Chronic Lymphocytic Leukemia Clinical Trial
Alemtuzumab Plus Peripheral Stem Cell Transplantation in Treating Patients With Chronic Lymphocytic Leukemia
RATIONALE: Monoclonal antibodies such as alemtuzumab can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy or radiation therapy. Combining monoclonal antibody therapy, chemotherapy, radiation therapy, and peripheral stem cell transplantation may kill more tumor cells.
PURPOSE: Phase II trial to study the effectiveness of alemtuzumab plus peripheral stem cell transplantation in treating patients who have leukemia-cll/" >chronic lymphocytic leukemia.
Determine the ability of in vivo purging with alemtuzumab (monoclonal antibody CD52; Campath-1H) to produce a stem cell graft without detectable leukemia cells in patients with chronic lymphocytic leukemia.
Determine the ability to successfully mobilize stem cells after in vivo purging with monoclonal antibody CD52 in these patients.
Determine the toxicity of this treatment regimen in these patients.
Determine the response to this treatment regimen in these patients at 6 months after peripheral blood stem cell transplantation.
OUTLINE: This is a multicenter study.
Patients receive induction therapy comprising alemtuzumab (monoclonal antibody CD52; Campath-1H) IV over 2 hours three times a week for 4 weeks.
Beginning no more than 2 weeks after induction therapy, patients receive mobilization chemotherapy comprising cyclophosphamide IV over 1-2 hours on day 1 and filgrastim (G-CSF) subcutaneously (SC) starting on day 2 and continuing until the last day of apheresis. Patients undergo peripheral blood stem cell apheresis on days 10-14.
Beginning 2-4 weeks after apheresis, patients receive a preparative regimen comprising cyclophosphamide IV over 2 hours on days -5 and -4 and fractionated total body irradiation twice a day over 6-10 hours on days -3 to -1. Patients undergo peripheral blood stem cell transplantation on day 0. Patients receive G-CSF SC beginning on day 1 and continuing until blood counts recover.
Patients are followed at 60 days, 1 year, and then annually thereafter until disease progression.
PROJECTED ACCRUAL: A total of 30 patients will be accrued for this study.
Diagnosis of chronic lymphocytic leukemia (CLL) that meets the following criteria at any point prior to study entry:
Peripheral blood absolute blood count greater than 5,000/mm^3
Lymphocytosis must comprise small to moderate size lymphocytes with no more than 55% prolymphocytes, atypical lymphocytes, or lymphoblasts morphologically
Phenotypically characterized B-cell CLL
Splenomegaly, hepatomegaly, or lymphadenopathy not required for CLL diagnosis
Must have bone marrow biopsy within 4 weeks of study entry showing cellularity of at least 25% of intratrabecular space and lymphocytes accounting for no more than 30% of nucleated cells
18 to 65
See Disease Characteristics
Absolute neutrophil count at least 1,000/mm^3
Hemoglobin at least 11 g/dL
Platelet count at least 100,000/mm^3
Bilirubin no greater than 2 mg/dL (unless secondary to tumor)
AST or ALT less than 3 times upper limit of normal
Hepatitis B surface antigen negative
Hepatitis C RNA negative
Creatinine no greater than 2.0 mg/dL
Left ventricular ejection fraction at least 45% by echocardiogram or MUGA
DLCO, FEV_1, and FVC greater than 50% of predicted
No active infection requiring oral or IV antibiotics
No other prior malignancy within the past two years except basal cell skin cancer or carcinoma in situ of the cervix
Not pregnant or nursing
Negative pregnancy test
Fertile patients must use effective contraception
PRIOR CONCURRENT THERAPY:
Prior monoclonal antibody CD52 allowed if at least partial remission was achieved with last treatment
No more than 2 prior chemotherapy regimens
At least 3 weeks since prior chemotherapy
No more than 8 courses of prior fludarabine therapy
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There are 13 Locations for this study
Chicago Illinois, 60611, United States
Chicago Illinois, 60611, United States
Baltimore Maryland, 21231, United States
Boston Massachusetts, 02111, United States
Boston Massachusetts, 02215, United States
Saint Louis Park Minnesota, 55416, United States
Hackensack New Jersey, 07601, United States
Danville Pennsylvania, 17822, United States
Hershey Pennsylvania, 17033, United States
Philadelphia Pennsylvania, 19104, United States
Philadelphia Pennsylvania, 19111, United States
Pittsburgh Pennsylvania, 15236, United States
Madison Wisconsin, 53792, United States
Marshfield Wisconsin, 54449, United States
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