Donor Stem Cell Transplant in Treating Patients With High-Risk Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Patient Eligibility:

Diagnosis of B-cell chronic lymphocytic leukemia or B-cell small lymphocytic lymphoma.

Diagnosis should be according to International Workshop on Chronic Lymphocytic Leukemia (IWCLL) 2008 Criteria

Early Disease Cohort - Patients in the early disease cohort must include one or more of the following:

FISH showing deletion 17p in ≥ 20% of cells (either at diagnosis or any time prior to study entry) either alone or in combination with other cytogenetic abnormalities
FISH showing del 11q in ≥ 20% of cells (either at diagnosis or any time prior to study entry) either alone or in combination with other cytogenetic abnormalities, unless the patient has achieved a complete remission by IWCLL 2008 which includes CT scan, bone marrow morphology and flow cytometry
Failure to achieve a partial response with initial chemotherapy, but with lack of progression. These patients may receive a second therapy to improve their response prior to transplant.
Patients who, at the time of first progression, have a 17p deletion by FISH in ≥ 20% of cells, either alone or in combination with other cytogenetic abnormalities.

The duration of the first progression is not specified.

In addition, patients in the early disease cohort must have all of the following:

Received at least 2 cycles of induction therapy. It is expected that most patients will receive at least 4 months of therapy prior to enrollment, but this is not required. Suggested regimens include but are not limited to the following: fludarabine plus rituximab, fludarabine, cyclophosphamide plus rituximab, pentostatin, cyclophosphamide plus rituximab, bendumustine plus rituximab, or alemtuzumab alone or in combination with other agents. Patients may receive no more than 2 different regimens prior to proceeding to transplantation.
Nodes ≤ 5 cm

Advanced Disease Cohort - Patients in the advanced disease cohort must include one or more of the following:

FISH showing deletion 17p in ≥ 20% of cells (regardless of interval from initial therapy) either alone or in combination with other cytogenetic abnormalities
First progression < 24 months after completing therapy. This includes progression on initial therapy.
Second or subsequent progression

In addition, patients in the advanced disease cohort must have all of the following:

Stable disease or better by the Revised IWCLL 2008 NCI Criteria to their most recent chemotherapy
Nodes ≤ 5 cm
Eastern Cooperative Oncology Group (ECOG) Performance Status 0-2
Age Requirement - Patients must be between ≥ 18 and < 70 years of age
Cytotoxic Chemotherapy or Alemtuzamab - There must be at least 4 weeks after day 1 of the last cycle of cytotoxic chemotherapy, or alemtuzamab.

Human Immunodeficiency Virus (HIV) Status - Patients must have no HIV infection.

Allogeneic transplantation in the HIV patient population is not well-defined and there are likely to be requirements for concomitant anti-HIV therapy and anti-GVHD therapy that would create potentially dangerous pharmacokinetic interactions among the different agents that could constrain therapeutic options for controlling both HIV and GVHD.

Hepatitis B and C - Patients must have no Hepatitis B sAg, anti-HBc or HCV.
Diffusion capacity of carbon monoxide DLCO must be ≥ 40% predicted
Left ventricular ejection fraction (LVEF) by Echocardiogram (ECHO) or Multiple gated acquisition (MUGA) must be ≥ 30%
Diabetes or Serious Infection - Patients must have no uncontrolled diabetes mellitus or active uncontrolled serious infections

Pregnancy and Nursing Status - Patients must be non-pregnant and non-nursing. Treatment under this protocol would expose a fetus to significant risks. Women of childbearing potential should have a negative pregnancy test prior to study entry.

Women and men of reproductive potential should agree to use an appropriate method of birth control throughout their participation in this study due to the teratogenic potential of the therapy utilized in this trial. Appropriate methods of birth control include oral contraceptives, implantable hormonal contraceptives (Norplant®), or double barrier method (diaphragm plus condom).

Richter's Transformation - Patients must have no history of Richter's transformation.

Initial Required Laboratory Values:

Serum Creatinine < 2 mg/dL
Calculated Creatinine Clearance ≥ 40 mL/min
AST < 3 x ULN
Total Bilirubin < 2 mg/dL (except for Gilbert's syndrome)

Donor Eligibility:

Donors may be either a 6/6 HLA-matched related donor by low-resolution typing at HLA A, B, DR.
Donors may be an 8/8 HLA-matched unrelated donor at HLA A, B, C, DR. Unrelated donors will be analyzed by molecular typing at both HLA Class I and Class II (A, B, C, DR loci).
Syngeneic donors are not eligible
Donors must be healthy and must be an acceptable donor as per institutional standards for stem cell donation.
There will be no donor age restriction.