Akt Inhibitor MK2206, Bendamustine Hydrochloride, and Rituximab in Treating Patients With Relapsed Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Inclusion Criteria:

Diagnosis of chronic lymphocytic leukemia (CLL) according to the National Cancer Institute (NCI) criteria or small lymphocytic lymphoma (SLL) according to the World Health Organization (WHO) criteria; this includes previous documentation of:

Biopsy-proven SLL or

Diagnosis of CLL according to NCI working group criteria as evidenced by all of the following:

Peripheral blood B-cell count of > 5 x 10^9/L consisting of small to moderate size lymphocytes

Immunophenotyping consistent with CLL defined as:

The predominant population of lymphocytes share both B-cell antigens (CD19, CD20 [typically dim expression], or CD23) as well as CD5 in the absence of other pan-T-cell markers (CD3,CD2, etc.)
Clonality as evidenced by kappa (Κ) or lambda (λ) light chain expression (typically dim immunoglobulin expression) or other genetic method (e.g., immunoglobulin heavy chain variable [IGHV] analysis)
NOTE: splenomegaly, hepatomegaly, or lymphadenopathy are not required for the diagnosis of CLL
Before diagnosing CLL or SLL, mantle cell lymphoma must be excluded by demonstrating a negative fluorescence in situ hybridization (FISH) analysis for t (11;14) (IgH/CCND1) on peripheral blood or tissue biopsy, or negative immunohistochemical stains for cyclin D1 on involved tissue biopsy
Demonstrated progression after one or two prior lines of CLL therapy; note: rituximab monotherapy does not count as a prior line of therapy

Progressive disease with any one of the following characteristics based on standard criteria for treatment as defined by the NCI-Working Group (WG) 1996

Symptomatic CLL characterized by any one of the following:

Weight loss >= 10% within the previous 6 months
Extreme fatigue attributed to CLL
Fevers > 100.5° Fahrenheit (F) for 2 weeks without evidence of infection
Drenching night sweats without evidence of infection
Evidence of progressive bone marrow failure with hemoglobin < 11 g/dL or platelet count < 100 x 10^9/L
Massive or rapidly progressive splenomegaly (> 6 cm below left costal margin)
Massive (> 10 cm) or rapidly progressive lymphadenopathy
Life expectancy >= 12 months
Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0, 1, or 2
Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) unless due to Gilbert's disease; if total bilirubin is > 1.5 x ULN, a direct bilirubin should be performed and must be < 1.5 mg/dL for Gilbert's to be diagnosed
Serum glutamic oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST]) =< 2.5 ULN
Serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) =< 2.5 times ULN
Creatinine =< 1.5 times ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels > 1.5 x ULN
A non-transfused platelet count >= 30 x 10^9/L
Neutrophil count (absolute neutrophil count [ANC]) >= 1 x 10^9/L
Hemoglobin (Hgb) >= 8 g/dL
Note: cytopenias due to bone marrow failure are common in patients with relapsed CLL requiring treatment; accordingly, normal bone marrow function is NOT required for participation
Negative pregnancy test done =< 7 days prior to registration, for women of childbearing potential only
Ability to complete patient diaries and questionnaire(s) by themselves or with assistance
Provide informed written consent
Willing to return to North Central Cancer Treatment Group (NCCTG) enrolling institution for follow-up
Willing to provide blood samples for correlative research purposes
Willing to provide bone marrow aspirate (body fluid) for correlative research purposes
MAYO ROCHESTER ONLY: willing to provide bone marrow core biopsy tissue for correlative research purposes
Willing to provide bone marrow biopsy for central pathology review (all patients)
Able to swallow whole tablets; NOTE: nasogastric or gastrostomy (G) tube administration is not allowed; tablets must not be crushed or chewed

Exclusion Criteria:

