The purpose of this study is to evaluate the safety and effectiveness of the combination of bendamustine and ofatumumab in subjects with relapsed/refractory leukemia-cll/" >chronic lymphocytic leukemia and small cell lymphoma. All subjects enrolled on this study will receive both drugs by intravenous (IV) infusion.
Pathologically confirmed CLL or SLL requiring therapy Age 18 years of age or older ECOG performance status 0, 1, or 2 Normal organ and bone marrow function Resolution of toxic effects from prior therapies Ability to adhere to the study schedule and give written informed consent
Exclusion Criteria:
Any serious medical, psychiatric illness or laboratory abnormality Chemotherapy or radiotherapy within 4 weeks of entering the study Currently receiving other treatment for CLL/SLL or other malignancies Active other malignancies History of allergic reactions to bendamustine or ofatumumab Ongoing corticosteroid use Pregnant or lactating HIV positive Active hepatitis B Allogeneic transplant within 6 months of entering study or graft-versus-host disease.
