Chronic Lymphocytic Leukemia Clinical Trial
Characterization of Proliferating Compartment in B-Cell Patients and in Healthy Aging Subjects
Summary
By ingesting a non-radioactive and non-toxic compound "heavy water" for 6 weeks, the DNA of newly developed cells in the body of subjects with B-cell leukemia-cll/" >chronic lymphocytic leukemia can be labeled and followed by performing routine blood draws at specified time intervals. By using mass spectrometric analysis we can measure how quickly new B-CLL cells are generated in the bone marrow and how quickly they leave the blood, a measure of cell turnover. This will help us to better understand the unique characteristics of this disease process.
Full Description
By ingesting a non-radioactive and non-toxic compound "heavy water" for 6 weeks, the DNA of newly developed cells in the body of subjects with B-cell chronic lymphocytic leukemia (B-CLL) can be labeled and followed by performing routine blood draws at specified time intervals. By using mass spectrometric analysis we can measure how quickly new B-CLL cells are generated in the bone marrow and how quickly they leave the blood, a measure of cell turnover. This will help us to better understand the unique characteristics of this disease process.
Eligibility Criteria
Inclusion Criteria:
18 years of age,
Patients must be willing to contribute the required amount of blood without compromising their well being,
Participants must be willing to be contacted in the future.
Exclusion Criteria:
Pregnancy,
Patients who are known to be anemic, with a hemoglobin < 8,
Patients who are known to be infected with HIV.
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There is 1 Location for this study
Manhasset New York, 11030, United States
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