Cyproheptadine and Megestrol in Preventing Weight Loss in Children With Cachexia Caused By Cancer or Cancer Treatment

INCLUSION CRITERIA:

Any cachectic patient with weight loss presumed secondary to cancer or cancer related therapy is eligible. Cachexia is defined as having one or more of the following:
documented history of weight loss > 5%
drop in growth rate two or more percentile ranks on standard growth charts,
weight for height less than the tenth percentile.
Patients with newly diagnosed or relapsed cancer of any type, including brain tumors.
Patients who are receiving active or palliative therapy are eligible.
If patients have completed treatment for cancer (surgery, chemotherapy, radiotherapy) within 8 weeks of study registration, they are also eligible.
Patients must be ≥ 2 years and < 21 years of age at the time of admission to this study.
Patients must have a predicted life expectancy of at least eight weeks.

EXCLUSION CRITERIA:

Patients who are currently taking or who have taken Periactin and/or Megace during the past three weeks are not eligible.
Patients receiving corticosteroid or monoamine oxidase (MAO) inhibitor therapy. (Intermittent steroid use is permitted IF you anticipate it will not be administered for more than 7 days in a 4 week period. Calculate anticipated intermittent steroid use in 4-week intervals through the 8-week period during which study agent may be administered (4 weeks for Periactin and potentially 4 weeks for Megace.
Patients who have received parenteral nutrition or tube feedings within 1 week of starting this protocol or patients who are expected to require parenteral nutrition or tube feedings during the 4-week course of this study.
Patients taking dronabinol (Marinol) or other appetite-stimulating medications during the past three weeks or patients expected to be prescribed appetite-stimulating medications during the 4-week course of this study.
Patients with hormone sensitive tumors specifically meningiomas, breast cancer, ovarian cancer, and endometrial carcinoma.31, 32
Children with neurofibromatosis, type I or II, are at risk for the development of meningiomas and are thus excluded from this study.32
Children with glaucoma, chronic persistent asthma, or gastrointestinal (GI) or genitourinary (GU) obstruction.
Patients with recurrent and/or persistent hypertension, defined as blood pressure values >20% above normal.
Patients with thromboembolic disease, congestive heart failure, or peripheral edema.
Patients who are pregnant.