Prior treatment with bendamustine
Prior treatment with any experimental Akt inhibitors
More than 2 previous purine nucleoside based-therapy (i.e. fludarabine, pentostatin, or cladribine)
More than 2 previous alkylating agent based-therapy (i.e. cyclophosphamide, chlorambucil)
More than 3 total prior lines of therapy for CLL
Primary refractory disease as defined by progression while receiving or within 6 months of completion of a chemoimmunotherapy regimen such as fludarabine, cyclophosphamide and rituximab (FCR) or pentostatin, cyclophosphamide and rituximab (PCR)
PHASE II ONLY: FISH abnormality of 17P deletions; (note: patients with 17P deletions will be included in Phase I but will be excluded in Phase II unless enough activity is found in the Phase I)
Pregnant women
Nursing women
Men or women of childbearing potential who are unwilling to employ adequate contraception

Co-morbid systemic illnesses or other severe concurrent disease which, in the judgment of the investigator, would make the patient inappropriate for entry into this study or interfere significantly with the proper assessment of safety and toxicity of the prescribed regimens; including but not limited to the following:

New York Heart Association class III or IV heart disease
Recent myocardial infarction (< 1 month)
Uncontrolled infection
Known infection with the human immunodeficiency virus (HIV/acquired immune deficiency syndrome [AIDS]) and/or patients taking highly active antiretroviral therapy (HAART) as further severe immunosuppression with this regimen may occur
Infection with known chronic, active hepatitis C
Positive serology for hepatitis B (HB) defined as a positive test for hepatitis B surface antigen (HBsAg); in addition, if negative for HBsAg but hepatitis B core antibody (HBcAb) positive (regardless of hepatitis B surface antibody [HBsAb] status), a HB deoxyribonucleic acid (DNA) test will be performed and if positive the subject will be excluded
Uncontrolled diabetes defined as hemoglobin A1c (HbA1c) >= 8 or fasting blood glucose >= 140 mg/dL

Any of the following:

History of significant ventricular arrhythmia in the last 5 years including: ventricular tachycardia or ventricular fibrillation
Corrected QT (QTc) prolongation on baseline electrocardiogram (ECG) (defined as a QTc interval > 450 msec for males and QTc interval > 470 msec for females)
Currently using a medication known to cause prolonged QTc which cannot be discontinued; note: other medications with possible risk of prolonged QTc are allowed but should be used with caution; patients using these medications should be monitored accordingly
Ventricular arrhythmia on baseline ECG (ventricular tachycardia or ventricular fibrillation >= 3 beats in a row)
Second or third degree heart block
Receiving any other investigational agent concurrently which would be considered as a treatment for the primary neoplasm
Other active primary malignancy requiring treatment or which limits survival to < 24 months
Any major surgery =< 28 days prior to registration
Any radiation therapy =< 4 weeks prior to registration
Current use of corticosteroids; EXCEPTION: low doses of steroids (< 10 mg of prednisone or equivalent dose of other steroid) used for treatment of non-hematologic medical conditions; NOTE: previous use of corticosteroids is allowed
Active hemolytic anemia requiring immunosuppressive therapy or other pharmacologic treatment; NOTE: patients who have a positive Coombs test but no evidence of hemolysis are NOT excluded from participation

Receiving any medications or substances that are strong or moderate inhibitors of cytochrome P450 3A4 (CYP450 3A4); use of the following strong or moderate inhibitors are prohibited =< 7 days prior to registration:

Strong inhibitors of CYP3A4

Indinavir
Nelfinavir
Ritonavir
Clarithromycin
Itraconazole
Ketoconazole
Nefazodone
Saquinavir
Telithromycin

Moderate inhibitors of CYP3A4

Aprepitant
Erythromycin
Fluconazole
Grapefruit juice
Verapamil
Diltiazem

Receiving any medications or substances that are inducers of CYP450 3A4; use of the following inducers is prohibited =< 12 days prior to registration

Inducers of CYP3A4

Efavirenz
Nevirapine
Carbamazepine
Modafinil
Phenobarbital
Phenytoin
Pioglitazone
Rifabutin
Rifampin
St. John's wort