A Study to Evaluate the Safety and Tolerability of BMS-986403 in Participants With Relapsed and/or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
The purpose of this study is to evaluate the safety and preliminary efficacy of BMS-986403 in participants with relapsed and/or refractory leukemia-cll/" >chronic lymphocytic leukemia (R/R CLL) or small lymphocytic lymphoma (SLL).
Participants with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) and high-risk features must have failed at least 2 lines of prior therapy and participants with CLL or SLL and standard risk features must have failed at least 3 lines of prior therapy Eastern Cooperative Oncology Group (ECOG) performance status of ≤ 1 Either currently has central vascular access or is a candidate to receive central vascular access or peripheral vascular access for leukapheresis procedure Has recovery to Grade ≤ 1 or baseline of any non-hematologic toxicities due to previous therapy, except alopecia (any Grade acceptable) and peripheral neuropathy (Grade ≤ 2 acceptable)
Exclusion Criteria:
Any condition, including active or uncontrolled infection, or the presence of laboratory abnormalities, that places the subject at unacceptable risk if they were to participate in the study Systemic fungal, bacterial, viral, or other infection that is not controlled Active autoimmune disease requiring immunosuppressive therapy Progressive deep vein thrombosis or pulmonary embolism requiring treatment, but not yet on a stable anticoagulation regimen
Other protocol-defined inclusion/exclusion criteria apply