novartis Investigative Site
Bordeaux , 33076, France
Bordeaux , 33076, France
Novartis Investigative Site
Lille Cedex , 59020, France
Lille Cedex , 59020, France
Novartis Investigative Site
Saint-Herblain Cédex , 44805, France
Saint-Herblain Cédex , 44805, France
Novartis Investigative Site
Thonon-les-Bains Cedex , 74203, France
Thonon-les-Bains Cedex , 74203, France
Novartis Investigative Site
Villejuif Cedex , 94805, France
Villejuif Cedex , 94805, France
Novartis Investigative Site
Budapest , 1134, Hungary
Budapest , 1134, Hungary
Novartis Investigative Site
Budapest , 1145, Hungary
Budapest , 1145, Hungary
Novartis Investigative Site
Budapest , H-108, Hungary
Budapest , H-108, Hungary
Novartis Investigative Site
Debrecen , 4032, Hungary
Debrecen , 4032, Hungary
Novartis Investigative Site
Gyor , H-902, Hungary
Gyor , H-902, Hungary
Novartis Investigative Site
Szeged , H-672, Hungary
Szeged , H-672, Hungary
Novartis Investigative Site
Szolnok , H-500, Hungary
Szolnok , H-500, Hungary
Novartis Investigative Site
Macerata MC, 62100, Italy
Macerata MC, 62100, Italy
Novartis Investigative Site
Parma PR, 43100, Italy
Parma PR, 43100, Italy
Novartis Investigative Site
Sondrio SO, 23100, Italy
Sondrio SO, 23100, Italy
Novartis Investigative Site
Maastricht , 6229 , Netherlands
Maastricht , 6229 , Netherlands
Novartis Investigative Site
Rotterdam , 3075 , Netherlands
Rotterdam , 3075 , Netherlands
Novartis Investigative Site
Surquillo Lima, 34, Peru
Surquillo Lima, 34, Peru
Novartis Investigative Site
Poznan , 60-56, Poland
Poznan , 60-56, Poland
Novartis Investigative Site
Rzeszow , 35-02, Poland
Rzeszow , 35-02, Poland
Novartis Investigative Site
Warszawa , 02-78, Poland
Warszawa , 02-78, Poland
Novartis Investigative Site
Warszawa , 03-29, Poland
Warszawa , 03-29, Poland
Novartis Investigative Site
Warszawa , 04-12, Poland
Warszawa , 04-12, Poland
Novartis Investigative Site
Ryazan Russia, 39001, Russian Federation
Ryazan Russia, 39001, Russian Federation
Novartis Investigative Site
St. Petersburg , 19775, Russian Federation
St. Petersburg , 19775, Russian Federation
Novartis Investigative Site
Cape Town , 7500, South Africa
Cape Town , 7500, South Africa
Novartis Investigative Site
Parktown , 2193, South Africa
Parktown , 2193, South Africa
Novartis Investigative Site
Port Elizabeth , 6045, South Africa
Port Elizabeth , 6045, South Africa
Novartis Investigative Site
Toledo Castilla la Mancha, 45071, Spain
Toledo Castilla la Mancha, 45071, Spain
Novartis Investigative Site
Barcelona Catalunya, 08035, Spain
Barcelona Catalunya, 08035, Spain
Novartis Investigative Site
Valencia Comunidad Valenciana, 46010, Spain
Valencia Comunidad Valenciana, 46010, Spain
Novartis Investigative Site
Madrid , 28007, Spain
Madrid , 28007, Spain
Novartis Investigative Site
Niaosong Township , 83301, Taiwan
Niaosong Township , 83301, Taiwan
Novartis Investigative Site
Taichung , 407, Taiwan
Taichung , 407, Taiwan
Novartis Investigative Site
Taipei , 10048, Taiwan
Taipei , 10048, Taiwan
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